Search PubMed⌕ Search

Biomedical subjects

M Antos

Publications and source records attributed to M Antos.

13 recordsLinked to original sources
PubMed1989

[Kinetics of leukocytes in patients on hemodialysis].

The total numbers of leukocytes and relevant fractions of granulocytes in 51 patients on chronic intermittent hemodialysis were determined. The leukocytes were counted before the beginning, during the third hour of and one to two hours after the hemodialysis. Along with the kinetics of leukocytes the levels of C3 and C4 components of the complement were tested. A decrease of total numbers of leukocytes was observed as well as that of all the fractions of granulocytes during the third hour of dialysis. The intensity of leukopenia depended on the structure of dializer membrane. Observing the components C3 and C4 along with the values of leukocytes there was no association between these two alterations. The authors concluded that leukopenia during the hemodialysis is not caused by complement activation in the contact of plasma with the membrane of the dializer but by the mechanical effect of adhesion or microaggregation of leukocytes on the membrane of the dializer.

Adult↗
PubMed1979

Variations in the level of haematogenous antitumour immunity during progressive tumour growth and spontaneous blood-borne metastatic spread.

Inbred DBA2 mice bearing the syngeneic 1699 mammary tumour in the hind limb were challenged intravenously with 125IUdR-labelled single 1699 cell suspensions, and the amount of radioactivity in the lungs compared 20--24 h later with that in the lungs of normal mice or in those of mice bearing the antigenically unrelated syngeneic SaD2 tumour. An immunologically specific decrease in radioactivity was evident at variable periods of time after tumour induction, depending on the number of cells used to induce the leg tumours, but fell below that in normal mice as the leg tumours progressed beyond a weight of approximately 1 g. As assessed by microscopic scanning of serial histological sections of the same lungs the incidence of spontaneous metastases rose to between 80 and 100% immediately the amount of cell loss from the lungs of the tumour-bearing mice reached that of the normal controls. This extremely rapid series of events does not allow a definitive conclusion as to whether immunity failed and led to metastatic spread or vice versa, but does underline the strong association of immunity with the blood-borne dissemination of tumour cells in this tumour system. Following excision of tumours, in no instance was immunity detected 14 days later, and in a single experiment did not reach detectable limits until 25 days after excision, at a time when the lung metastases were observed mostly to have regressed spontaneously.

Animals↗
PubMedDate not supplied

Antidietary antigen antibodies in the sera of patients with burns as a potential marker of gut mucosa integrity failure.

It was hypothesized that a failure of gut mucosa integrity after burn injury may lead to translocation of food proteins as well as bacteria and endotoxins. Certain, normally digested proteins may stimulate the humoral immune response as they enter the circulation. To test this hypothesis, serum samples from 16 patients with burns and 10 healthy donors were tested for the presence of antigliadin and anti-beta-lactoglobulin antibodies of immunoglobulin M (IgM), IgG, IgA, and IgE classes by means of enzyme-linked immunosorbent assay. Patients and donors remained on a standard diet that included wheat (gliadin) and milk products (beta-lactoglobulin). In the group of six patients with severe burns (mean total body surface area burn = 50%), antigliadin and anti-beta-lactoglobulin IgG and IgA antibodies were detected. In the control group and in 10 patients with small to moderate burns (mean total body surface area burn = 15%), these antibodies were not observed. There was a significant correlation between antigliadin IgG and IgA titers (r greater than 0.9) and anti-beta-lactoglobulin antibodies (r greater than 0.7) in patients with burns. Results suggest immunization by gliadin and beta-lactoglobulin in the group of patients with severe burns.

Adult↗