Biomedical subjects
Publications and source records attributed to M Andrejak.
Authors report one case of death caused by anaphylactic collapsus after a fluorescein angiography. They make a review of all the complications described and particularly insist about the anaphylactic reactions. They conclude on the modalities of treatment.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
A clinical study and dosages of ceftriaxone were performed during the treatment of 14 ascitic fluid infections. Fourteen cases of ascitic fluid infection were treated with ceftriaxone at doses of 2 grams daily. The isolation of the causative organisms was obtained in 11 out of 14 cases by systematic culture of the ascitic fluid in hemoculture bottles with aerobic and anaerobic medium. Of 11 evaluable infectious episodes ten were cured. Ceftriaxone diffuses rapidly in the ascitic fluid because, within the first hour; mean concentrations were already of 18.6 micrograms/ml largely exceeding the usual MIC for these organisms. A good tolerance for the drug, the well spaced rythm of infections preventing unnecessary parenteral treatment in cirrhotic patients, and its effectiveness against Enterobacteriaceae justify its choice in the treatment of ascitic fluid infections with sensitive organism.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Diltiazem has been reported to decrease or not to affect digoxin elimination. The effects of diltiazem on steady state concentrations of digoxin was evaluated in eleven patients with congestive heart failure receiving this drug for at least two weeks. The mean trough digoxin was 1.11 +/- 0.18 ng/ml before the coadministration of diltiazem (180 mg/day). This concentration increased to 1.54 +/- 0.22 ng/ml after three days and to 1.54 +/- 0.23 ng/ml after seven days of coadministration (P less than 0.01). Clinically, no patient showed signs of digitalis toxicity. Creatinine clearance was unchanged. The present results show that when diltiazem is added to a regimen that includes digoxin, steady state concentrations of this glycoside may increase.
Explore the source record for details and available documents.
The purpose of the study was to compare the renal effects of low doses of exogenous dopamine to assess the responsiveness of renal dopaminergic receptors in normotensive and hypertensive subjects. Eight hypertensive patients and seven normotensive volunteer subjects were studied. Inulin and para-aminohippuric (PAH) clearances, natriuresis, and fractional excretion of sodium increased significantly after intravenous dosing with dopamine (2 micrograms/min/kg) in both groups. These increases were significantly higher in hypertensive than in normotensive subjects: 31.8% +/- 3.7% vs. 16.2% +/- 1.2% for inulin clearance (P less than 0.01), 83.3% +/- 10.5% vs. 41.1% +/- 3.4% for PAH clearance (P less than 0.01), and 331% +/- 38% vs. 216% +/- 26% for natriuresis (P less than 0.01). These findings suggest hyperresponsiveness to dopamine during hypertension. This enhanced response to exogenous dopamine can be considered as a further argument favoring the existence of a deficit in dopaminergic activity during hypertension. Dopamine also induced a significant reduction in blood pressure and increased heart rate in hypertensive subjects but no significant change in blood pressure and heart rate occurred in normotensive subjects.
Forced expiratory volume in the first second (FEV1) and serum theophylline levels were measured comparatively in 26 patients with stable bronchial asthma after a 240 mg theophylline infusion. The mean (+/- s.e.m.) elimination half-life and clearance of theophylline were 6.37 +/- 2.03 hours and 0.78 +/- 0.31 ml/min/kg respectively. A bronchodilator response (more than 20% increase in FEV1) was obtained in 17 patients whose pretreatment FEV1 was less than 30% of predicted normal values. No significant bronchodilator response was obtained in the other patients. There was no relationship in responders between changes in FEV1 and simultaneous serum theophylline levels. Maximal ventilatory response was apparent 1 to 2 hours only after the theophylline peak concentration.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The case of a 28-year-old epileptic woman, treated for 3 months with carbamazepine and who developed jaundice, fever and exfoliative dermatitis is reported. Biological investigations showed an increase in the activity of serum transaminases and alkaline phosphatases as well as in the blood eosinophilic count. Liver biopsy revealed centrolobular necrosis and cholestasis with portal inflammatory infiltrate. Drug challenge was followed by the rapid recurrence of clinical and biological signs. The definitive outcome was favorable. The analysis of the 12 previously published cases, and particularly the frequency of granulomatous hepatitis, suggests an immunoallergic mechanism for the development of carbamazepine hepatitis.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Plasma renin activity (PRA), plasma aldosterone (PA) and plasma catecholamines were measured in 3 groups of women with pregnancy of 20-38 weeks: group I of 16 normotensive controls, group II of 17 women with rest responding hypertension (RRH) and group III of 18 women with permanent hypertension (PH) (supine blood pressure greater than 140-90 mmHg after 8 days of rest, disappearing after delivery). Studies were realized on fasting ambulatory women on a normal salt diet. PRA (mean +/- SEM) was significantly higher in the RRH group than in the control and PH groups (15,8 +/- 2,3 ng/ml/h versus 6,7 +/- 0,5 and 8,9 +/- 0,9). PA was higher but not significantly in the RRH group (736 +/- 122 versus 533 +/- 52 and 502 +/- 103 pg/ml). Plasma epinephrine (PE) and norepinephrine (PNE) were significantly higher in the PH than in the control and RRH groups. 135 +/- 28 pg/nl versus 56 +/- 13 and 63 +/- 17 for PE and 387 +/- 91 versus 206 +/- 32 and 200 +/- 47 pg/ml). These data suggest that PH is linked with activation of the adrenergic system whereas RRH is linked with activation of the RAA system.