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Biomedical subjects

M Alvarez

Publications and source records attributed to M Alvarez.

At least 379 records · Page 21Linked to original sources
PubMed1982

[Therapeutic trial with allopurinol in progressive muscular dystrophy (author's transl)].

Authors present a therapeutic trial with allopurinol on Duchenne muscular dystrophy. On an initial stage of three months they compare the effect of this drug with a placebo, finding no significant results. Afterwards they compare at six weeks, three months and six months the effects on muscle power, chronometered physical exercise and values of CPK without obtaining significant results. The changes on urate serum, and relation urine urate/creatinine are significant at six weeks, three months and six months of treatment.

Adolescent↗
PubMed1981

Sugar derivatives and liver mitochondria. V - Effect of 6-O-benzoyl-3-deoxy-3-fluoro-1,2-O-isopropylidene-alpha-D-glucofuranose.

Using conventional polarographic and mannometric techniques for assaying oxidative phosphorylation and oxygen uptake in isolated rat liver mitochondria, it was observed a decrease in ADP:O ratio and RC coefficient as a function of treatment with 6-O-benzoyl-3-deoxy-3-fluoro-1,2-O-isopropylidene-alpha-D-glucofuranose, using succinate and alpha-ketoglutarate as substrates. The enzymes activities of different segments of the respiratory chain, indicated an inhibition of NADH-oxidase activity as a result of treatment with 6-O-benzoyl-3-deoxy-fluoro-1,2-O-isopropylidene-alpha-D-glucofuranose. The oxidation of NADH-linked substrates by rat liver mitochondria was depressed by the compound used, while the succinate oxidation was increased.

Animals↗
PubMed1979

Sugar derivatives and liver mitochondria. I. - Effect of methyl-3,5-di-O-benzyl-2-chloro-2-deoxy-D-arabinofuranoside.

Effect of fifteen sugar derivatives on oxygen uptake and oxidative phosphorylation by liver mitochondria were tested. Full details of the possible mechanism of action of methyl-3,5-di-O-benzyl-2-chloro-2-deoxy-D-arabinofuranoside (VI) was presented. This sugar derivative seems to act as inhibitor of the electron transport in the respiratory chain and as an uncoupler.

Adenosine Triphosphate↗
PubMed1979

Sugar derivatives and liver mitochondria. II. Effect of beta-penta-O-acetyl-D-galactopyranose.

beta-penta-O-acetyl-D-galactopyranose stimulated succinate oxidation in intact liver mitochondria (100%), in broken mitochondria (50%) and in EP1 particles (20%), no effect was observed on purified succinic dehydrogenase. This compound enhances the oxidation of succinate in the presence of Ca2+ and ATP; no effect appeared in the absence of calcium. beta penta-O-acetyl-D-galactopyranose prevents the reversal of Ca2+-induced swelling by EGTA. It seems that this sugar derivative would act, in some way, in the efflux of calcium from mitochondria leading to an accumulation of this bivalent ion in the mitochondria.

Adenosine Triphosphate↗
PubMed1977

Evidence for the presence of phosphoriboisomerase and ribulose-1,5-diphosphate carboxylase in extracts of Desulfovibrio vulgaris.

Cell extracts of Desulfovibrio vulgaris were found to incorporate 14CO2 into acid-stable products when ribose-5-phosphate or ribulose-1,5-diphosphate was used as a substrate. This CO2 fixation required adenosine triphosphate and produced 3-phosphoglyceric acid as one of the products. The assimilation of CO2 by pentose phosphates was unrelated to the pyruvate-CO2 exchange reaction. The pyruvate-CO2 exchange did not require adenosine triphosphate, did not produce phosphorylated compounds, and, unlike the pentose phosphate system, required an acidic protein fraction for activity.

Adenosine Triphosphate↗