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Biomedical subjects

M Asmussen

Publications and source records attributed to M Asmussen.

At least 19 recordsLinked to original sources
PubMed2000

Effects of serotonin(1/2) receptor agonists on dark-phase food and water intake in rats.

The effects of serotonin (5-hydroxytryptamine, 5-HT)(1/2) receptor agonists for 5-HT(1) and 5-HT(2) receptors on dark-phase ingestive behavior were evaluated in 12-h food-deprived, female Wistar rats. The amount of food and water consumed after 1, 2, 6 and 12 h was measured. The following agonists were tested: ipsapirone [preferred 5-HT receptor(s) and dose range in mg/kg, IP: 5-HT(1A) and 3-30, respectively], CP-94,253 (5-HT(1B); 0.3-3), TFMPP (5-HT(1B/2C); 0. 3-10), m-CPP (5-HT(2C/1B); 0.3-10), ORG 37684 (5-HT(2C); 0.3-10), BW 723C86 (5-HT(2B); 3-30) and DOI (5-HT(2A/2C); 0.3-3). Ipsapirone induced hyperphagia during the first hour of food access and hypophagia during the last interval. All other compounds induced dose- and time-dependent hypophagia. m-CPP and TFMPP induced the most marked reduction of food intake and were the only drugs inducing rebound hyperphagia. Except for m-CPP and TFMPP, effects on food intake could generally be dissociated from effects on water intake. The receptor profile of the compounds tested suggests that stimulation of 5-HT(1B), 5-HT(2C), 5-HT(2A) or 5-HT(2B) receptors results in hypophagia. As the less selective agonists were the more potent anorexics, it is suggested that simultaneous activation of these receptors results in synergistic effects on ingestive behavior. Additional antagonism studies are required to ascertain the proposed role of particular 5-HT receptor subtypes in the hypophagic effects of the tested compounds.

Amphetamines↗
PubMed1988

Primary adenocarcinoma localized to the fallopian tubes: report on 33 cases.

Thirty-three cases of primary adenocarcinoma localized to the fallopian tubes were analyzed according to prognostic factors such as depth of infiltration, tumor differentiation, and lymph vessel invasion. Fifteen patients (45, 5%) died of recurrence within 5 years. Only for positive vessel invasion was the survival significance worse. Combination chemotherapy seems promising compared to radiotherapy in these early stages.

Adenocarcinoma↗
PubMed1988

Reimplantation of a benign ovarian tumor.

An unusual case of a benign ovarian tumor, which had been torn off its primary usual anatomical site and transplanted to a new intra-abdominal location with new blood supply from the omentum, is described.

Aged↗
PubMed1987

[Gallium scintigraphy of gynecologic neoplasms].

67Gallium whole body scintigraphy was applied in 16 patients with gynecological malignomas and 2 patients with suspicion on a recurrent tumour as a supplement to usual diagnostic procedure. Aim of this study was the detection of metastases earlier than with the usual methods. Scintigraphy results have been interpreted average of 5 years after examination. Additional clinical informations were necessary in 6 cases. 3 out of these 6 cases have been shown in detail.

Female↗
PubMed1987

[Immediate disorders of urination following radical hysterectomy in cervix cancer].

Function of the lower urinary tract has been estimated in 23 patients with cervical carcinoma stage I-II before and after radical hysterectomy using simultaneous urethrocystometry with microtip transducer technique. The hypogastic nervous plexus could be preserved in 18 patients, but in 5 patients because of the increased radicality of the operation it was resected. Two weeks after operation no detrusor activity could be measured in all 5 patients with and in 13 out of 18 patients without plexus resection. In these patients a hypoactivity of the lower urinary tract with typical overflow incontinence and large residual urinary volume has been detected. Signs of a detrusor hyperactivity could be found in none of the 23 patients. The hyperactive bladder after radical hysterectomies often described is supposed to be a artefact caused by measuring technique. Because function of lower urinary tract has been examined in former studies with conventional cystometry with fast filling of bladder. The urethral function has been neglected more or less. The results obtained by simultaneous urethrocystometry support the assumption, that the primary reasons of the temporary and partly continuous changes of bladder and urethral function are pelvic hematomas, lymphatic vessel dysfunction, edema of bladder, direct surgical lesions of pelvic tissue and fibroses. Partial denervation may be joined partly. The most likely cause of cystometric changes is reduced distensibility of bladder and not hypertonic detrusor function.

Adult↗
PubMed1985

Anatomical and functional changes in the lower urinary tract after radical hysterectomy with lymph node dissection as studied by dynamic urethrocystography and simultaneous urethrocystometry.

Seventeen urologically healthy women undergoing standardized radical hysterectomy with lymph node dissection for stage I carcinoma of the cervix were evaluated urodynamically before, immediately after, and 1 year after surgery, by dynamic videourethrocystography and simultaneous urethrocystometry. The surgical technique had been developed in order to preserve as much of the nerve and blood supply to the bladder and urethra as possible. Major dysfunction was found in the early postoperative state, but the lower urinary tract almost always regained its preoperative functional status in the course of approximately 1 year. There were no long-lasting functional changes which interfered with daily life, although small static and dynamic changes were observed. The changes occurred chiefly above the urogenital diaphragm. The results of the two urodynamic examinations, each giving different information, corresponded well. Used together they gave a more complete picture than used separately. Dynamic videourethrocystography offered information about the function of the bladder and urethra which could not be obtained by urethrocystometry alone.

Adult↗
PubMed1985

Acute urinary retention in first trimester of pregnancy.

A 34-year old pregnant women with retroverted uterus and suffering from acute attacks of urinary retention in the first trimester of pregnancy is described. The attacks of retention were caused by the enlarged retroverted uterus associated with a 1x1 cm, well differentiated papilliferous carcinoma in the right side of the trigone. The urinary symptom disappeared after resection of the tumor.

Acute Disease↗
PubMed1983

Dynamic urethrocystography in women.

A technique for video urethrocystography in women is described and evaluated from the results of examinations on 76 subjects. The patients were examined seated in the lateral position and investigations were carried out at rest, and during straining and coughing, micturition and holding-back maneuvers. Special attention was paid to the overall morphology and the position of the bladder base, the bladder neck and the urethra. Apart from the contour of the symphysis, which in some patients was difficult to identify, the various structures were easily displayed. Also the dynamics of the function of the bladder base, the bladder neck and the urethra were visualized. Almost all patients were able to carry out all parts of the examination including micturition without difficulty. TLD dosimeters in the vagina and uterus showed a low radiation dose to the ovaries.

Adult↗
PubMed1982

Location of maximum intraurethral pressure related to urogenital diaphragm in the female subject as studied by simultaneous urethrocystometry and voiding urethrocystography.

The urethral pressure profiles were recorded by microtransducers in 25 continent female subjects. From the recordings, the urethral length and the site of maximum intraurethral pressure were determined with a high degree of precision. The urethral length and the distance from the external urethral meatus to the urogenital diaphragm were also assessed on 100 mm roentgenograms taken in the lateral projection. When the results from both recording techniques were compared, the urogenital diaphragm was found to be located, on average, 5.2 mm more distal in the urethra than the site of the maximum urethral pressure. Thus, the conclusion to be drawn is that the high-pressure zone of the urethra in continent women is located proximal to the urogenital diaphragm.

Adult↗
PubMed1982

Lymphography following complete dissection of iliac lymph nodes.

Twenty-five patients with carcinoma of the uterine cervix stage I were treated by radical hysterectomy and complete iliac lymph node dissection. None of the patients had postoperative lymphedema. Postoperative lymphography was performed in 6 of the patients. The flow time of contrast medium from the foot to the inguinal region was compared with that of a control group. Five different postoperative flow patterns were observed. No delay of the flow was found.

Collateral Circulation↗
PubMed1982

Effects of radical hysterectomy with lymph nodes dissection on the lower urinary tract.

In 18 patients with carcinoma of the urine cervix stage I-II lower urinary tract function was evaluated by urethral pressure profile measurements and flow measurements before and after radical hysterectomy. A specially designed surgical procedure was used which avoided transection of the nerve supply to the lower urinary tract. The most conspicuous finding was a significant decrease detrusor activity 14 days after the operation. Urethral function was almost unaffected. One year postoperatively all patients had an almost normal function of the lower urinary tract with no residuals. It is concluded that the decreased detrusor function observed 14 days after the operation was due to a direct trauma of the bladder and the bladderwall bringing about a myogenic injury which temporarily paralyzed the bladder. If special attention is paid during surgery to save the nerve supply to the bladder and the urethra, longlasting postoperative dysfunction of the lower urinary tract can be avoided after radical hysterectomy for carcinoma of the uterine cervix without compromising radicality.

Adult↗
PubMed1980

Factors maintaining the intraurethral pressure in women.

To determine the components of the intraurethral pressure at rest, five continent women were studied with simultaneous urethrocystometry, including urethral pressure profile measurements, before, during and after curarization, as well as after clamping of the arterial blood supply to the urethra. The results showed that the striated muscle component in the urethra and pelvic floor is responsible for one-third of the total intraurethral pressure. Another one-third is exerted by the urethral vascular bed. The remaining one-third is most probably attributable to the smooth musculature and connective tissues in the urethra and the periurethral tissues.

Adult↗
PubMed1977

A new technique for simultaneous urethrocystometry including measurements of the urethral pressure profile.

A new standardized technique for continuous recording of the urethral pressure profile simultaneously with intravesical pressure has been developed. The pressure are recorded using two microtransducers enclosed in a thin Dacron catheter. The catheter is moved at a constant speed through the urethra with the aid of a specially designed withdrawal instrument. Using electronic subtraction the closure pressure can easily be measured simultaneously with the intravesical and intraurethral pressure. About 900 investigations have been performed with this technique. It has been testified that very detailed information about normal micturition as well as stress and urgency incontinence can be obtained. The functional as well as the absolute length of the urethra can be estimated within half a millimeter.

Female↗