Search PubMed⌕ Search

Biomedical subjects

M B Cooper

Publications and source records attributed to M B Cooper.

47 records · Page 3Linked to original sources
PubMed1977

The effect of synchronization on the interpretation of flashing lamp displays.

The question of whether all the lamps on a display indicating the same state should flash in phase with each other or independently is of interest to display designers. A randomized groups experiment was carried out to answer this question. It was found that a synchronized display was interpreted more quickly and with fewer errors than a display with independently flashing lamps.

Journal Article↗
PubMed1976

The effect of keypad angle of a table keyphone on keying performance.

Two keypad angle experiments, one numeral legibility experiment and one button-tapping rate experiment are described. The effects of keypad angle on keyphone positioning, keying time, keying errors and on a keying performance measure are discussed. A geometrical method for estimating optimum keypad angle is introduced. It is concluded that the optimum angle for a keypad depends on its height above the desk surface. The geometrical method can be used to estimate the best anglein the absence of experimental evidence. For the experimental keyphone (keypad height about 90 mm) the best keypad angle was found to be about 25 degrees to the horizontal, but the effect of a 10 degrees deviation either way from this angle was quite small.

Journal Article↗
PubMed1975

Gastroduodenal Crohn's disease presenting as biliary colic.

A 31-year old physician, with a 15-year history of regional enteritis, presented with a gallstone and biliary colic, who on further work-up proved to have Crohn's disease of the stomach and duodenum. Roentgenographic, endoscopic and biopsy material were all consistent with Crohn's disease of the stomach and duodenum. Response to steroid treatment indicated that the symptoms were secondary to Crohn's disease and, as such, this is the first report of this rare problem. Further, to our knowledge this represents only the ninth endoscopy and only the second biopsy via endoscopy to demonstrate a noncaseating granuloma from the stomach in this disease.

Adult↗
PubMedDate not supplied

The effect of age on the activity of enzymes of peroxide metabolism in rat brain.

The activity of some enzymes associated with peroxide metabolism and cytochrome oxidase activity was measured in cortex, striatum, hypothalamus, and hippocampus from brains of rats aged either 4, 15, or 27 months. Cytochrome oxidase activity was greatest in the cortex, but no significant age-related changes in the activity of cytochrome oxidase, superoxide dismutase, or glutathione peroxidase were found in any of the brain areas. In contrast, glutathione reductase activity increased as a function of age in all regions. In general, the activity of catalase fell on maturation of the animal to adulthood and then showed a trend to increase with age.

Aging↗
PubMedDate not supplied

Glycosylation and cross-linkage of cardiac myosin in diabetic subjects: a post-mortem study.

We have investigated the possibility that post-translational modification of myosin by protein glycosylation and cross-linking occurs in cardiac myosin. Left ventricular muscle was obtained at post-mortem from 6 diabetic and 7 non-diabetic subjects. Myosin was extracted from muscle and purified using Sephadex chromatography followed by protein concentration. Glycosylation was estimated using boronate affinity chromatography with the myosin dissolved in a pyrophosphate buffer, the glycosylated myosin being displaced with sorbitol. Cross-linkage was assessed by fluorescence at 440 nm upon excitation at 370 nm. Diabetic subjects had significantly higher levels (p less than 0.02) of glycosylated myosin (median 6.0% (range 3.8-6.6%] than non-diabetic subjects (median 2.4% (range 0.3-4.2%] but there was no difference in the degree of cross-linkage as assessed by fluorescence (diabetic median 9.8 (range 6.5-17.0) arbitrary units; non-diabetic median 9.7 (range 6.0-11.4) arbitrary units). Glycosylation of left ventricular myosin may be of relevance to the excess risk of congestive cardiac failure in diabetic patients.

Aged↗