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Biomedical subjects

M Arborelius

Publications and source records attributed to M Arborelius.

105 records · Page 6Linked to original sources
PubMedDate not supplied

Angiographic evaluation of scintigraphic abnormalities in screening for pulmonary embolism after total hip replacement.

Among 240 consecutive patients subjected to total hip replacement, 206 underwent perfusion scintigraphy in screening for pulmonary embolism 10 to 14 days after surgery. All patients with perfusion abnormalities (n = 77) also underwent ventilation scintigraphy with a dry 99Tcm microaerosol. The scintigraphic abnormalities were classified according to a detailed coding system and in 50 patients pulmonary angiography was performed within 24 hours for correlation. Emboli were diagnosed in 19 patients at angiography. All patients with ventilated segmental (n = 6) or larger (n = 5) perfusion defects or multiple subsegmental defects larger than half a segment (n = 2) had emboli. Two of 8 patients with abnormally ventilated subsegmental perfusion defects larger than half a segment had emboli. Four of 21 patients with wedge-shaped subsegmental perfusion defects smaller than half a segment or defects with a rounded border towards the hilum and a peripheral extension equal to or less than that of a segment had emboli. In one of them the site of the emboli correlated to the site of the perfusion defect but occurred in normally perfused areas in the remaining 3. Ventilation scintigraphy was of no value in this group of patients. No emboli were found in patients who had areas with decreased but not totally lost perfusion (n = 8). No emboli were diagnosed in 27 lungs with a normal perfusion.

Adult↗
PubMedDate not supplied

Bronchial reactivity and small airway dysfunction in subjects with intermediate alpha 1-antitrypsin deficiency.

Lesions in small airways may cause increased central deposition of inhaled aerosol. This may enhance airway constriction following methacholine (MCh) challenge. Heterozygous alpha 1-antitrypsin deficiency (PiMZ) and smoking may both act on the lung parenchyma and may also influence small airways. We, therefore, have related bronchial reactivity to MCh to the function of the small airways and to smoking habits in 31 normal (PiM) male subjects aged 48-50 years and 34 PiMZ male subjects, all from a population study. A total of 23 subjects with increased bronchial reactivity was found. The number of reacting smokers (14/23) was significantly higher than that of the reacting ex-smokers (7/23) (p less than 0.05) and nonsmokers (2/19) (p less than 0.05). The smokers who had increased reactivity to MCh challenge had significantly higher closing capacity %, RV/TLC %, and volume of trapped gas % than the smokers who did not have increased reactivity. This difference was not seen with regard to closing volume %, slope index, delta N2 %/1, or washout volume. There was no significant difference between the PiM and the PiMZ subjects with regard to any of the lung function variables or the response to the MCh challenge. It is concluded that there may be a correlation between dysfunction of the small airways and increased bronchial reactivity.

Airway Resistance↗