Joint fluids and culture supernatants of synovial tissue were examined for the presence of two lymphokines. Migration inhibitory activity was found in 16 of 22 rheumatoid fluids (73%), in 3 of 15 osteoarthritis fluids (20%), and in 3 of 11 fluids from patients with various inflammatory arthritides (27%). Blastogenic activity was present in 14 of 15 rheumatoid fluids and in 1 of 7 nonrheumatoid effusions. The active materials eluted with the third peak from Sephadex G-200 and were therefore smaller than immunoglobulin or immune complexes. These findings suggest that lymphokine-like substances were present in effusions and synovial tissue of most patients with rheumatoid arthritis and some patients with other forms of chronic synovitis.

Arthritis, Reactive↗

PubMedDate not supplied

A case of esophageal lipoma diagnosed by computed tomography.

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Esophageal Neoplasms↗

PubMedDate not supplied

[Juvenile rheumatoid arthritis of a systemic form in a young infant].

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Arthritis, Juvenile↗

PubMedDate not supplied

[Idiopathic hypereosinophilic syndrome].

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Anti-Bacterial Agents↗