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Biomedical subjects

M Andrzejewska

Publications and source records attributed to M Andrzejewska.

10 recordsLinked to original sources
PubMed2005

Synthesis and antimycobacterial activity of 2-substituted halogenobenzimidazoles.

A series of substituted 2-polyfluoroalkyl and 2-nitrobenzylsulphanyl benzimidazoles was synthesized. The compounds were evaluated for their activity against four Mycobacterium strains; the activities were expressed as the minimum inhibitory concentration (MIC). The substances tested showed appreciable antimycobacterial activity, particularly 5,6-dichloro-2-nonafluorobutylbenzimidazole (2h), and 5-halogeno- (5a-c) and 4,6-dihalogeno- (5d and 5g) 2-(3,5-dinitrobenzylsulphanyl)benzimidazoles, whose MIC values for Mycobacterium kansasii and Mycobacterium avium exceeded that of isoniazide that was used as a reference compound. Relationships between structure and biological activity of the tested benzimidazole derivatives are discussed.

Anti-Bacterial Agents↗
PubMed2005

L-nucleosides containing modified nucleobases.

The synthesis of base modified L-nucleosides is described with pyrrolo[2,3-d]pyrimidines, pyrazolo[3,4-d]pyrimidines, benzimidazoles, and imidazo[1,2-a]-s-triazines as nucleobases. The conformation of the nucleosides is studied and the antiviral activity is evaluated.

Antiviral Agents↗
PubMed2003

The impact of experience of a transplantation center on the outcomes of orthotopic liver transplantation.

The so-called learning factor has been disregarded for many years in analyzing the causes of surgical complications and post-operative mortality; it is also the case for OLT. In our center until April 2003, 209 OLT were performed in 196 patients. We evaluated the impact of experience of the transplantation team on the outcomes of liver transplantation. Thirty-four patients died (mortality rate, 16%) and 1-year survival rate, 64%. Mortality rates varied during different periods of observation due to increasing experience of the transplantation team. The causes of mortality were assessed for a series of 34 patients: it was 75% at the beginning of transplantation procedures while recent deaths have not recently exceeded 10% of cases.

Gallbladder Diseases↗
PubMed2003

Vascular complications after liver transplantation.

Vascular complications following liver transplantation is reviewed based upon literature data and our own results. Our study conclusions are mostly based on literature data, because our center does not have the liver transplantation experience of other centers worldwide. Thus, we may conclude, that the number and character of complications does not differ from those reported by other centers. The enbloc technique used in liver harvesting minimizes the risk of arterial damage in case of vascular anomalies. Recipient retransplantation is the most effective treatment method in cases of hepatic arterial occlusion. Doppler ultrasound examinations are effective to monitor vascular blood flow in the transplanted liver.

Arterial Occlusive Diseases↗
PubMed2003

Alkaline hydrolysis of cladribine.

The kinetics of hydrolysis of 2-chloro-2'-deoxyadenosine (cladribine) was studied at various sodium hydroxide concentrations and temperatures. HPLC analysis of reaction mixtures showed that the main products were 2'-deoxyisoguanosine and 2'-deoxyguanosine. The first one was the result of the hydroxyl anion attack, whereas the presence of the other nucleoside has evidenced the existence of hitherto undescribed rearrangement reaction in purine derivatives.

Adenosine↗
PubMed2000

[Poisonings by selected drugs: analysis of 1995-1999 data files of the Clinic of Acute Poisonings Institute of Occupational Medicine in Łódź].

Over the period of 1995-1999 a total number of 439 cases were admitted to the Clinic of Acute Poisonings, Łódź, Poland, due to poisoning with opiates, opioids, amphetamine, cannabis products, LSD and cocaine. Most of the patients were males, the male to female ratio was 1:1.5 (266 to 173). The distribution by age indicated the persons aged 21-30 yr as the highest risk group, then those aged 14-21 yr. Over the period under study the structure of poisonings changed significantly. Since 1997 the number of poisonings with amphetamine and cannabis products increased dramatically, while that of opiate poisonings declined. Approximately 84% of cases were found to be addicted to a combination of drugs and psychotropic agents, mostly benzodiazepine and ethyl alcohol. Drug addiction was reported by over 80% patients with opiate poisoning, 44.8% with tetrahydrocannabinole poisoning and only 9.5% with amphetamine poisoning. The efficacy of treatment in cases of drug addiction is very low. Repeated treatment was reported by almost 100% of patients who had attempted to quit drug abuse. Among opiate poisoning cases, only 8 out of 45 patients did not question the effectiveness of the withdrawal treatment.

Acute Disease↗
PubMed1980

Strain and sex dependent sensitivity to skin anaphylactic reactions in the mouse.

The strain-dependent variation in sensitivity of mouse skin to passive cutaneous anaphylaxis (PCA) was observed. The results showed that this variation is not connected either with mast cell number and histamine content in the skin of different mouse strains or with the concentration of non-specific IgE on skin mast cells of these strains. Thus, other factors determining the susceptibility of mouse strains to PCA must exist.

Anaphylaxis↗
PubMedDate not supplied

Imaging techniques in patients with biliary obstruction.

The most frequent causes of cholestasis include choledocholithiasis and neoplasms (pancreatic head carcinoma, ampullary carcinoma, cholangiocarcinoma). The authors discussed imaging modalities currently applied in the diagnostics of patients with suspected obstruction biliary tract obstruction. Special attention was paid to the efficacy of these techniques in detecting the obstruction and determining its level and nature. In general, US or CT are first performed in patients with cholestasis. The use of percutaneous cholangiography and retrograde cholangiopancreatography is often limited to therapeutic interventions. Magnetic resonance offers images similar to both conventional cholangiography and computed tomography. This technique offers complex evaluation of bile ducts and other abdominal organs.

Bile Duct Neoplasms↗