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Biomedical subjects

M Andrew

Publications and source records attributed to M Andrew.

241 records · Page 14Linked to original sources
PubMedDate not supplied

Alpha 2-adrenoceptors and I1-imidazoline binding sites: relationship with catecholamines in women of reproductive age.

A comparison is presented between plasma catecholamine concentrations and platelet [125I]-p-iodoclonidine binding sites in 16 healthy women. Blood samples were obtained at six regularly spaced intervals over two consecutive menstrual cycles from healthy women with regular menstrual periods. Although no cycle-related changes were observed per se, there were significant correlations between the platelet binding sites and plasma norepinephrine and epinephrine concentrations. The densities of platelet alpha 2-adrenoceptors were negatively correlated in an exponential fashion (r2 = 0.694, P = 0.009) with plasma epinephrine concentrations, implying agonist-induced downregulation. On the other hand, platelet I1-imidazoline binding sites were positively correlated with plasma concentrations of norepinephrine in a linear fashion (r2 = 0.326, P = 0.021). This is the first indication that I1 binding sites might be upregulated by a physiological factor. Furthermore, the data suggest that elevations in plasma norepinephrine might explain reports of upregulated I1 binding sites in depressed patients.

Adult↗
PubMedDate not supplied

Effect of bupropion on immunodensity of putative imidazoline receptors on platelets of depressed patients.

A substantial number of studies have demonstrated increased imidazoline receptors (I1 binding sites) on platelets of depressed patients and downregulation following antidepressant treatments. Herein, imidazoline receptor binding protein (IRBP) antiserum was used to quantify imidazoline receptors on platelets of depressed patients before and after treatment with the atypical aminoketone antidepressant, bupropion. Western blots revealed an increase in IRBP-immunodensity (p = 0.01, two-tailed) in a 33 kDa protein band in untreated depressed patients (n = 21) as compared with controls (n = 17). This band has been positively correlated with I1 binding sites on platelets. Following 6 weeks' treatment with bupropion, IRBP-immunodensity was downregulated in depressed patients (p = 0.03, paired t-test); predominantly in responders (p = 0.005). Patients non-responsive to bupropion (n = 5) were significantly different from responders (p = 0.05) by exhibiting no elevation in IRBP-immunodensity at pre-treatment and no downregulation of the 33 kDa band after treatment. IRBP-immunodensity was negatively correlated (r = -0.79, p = 0.01) with plasma concentrations of bupropion and its metabolites at week-4 of BUP treatment. Thus, a 33-kDa IRBP on platelet plasma membranes is elevated in depression and normalized in responders to bupropion.

Adolescent↗
PubMedDate not supplied

The dilemmas of experiential teaching: toward an interpretive approach.

Continuing education in nursing uses the experience of the learner as a basis for the examination of practice issues. The unique and personal nature of this experimental learning is, however, particularly problematic where assessment of the learner or the course is required. This article offers part of the findings from an evaluative, ethnomethodological study into the reflections of learners attending an experiential course in communication in palliative care. In the part of the study described here, the critical perceptions of three learners following one experiential exercise are compared with the stated aims of the facilitators and their subsequent actions. The analysis uses the conceptual framework of Schön's reflection-in-action. It is suggested that an interpretive approach toward teaching in the experiential domain may lead to a more relevant assessment of learning.

Clinical Competence↗
PubMedDate not supplied

Physiological and perceptual responses during household activities performed by healthy women.

OBJECTIVE: The purpose of this study was to describe the physiological and perceptual responses during two physically demanding household tasks: cleaning the bathroom and vacuuming the living room. It also examined the relationship between predicted aerobic fitness and the physiological responses during the two tasks. METHOD: Seventeen healthy women between 30 and 50 years of age volunteered as participants. They were interviewed to gather demographic information required for prediction of aerobic fitness and observed while performing each task for 17 min to 20 min in their own home. RESULTS: The heart rate, an index of circulatory strain, varied considerably among the participants and was moderately high during both tasks. Vacuuming the living room had a higher level of circulatory strain and perceived exertion than cleaning the bathroom. An inverse relationship existed between the predicted aerobic fitness and heart rate responses during the two tasks. CONCLUSION: Routine household tasks result in a significant circulatory strain in healthy women. Persons with high levels of aerobic fitness experience a lower degree of circulatory strain.

Adult↗
PubMedDate not supplied

Alcoholism.

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Alcoholism↗