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Biomedical subjects

M Ariet

Publications and source records attributed to M Ariet.

33 records · Page 2Linked to original sources
PubMed1983

Determination of ideal body weight for drug dosage calculations.

Formulas for ideal body weight (IBW) in men and women were derived from the Metropolitan Life Insurance Company height and weight tables. Regression determinations of median weight versus height were performed for men and women. A program for a minicomputer was developed to generate plots for small, medium, and large frame sizes and for subjects of all frame sizes. Equations for ideal body weight were derived from the resulting data. For men of all frame sizes, IBW = 51.65 kg + 1.85 kg/inch of height greater than 5 feet. For women of all frame sizes, IBW = 48.67 kg + 1.65 kg/inch of height greater than 5 feet. More accurate estimates of IBW by frame size can be obtained using equations derived from the plots for men and women of each frame size. Estimates of IBW obtained by the widely used empirical method probably contain only minor errors. However, formulas derived from actual height and weight data should be used in pharmacokinetic determination of dosage regimens for some drugs.

Body Height↗
PubMed1982

The instantaneous hinge axis - its reproducibility and use as an indicator for dysfunction.

This study investigated irregularities in hinge movement in 113 subjects. These irregularities were analyzed by computer with an instantaneous three-dimensional "screw axis method." The variation in hinge movement was measured by the dispersion of the hinge axis instant centers. Dispersion of instant centers was greater for muscle pain patients than for the normal, indicating that instant center data could make a contribution to diagnosis and treatment planning.

Adult↗
PubMed1982

Prediction of theophylline dosage regimens from limited serum sampling.

Intravenous aminophylline was administered to 13 subjects (6 normal, 7 with chronic obstructive pulmonary disease), and multiple blood specimens were drawn over an 8-hour period for theophylline analysis. Half of the samples were obtained during the distribution phase of the drug and the remainder during the elimination phase. These data were entered into a computer program that both calculates and graphically displays individual two-compartment pharmacokinetic data, and recommends a dosing regimen. Analysis of these data demonstrates wide variability in the theophylline volume of distribution, half-life, and predicted dosage regimen. Dosage regimens can be individualized by obtaining two specimens for theophylline analysis during the elimination phase after intravenous administration of the drug; these regimens correlate extremely well (r2 = 0.95) with those designed using all the data points.

Drug Administration Schedule↗
PubMed1976

Systems analysis of computerized EKG processing center.

A functional description of a computerized system for analysis of electrocardiograms (EKGs) is presented. Although it is recognized that the diagnostic accuracy of the program is the critical parameter in determining system acceptance, other system features such as quality control, turn around time and cost are shown to be of high importance. A digital simulation of alternative configurations for on-line data acquisition is presented. The simulation predicts the system throughout and wait times in different phases of a telephone EKG transmission for combinations of interfaces, telephone lines and acquisition procedures. These results should be helpful in selecting the appropriate configuration for each special situation.

Computers↗
PubMedDate not supplied

Potential benefits of a computer ECG interpretation system for primary care physicians in a community hospital.

One hundred fifteen ECGs from a hospital service were interpreted by 2 primary care physicians and 2 expert electrocardiographers. When their interpretations were compared with one another and with the Marquette MAC II ECG Interpretation Program, there was great variability. Computer ECG interpretations appeared to benefit primary care physicians most by providing a backup opinion. This second opinion was also of use to expert electrocardiographers. Additional long-term benefits that may be derived from computer systems include improvement of physician interpretation ability, reduction in interpretation time, and standardization of electrocardiographic nomenclature and criteria.

Diagnosis, Computer-Assisted↗