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Biomedical subjects

M Anderson

Publications and source records attributed to M Anderson.

554 records · Page 31Linked to original sources
PubMedDate not supplied

[Diagnostic certainty in intestinal amebiasis in Managua].

Three surveys were carried out in Managua. Nicaragua. In the first one it was found that 71% of the intestinal amebiasis cases of obligatory notification had no comparable diagnostic foundations; in the second one, 11.7% of the laboratory diagnoses as Entamoeba histolytica referred by 4 health centers were correct; and in the third one, it was obvious that only 9.4% of the doctors knew well what intestinal amebiasis is. The results suggest that intestinal amebiasis is being diagnosed excessively in Managua.

Animals↗
PubMedDate not supplied

Glioblastoma multiforme: MR imaging at 1.5 and 9.4 T after injection of polylysine-DTPA-Gd in rats.

Polylysine-DTPA-Gd, a new MR contrast agent, was injected into the aorta of rats 7 days after C6 glioblastoma was implanted in their brains; MR imaging was performed 3 days later. The imaging was done at two field strengths: (1) 1.5 T with a 3-mm slice thickness and in-plane resolutions of 600 microns and (2) 9.4 T with a 125- or 500-microns slice thickness and in-plane resolutions of 95 microns. In animals injected with polylysine-DTPA-Gd (1 microgram or more per rat), the T1-weighted images and mixed T1, T2 images of the C6 glioblastoma revealed a higher signal intensity at the marginal region between tumor and normal brain than that seen in surrounding normal brain. The central tumor region had a low signal intensity. The concentration of Gd in the C6 glioblastoma, after injection of 1 microgram polylysine-DTPA-Gd per rat, was calculated to be 0.14 mumol/l. The central tumor region also had a low signal intensity in animals that were not injected with the contrast agent, but the margin between tumor and normal brain was resolved poorly, if at all. The polylysine-DTPA-Gd revealed the microvasculature of the C6 glioblastoma in the 125-micron-thick slices obtained at 9.4 T. This is the first study to reveal the utility of the 9.4-T MR imager for examination of glioblastomas in situ and to demonstrate the utility of polylysine-DTPA-Gd as a contrast agent for the definition of the margin between glioblastoma and normal brain tissue.

Animals↗
PubMedDate not supplied

Opti-Free chemical disinfectant: a safety study with various soft contact lenses.

A 6-month, Phase I clinical study evaluated Opti-Free, a new polyquaternium-1 chemical disinfectant intended for use with all types of soft contact lenses. Fifty-one patients were enrolled and divided into two groups. Group A used the product under exaggerated conditions, with daily exposure of Durasoft 3 (55%) and Hydrocurve II (55%) medium water content, ionic lenses to 5 mL of Opti-Free for 16 hours. Beginning on day 15, group A patients began a normal daily use schedule. Patients in group B wore CSI (38%), Permalens (71%), and Softcon (55%) contact lenses and used the regimen under normal daily use conditions throughout the study. The result indicate that Opti-Free is safe and effective under both normal and exaggerated use conditions. The implications of these data for patient safety are discussed.

Contact Lenses, Hydrophilic↗
PubMedDate not supplied

The bright pituitary gland--a normal MR appearance in infancy.

Signal intensities of the pituitary gland were measured on T1-weighted sagittal MR images of 25 patients younger than 20 years old. We found that the signal intensities in the eight patients who were 8 weeks old or younger were higher (shorter T1) than those in the 17 older patients. We also noted a difference in the signal intensities across the pituitary gland, the signal being higher in the posterior part of the gland than in the anterior part. We attribute the high signal intensities to the rapid intrauterine pituitary growth, so that at term pituitary protein synthetic activity is at a maximum. Possibly, an increase in the bound fraction of the water molecules of the gland may also be present in the neonatal pituitary as compared with the older gland, but this remains to be proved. The higher signal in the posterior pituitary gland may be due to lipid in the pituicyte cells of the posterior pituitary gland.

Adolescent↗