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Biomedical subjects

M Aschermann

Publications and source records attributed to M Aschermann.

120 records · Page 7Linked to original sources
PubMed1977

Changes in the P-wave terminal segment correlated with left ventricular end-diastolic pressure.

A statistically highly significant correlation exists between the values of left ventricular end-diastolic pressure and the dimensions of the terminal segment of the P wave in the electrocardiographic V 1 lead. Values lower than -0.03 mmsec were found only in patients with pathologically elevated left ventricular end-diastolic pressure. In a group of 94 patients with acute transmural myocardial infarction, pathologically low values were found in 43% of the patients on the first day of the disease; on the fifth day of disease the frequency of pathological values of PTF---V 1 sank statistically significantly. A gradual decrease in the values of PTF---V 1 is a sign of bad prognosis in patients with acute myocardial infarction. Changes in the terminal segment of the P wave, at preserved sinus rhythm, can be read off any electrocardiographic curve. Their evaluation offers valuable information about changes in left ventricular end-diastolic pressure, when facilities for catheterization of the patient are not available. This possibility constitutes the main practical value of the method described.

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PubMedDate not supplied

Prostaglandin E1 : electrophysiological safety in patients with congestive heart failure and peripheral arterial occlusive disease. The Alprostadil Investigators.

Prostaglandin E ( 1 ) (PGE ( 1 ) ), the active ingredient of the drug alprostadil-alpha-cyclodextrin, has been effective in mitigating the clinical manifestations of peripheral arterial occlusive disease (PAOD). PGE ( 1 ) often is administered to patients with the potential for developing serious arrhythmias, presenting potential safety hazards if the drug caused or potentiated arrhythmias. However, PGE ( 1 ) has antiadrenergic properties and, theoretically, might have an antiarrhythmic action. Therefore, the effect of PGE ( 1 ) on frequency and severity of atrial and ventricular arrhythmias was evaluated from 48-hour electrocardiographic recordings in patients receiving PGE ( 1 ) therapy for severe PAOD. No significant effects on arrhythmia frequency or severity, and no evidence of proarrhythmia, was apparent after PGE ( 1 ) administration.

Alprostadil↗