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Biomedical subjects

M B Jacobs

Publications and source records attributed to M B Jacobs.

At least 37 records · Page 2Linked to original sources
PubMed1991

Treating the progressive stages of Parkinson's disease.

Parkinson's disease affects thousands of Americans, men and women equally and apparently with little regard to race. Its diagnosis depends largely on repeated clinical observations of representative signs, such as resting tremor, rigidity, bradykinesia, and gait disturbances. Patients progress through stages: Early disease involves only one limb or side and confers minimal disability, but advanced disease restricts patients to full care. Treatment is chosen on the basis of disease stage and patient response. Combination carbidopa-levodopa (Sinemet) is appropriate for any significant degree of disability, and other antiparkinsonian drugs and anticholinergic agents may be used as adjuncts. Electroconvulsive therapy, use of selegiline hydrochloride (Eldepryl), and surgery are still undergoing investigation but may hold promise.

Amantadine↗
PubMed1990

Iatrogenic disease and the primary care physician.

Primary care physicians need to be aware of iatrogenic disease and its causes. Adverse drug reactions, including drug-drug interactions, and certain diagnostic procedures may lead to iatrogenic complications. Hospitalized patients, especially the elderly, face increased risks of such complications. Physicians who are aware of common adverse reactions to drugs, drug combinations, and medical procedures may be able to help patients avoid unnecessary distress and morbidity.

Aged↗
PubMed1986

Local subcutaneous atrophy after corticosteroid injection.

Subcutaneous atrophy developed in a 36-year-old woman at the site of a triamcinolone acetonide (Kenalog) injection for subdeltoid bursitis. Occurrence of local atrophy after corticosteroid injection is relatively frequent yet unappreciated. It is more common in young women and girls who are given preparations with a lesser degree of water solubility. Although the condition is often reversible, instances of long-term disfigurement are well documented. This complication of a useful treatment method can be avoided by following a set of precautions for local injection of corticosteroids.

Adrenal Cortex Hormones↗
PubMed1985

Medical complications of bulimia: a prospective evaluation.

Recent increase in the identification and treatment of bulimia, an eating disorder characterised by excessive eating and often accompanied by some form of purging behaviour, has led to an interest in its proper medical evaluation. Although scattered reports describe a multitude of associated medical complications, their true incidence is not known. We describe our experience with 39 consecutive bulimic patients who underwent thorough medical evaluation. Serious disease was rarely encountered although a significant association was found between low body weight and hypokalaemia. Elevated serum amylase values were also noted in 15 of 24 patients (62 per cent). The potential utility of the latter in treating bulimic patients is discussed. A practical approach to the management of these patients is outlined.

Adolescent↗
PubMed1985

Eosinophilic fasciitis, reactive hepatitis, and splenomegaly.

Eosinophilic fasciitis (EF) is an acute, idiopathic inflammatory disorder often manifested by tender swelling of the extremities after extreme physical exertion. It is usually without visceral complications. I treated a 25-year-old man with EF who had reactive hepatitis and splenomegaly. To my knowledge, the former has never been reported and the latter only once.

Adult↗
PubMed1984

Thrombotic and infectious complications of Hickman-Broviac catheters.

Hickman-Broviac catheters are often used when long-term venous access is required. Although generally safe, catheter-related thrombosis and infection are two of the most frequent and clinically important complications associated with their use. A 47-year-old woman with breast cancer had a Hickman catheter placed for chemotherapy; subsequently, the superior vena caval syndrome developed due to a large thrombus surrounding the catheter tip. A very low dose of streptokinase successfully lysed this clot within 12 hours. A 60-year-old woman with acute myelogenous leukemia had a Hickman catheter placed to facilitate induction and maintenance chemotherapy. Two episodes of catheter-related Staphylococcus epidermidis sepsis later developed, the first of which cleared without removal of the cannula.

Breast Neoplasms↗
PubMed1984

Hepatic infarction related to oral contraceptive use.

The first case of oral contraceptive (OC)-related common hepatic artery thrombosis with subsequent hepatic infarction is reported. Hepatic complications of OC use are enumerated and the clinical manifestation of hepatic infarction is described. Propranolol hydrochloride, because of its effect on liver blood flow, may have contributed to this disease process.

Adult↗
PubMed1980

Antagonist EMG temporal patterns during rapid voluntary movement.

This study of 10 normal college-aged women was designed to clarify possible antagonist control mechanisms during the silent period of the agonist in rapid elbow extension tasks. Antagonist electromyographic temporal patterns were observed after agonist silence under various conditions to determine if antagonist activity in the rapid movement was controlled supraspinally (preprogrammed), spinally (reflexively), or by a combination of the two mechanisms. The subjects followed a velocity-controlled dot displayed on an oscilloscope. The antagonist latencies remained constant during intentionally and unintentionally terminated movements, but were altered by load conditions. This was seen as an automatic deceleration response, elucidating differences between antagonist control during ballistic and rapid movements.

Action Potentials↗