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Biomedical subjects

M Antonelli

Publications and source records attributed to M Antonelli.

At least 145 records · Page 8Linked to original sources

Blood glycerol meaning in obese patients.

The authors studied the behaviour of blood glycerol concentration after glycerol i.v. infusion in obese and normal subjects. The aim of research was to clarify the meaning of blood glycerol increase observed by some one in obese subjects. Results obtained showed that in obese subjects there is not any abnormal behaviour of blood glycerol concentration after infusion and that in none of patients studied was observed any significative increase of basal blood glycerol concentration values.

Adult↗

Arnold-Chiari malformation detected by unenhanced multiplanar CT scan.

Multiplanar computed tomographic (CT) scanning done without injection of contrast agent detected the nervous tissue abnormalities in 4 patients with Arnold-Chiari Malformation. Comparisons were made between traditional radiological studies and CT scanning. Three cases were confirmed surgically; the fourth case was diagnosed purely by CT scanning. This preliminary study suggests that this new technique should be sufficient to make a positive diagnosis in most cases of Arnold-Chiari malformation.

Adult↗

Immotile cilia syndrome: radial spokes deficiency in a patient with Kartagener's triad.

Mucociliary transport and ultrastructure of nasal cilia in a 13 year old boy with Kartagener's triad, were investigated. Mucociliary transport was significantly delayed (greater than 30 minutes). Electron microscopy showed cilia lacking radial spokes, eccentric central tubules, and a dislocation of one the outer doublets. Dynein arms were present. We consider the radial spoke defect as a distinct congenital anomaly which contributes to the pathogenesis of the "immotile cilia syndrome".

Adolescent↗

Is there a relationship between sex of cystic fibrosis carriers and sex ratio of their offspring?

Data on the offspring of 198 aunts and 179 uncles of 100 cystic fibrosis index cases were analyzed. Aunts showed higher average number of liveborn sons than uncles. No significant difference was observed in the number of liveborn female offspring. When the sample was subdivided with respect to family size, the proportion of liveborn sons of aunts appeared higher than that of uncles in all classes. The present observations suggest that a female carrier may have a higher probability of male offspring than a male carrier and that she may be mainly responsible for the sex ratio deviations previously reported in sibships of cystic fibrosis patients.

Cystic Fibrosis↗

Calcification of the pancreas in cystic fibrosis.

Using the gastric insufflation method, 5 cases of pancreatic calcification have been detected in a series of 60 patients with cystic fibrosis. All patients were over 5 years of age. Four of them showed a diabetic curve at glucose tolerance test and 2 have recently developed frank diabetes mellitus. The value of gastric distension by gas in the radiological detection of pancreatic calcification and the relatively high frequency of such calcification in cystic fibrosis are emphasized. The pathogenesis of the calcific change and its clinical significance are briefly discussed.

Adult↗

[Measurement of the stress deformation ratio in the left ventricle in systole].

Thirty-three subjects, fourteen of which with normal heart, ten with aortic insufficiency and nine with myocardiopathy, were studied by echocardiography and sfigmomanometric arterial pressure measurements. The ejection fraction EF, the left ventricular equatorial wall stress sigma, the corresponding left ventricular strain epsilon and the ratio E = sigma/epsilon have been determined for all subjects. The mean values of these quantities, at the onset of ventricular systole, for normal hearts are: EF = 0.67 +/- 0.05; sigma = (2.67 +/- 0.41) . 10(5) dine/cm2; E = (0.99 +/- 0.15) . 10(6) dine/cm2; for patients with aortic insufficiency: EF = 0.51 +/- 0.09; sigma = (2.74 +/- 1.10) . 10(5) dine/cm2; E = (1.51 +/- 0.69) . 10(6) dine/cm2; for patients with miocardiopathy: EF = 0.41 +/- 0.06; sigma = (4.36 +/- 2.08) . 10(5) dine/cm2; E = (3.20 +/- 1.19) . 10(6) dine/cm2. After a discussion on the significance of sigma and E parameters, it is inferred that E may be a useful measure of ventricular function. This parameter is different for distinct cardiac diseases and, within the limits of the same disease, probably will change according to seriousness.

Adolescent↗