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Biomedical subjects

M Aono

Publications and source records attributed to M Aono.

At least 181 records · Page 10Linked to original sources
PubMed1978

Effect of intravenous infusion of somatostatin on gastric, pancreatic and biliary secretion in the rat.

The effect of somatostatin (GH-RIH) on gastric, pancreatic and biliary secretion was examined in the anesthetized rats. Intravenous infusion of the hormone, in graded doses ranging from 1 to 16 microgram/kg/hr, produced a dose dependent inhibition of pentagastrin, 1.5 microgram/kg/hr, induced acid secretion, reaching about 54% of control level at the dose of 16 microgram/kg/hr. Somatostatin, 4, 16 and 64 microgram/kg/hr, inhibited the pancreatic juice volume stimulated by intravenous injection of secretin, 1 u/kg, as a bolus. Somatostastin, 2, 8, 32 and 128 microgram/kg/30 min, did not change the bile flow rate in control period. Somatostatin may play a physiological role in the regulation of the secretory process of the stomach and pancreas.

Animals↗
PubMed1978

Rat gastric secretion studies with synthetic gastrin-like tetrapeptide.

Gastric acid and pepsin secretions were measured in the perfusing rat stomach preparation with sodium-citrate-phosphate buffer, pH 6.6. In anesthetized rat stomach preparation, acid output in both basal and stimulated conditions seemed to be small, but pepsin output was observed even in a short period. In the rats which were fed freely just before use, basal pepsin output was significantly lower than that of fasted rats, although in the basal acid output and in the acid and pepsin output during stimulation in both groups, there was no difference statistically. Intravenous infusion of tetragastrin (1, 2, 4, 8, 16 and 32 microgram/kg/hr) produced a dose dependent acid and pepsin secretions. Tetragastrin, at the dose of 8 microgram/kg/hr, stimulated acid and pepsin output. Acid output was kept constant for three hours, but pepsin output was made to peak within an hour and formed a plateau after 1.5 hours at a level of 30% of peak pepsin output.

Animals↗
PubMed1975

Oxygen transport of colloidal fluorocarbon suspensions in asanguineous rabbits.

In anesthetized, oxygen-breathing rabbits, the entire blood volume was exchanged with a 20% colloidal fluorocarbon fluid suspension of high gas solubility. In contrast to the control animals with acute isovolemic and hypervolemic hemodilution, the fluorocarbon suspension prevented the decrease in arterial oxygen content below a hematocrit of 13%. However, the more pronounced effect of the fluorocarbon suspension on oxygen delivery occurred at higher hematocrits and was due to its efficiency as a plasma expander, since it increased the cardiac output even above the level of the hypervolemic hemodilution group. The fluorocarbon suspension also raised arterial blood pressure and total peripheral resistance due to its increased viscosity. Thus, in mild hemodilution, the fluorocarbon suspension kept oxygen utilization in the normal range by increasing cardiac output, and in extreme hemodilution it improved oxygen utilization by also raising the arterial oxygen content and arterial blood pressure. The survival time of the isovolemic control animals was 31.6 min, it was extended to 57.8 min in the hypervolemic control animals, and the rabbits with the fluorocarbon suspension lived for 124.8 min.

Animals↗