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Biomedical subjects

M Altomare

Publications and source records attributed to M Altomare.

31 records · Page 2Linked to original sources

Post-natal development of factor II (pre-prothrombin and prothrombin) in man.

Postnatal development of factor II molecule has been evaluated by three different methods in infants and children from 15 days to 7 years of age. The immunochemical determination of factor II showed that the plasma levels of this factor reached the lowest adult values between 4-7 months of age and rose slowly for all the first year; after this age the plasma concentration was steady. The adult range was reached from 15 to 120 days of age when the factor II was evaluated by the method of Owren and Aas (19) and by staphylocoagulase reagent.

Age Factors

Postnatal development of prekallikrein (Fletcher factor) in man.

The aim of the present study was to determine the concentration of plasma prekallikrein in healthy infants during the first year of life. Prekallikrein levels evaluated by a chromogenic substrate assay were low in the first 15 days of life and increased progressively from the third week of life, reaching normal adult values after the third month of life. The low levels of prekallikrein during the neonatal age reflect the impaired ability of liver cells to synthesize proteins.

Adult

[Buprenorphine in the analgesic treatment of patients subjected to bladder mapping].

Experience with 20 patients suffering from prior papillary neoplasia of the bladder, already treated with TUR and then subjected to control vesical mapping exploiting the analgesic effect of a new drug buprenorphine hydrochloride administered i.v. is reported. Changes in cardiorespiratory variables are examined. The data show that buprenorphine offers good pain tolerance; the absence of respiratory depression suggests that it could be used on a larger scale in patients suffering from cardiorespiratory pathology undergoing multiple vesical biopsies.

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