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Biomedical subjects

M Amemiya

Publications and source records attributed to M Amemiya.

38 records · Page 3Linked to original sources

[An analysis of simple reaction time in mentally retarded and nonretarded children matched on mental age: examination using intertrial interval as a variable].

The simple reaction times (RTs) in mentally retarded children and nonretarded children matched on mental age (MA) were analyzed, and the relationship between mental ability and RT performances was discussed. RTs in both groups were obtained under three temporal conditions. In Experiment I, it was found that: (a) The shorter intertrial interval (ITI), the shorter RTs in both groups and (b) in the retarded group, RTs of MA5 and MA6-8 subjects were significantly different, presumably because of motor and/or sensory disabilities in the younger subjects, irrelevant to mental ability. In Experiment II, different response characteristics were found for both groups under the complex temporal condition. Retarded subjects showed remarkably slow RT only on those trials in which a long ITI was followed by a short ITI. Nonretarded subjects had remarkable variation in RT over all trials. It was inferred that different psycho-behavioral characteristics of the subjects of both groups were reflected in the different response tendencies observed.

Adolescent↗

Suppressive effects of central opioids on delayed type hypersensitivity to trinitrochlorobenzene: comparative study with morphine and electroacupuncture.

We reported previously that electroacupuncture (Acu) applied to the acu-point equivalent to GV4 in the mouse just before the 2,4,6-trinitrochlorobenzene (TNCB) challenge suppressed the delayed type hypersensitivity (DTH) through endogenous opioidergic systems in the brain, and the pituitary was pivotal in this immunosuppression. The purpose of the present study was to compare the suppressive effects of Acu with those of single, acute doses of morphine on TNCB-DTH in intact and hypophysectomized (HPX) mice. Subcutaneous morphine 10 mg/kg in ddY mice, 30 mg/kg in BALB/c mice or intracisternal morphine 40 micrograms/mouse in BALB/c mice given just before TNCB challenge suppressed (40-53%) the maximal extent of ear swelling at 24 hrs after challenge in intact mice. In HPX mice, the suppressive effects of intracisternal morphine 10 and 100 micrograms/mouse were less pronounced than those observed in intact mice and there was no significant difference between intact and HPX groups. In addition, suppressive effects observed with Acu or subcutaneous morphine (30 mg/kg) were effectively antagonized by pretreatment with intracisternal naloxone at a dose of as low as 2 micrograms/mouse. Naloxone alone had no effect of its own. These results suggest that 1) the activation of opioid receptor-mediated pathways in the brain, which occurs when opioids are endogenously released (Acu) or exogenously given (morphine), is important in the suppression of TNCB-induced DTH, a cell-mediated immune response, and 2) the pituitary is less pivotal in the suppressive effects of acute morphine than in those of Acu.

Animals↗