[Heparin therapy in acute ischemic infarction of the vertebrobasilar area].
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Anticoagulants↗
Biomedical subjects
M Arias
Publications and source records attributed to M Arias.
[Syndromes of continuous muscular activity: report of a central case (stiff-man) and a peripheral case (neuromyotonia) associated with neuroborreliosis].
We describe two cases of continuous muscular activity: one which is central (the stiff-man syndrome), and another which is peripheral (neuromiotony), the latter in a patient suffering from diabetic neuropathy and with positive Borrellia burgdorferi serology in the bloodstream, as well as CSF. Both cases reacted favourably to medical treatment. In the first case botulinic toxin was used as a simultaneous treatment for focal pseudodystonia in one foot. Response was good.
Aged↗
[Autoscopy and multiple sclerosis].
A female patient with clinically defined multiple sclerosis presented episodes of audiovisual hallucinations in the form of projections of her own body image speaking to her. EEG and EEG-Holter studies were normal. MRI revealed multiple areas of hypersignals in white matter, particularly in both temporal lobes. The episodes remitted with carbamazepine therapy. We postulate that this phenomenon of autoscopy, which is unusual in multiple sclerosis, may be related to a mechanism of ephaptic transmission in the temporal lobe that is inhibited by carbamazepine, or it may be related to seizure.
Adult↗
Failure to induce nitric oxide production by human monocyte-derived macrophages. Manipulation of biochemical pathways.
Production of nitrix oxide (NO-) by human macrophages is controversial. In the present study, the ability of human monocyte-derived macrophages (M phi) to produce NO- in response to M phi modulators was tested. M phi cultured for up to nine days and stimulated for 48 with different concentrations of LPS and/or IFN-gamma failed to produce significant amounts of NO2- compared to unstimulated cultures. Inhibition of the cyclo-oxygenase pathway with indomethacin did not increase NO2- production by LPS stimulated M phi. Since human M phi lack biopterin, needed for NO- synthesis by murine M phi, human M phi stimulated with LPS plus IFN-gamma were additionally cultured in the presence of neopterin or biopterin. These treatments did not induce NO2- production. Furthermore, simultaneous treatment with indomethacin and neopterin or biopterin also failed to induce NO2- production. However, human M phi, stimulated with IFN-gamma and LPs, produced TNF-alpha suggesting that the lack of increment in NO2- production was not due to an absence of response of M phi to the stimuli used. As an indirect approach to explore the NO- production, human M phi were infected with virulent Mycobacterium tuberculosis H37Rv and simultaneously treated with the competitive inhibitor NGmonomethyl-L-arginine (NGMMA). Mycobacterial intracellular replication was measured by 3H-uracil incorporation. NGMMA did not have any effect on mycobacterial replication. These results further suggest that human M phi do not produce NO- at least by the inducible pathway.
Biopterins↗