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Biomedical subjects

M Aoshima

Publications and source records attributed to M Aoshima.

At least 73 records · Page 4Linked to original sources
PubMed1987

A yeast gene coding for a putative protein kinase homologous to cdc25 suppressing protein kinase.

A yeast gene termed YKR coding for a putative protein kinase was isolated by using the cloned cDNA for rabbit protein kinase C as a hybridization probe. The encoded protein (YKR), composed of 380 amino acid residues, shows extensive sequence homology to serine/threonine-specific protein kinases from various species in the approx. 320 C-terminal amino acid residues, strongly suggesting that YKR is endowed with a protein kinase activity. The observed homologies to the cdc25 suppressing protein kinase from yeast, the catalytic subunit of mammalian cAMP-dependent protein kinase, and mammalian protein kinase C were 76, 48 and 37%, respectively. Gene replacement experiments showed that YKR itself is not essential for cell proliferation.

Amino Acid Sequence↗
PubMed1985

Beneficial preparatory aortopulmonary shunt for anatomical repair of transposition of the great arteries with intact ventricular septum.

Anatomical repair was successfully performed in an infant with transposition of the great arteries and intact ventricular septum who had previously received a Blalock-Taussig shunt. In this patient, creation of an aortopulmonary anastomosis induced a well-developed left ventricle with concomitant adequately increased pressure and mass. Beneficial aortopulmonary shunt that precedes the anatomical repair in selected patients with simple transposition is discussed.

Aorta↗
PubMed1985

Modified Blalock-Taussig shunt following long-term administration of prostaglandin E1 for ductus-dependent neonates with cyanotic congenital heart disease.

In the treatment of cyanotic heart diseases in neonates who are ductus dependent, the small size of the pulmonary artery and/or subclavian artery often precludes construction of a sufficient Blalock-Taussig shunt. To avoid an emergency operation and to obtain pulmonary and subclavian arteries of adequate size (3 mm), a low dose of prostaglandin E1 was given to 16 neonates for a mean of 47 days (range 26 to 65 days), and a modified Blalock-Taussig shunt operation was performed in neonates whose mean age was 50 days. The pulmonary artery grew significantly (mean 4.5 mm) and the mean diameter of the subclavian artery was 3 mm, which was large enough for a good shunt at the time of operation. There were two late deaths and one operative death. All surviving patients shunts at the mean follow-up period of 22 months. The shunt was constructed on the same side as the ductus arteriosus so that the ductus could be ligated at the same operation in selected cases; the ductus may not close after discontinuation of prostaglandin E1 infusion and may cause uncontrollable congestive heart failure because of excessive pulmonary blood flow, particularly in patients with a univentricular heart. The ductus, dissected in nine patients, was enlarged and elongated in all and was ligated in four patients without complication.

Ductus Arteriosus, Patent↗
PubMed1984

Left ventricular volume as a predictor of postoperative hemodynamics and a criterion for total correction of tetralogy of Fallot.

The effect of preoperative left ventricular end-diastolic volume on hemodynamics after repair and the safety limit of left ventricular end-diastolic volume for total correction of tetralogy of Fallot were studied. Preoperative left ventricular volume was determined in 38 patients according to the area-length method from biplane cineangiocardiograms. The mean left ventricular end-diastolic volume of the 38 patients was 83% +/- 23% of normal. The left ventricular end-diastolic volume of 20 corrected patients (90% +/- 22% of normal) was significantly larger (p less than 0.05) than that of 18 with a systemic-pulmonary shunt (75% +/- 22% of normal). In the corrected patients, the total amount of dopamine required in the postoperative period showed an excellent inverse exponential correlation with the preoperative left ventricular end-diastolic volume (r = -0.826); it showed a poor inverse correlation with the ratio of pulmonary artery to aortic diameter (r = -0.587) and with myocardial ischemic time (r = -0.487); and it showed no correlation with postoperative right to left ventricular systolic pressure ratio (determined at the time of the chest closure) and residual right ventricular-pulmonary arterial pressure gradients. The patients with a left ventricular end-diastolic volume under 70% of normal had severe low-output syndrome after total correction. We recommend a left ventricular end-diastolic volume of 60% of normal as a safety limit for total correction in patients under 2 years of age. In patients over 2 years of age, the safety limit may be larger because there are more collaterals with increasing age.

Cardiac Output↗