Total protein and sialic acid levels were determined in the supernatant of serum treated with perchloric acid. Patients with either localized or advanced metastatic malignancy have significantly elevated mean serum values. The highest levels occur in patients with lung, GI, GYN cancer, lymphoma and malignant melanoma. Patients with leukemia and multiple myeloma have slightly elevated values, but they were not significantly different from normal. Patients following curative surgery have normal values while patients in clinical remission following chemotherapy have elevated mean serum protein and NANA levels. Elevated values also occur in patients with benign tumors and 12% of patients with nonmalignant disease. Tumor cells appear to shed macromolecules which contribute to the observed elevation of serum protein and sialic acid levels.

Adult↗

PubMedDate not supplied

[An accessory musculus soleus (symptomatic and asymptomatic). The CT findings].

The authors have reviewed 90 CT exams of the foot to identify the presence of the accessory soleus muscle, an anatomic variant corresponding to the finding of a medial backtibial tumefaction, often aching, especially of the Achilles-calcaneal-plantar system. In these cases, US is generally required to demonstrate the alteration, which was an occasional finding in the past, and to exclude the presence of inflammatory or expansile processes of the soft tissues. The accessory soleus is characterized by the presence of accessory muscle fibers, which, in variable number, caudally make for the medial aspect of the calcaneus from the antinode of the soleus muscle. The anatomic variant is much better evidenced by CT, more frequently employed than MR imaging, thanks to its easier approach. As a matter of fact, both methods are capable of defining the relationships with the adjacent tendinous-vascular-nervous structures, involved by mechanical friction in the event of muscle hypertrophy due to overload. Indeed, the review of CT examinations has pointed out a relative relationship between volumetric changes in the soleus and nonphysiological functional demands, giving further evidence of its specific role in the efficiency of the Achilles-calcaneal-plantar system. Therefore, the report in asymptomatic cases is an important prognostic factor which allows the correct clinical picture of subsequent painful symptoms.

Adolescent↗

PubMedDate not supplied

[Alcoholic epilepsy. Clinico-electroencephalographic analysis of 48 cases].

Various clinical pictures may be identified within the relationship between alcoholism and epilepsy: a) epilepsy existing prior to the drink habit in which attacks are facilitated by intake of alcohol: b) convulsive syndrome coming on following prolonged intake of alcohol (real alcoholic epilepsy); c) convulsive attacks arising after acute intake of alcohol. Within the field of real alcoholic epilepsy two forms can be distinguished. One is generally reversible and arises 5-10 years following the start of the alcohol habis, the other tardive, starting years later irreversible). These pictures probably have different aetiopathogenetic mechanisms and this implies a different therapeutic approach.

Adult↗

PubMedDate not supplied

[Aggressiveness in humans].

Aggressiveness is a deeply-rooted feature of human biology. Its underlying mechanisms can be analysed doctrinally from the biological standpoint, in the light of physiological, clinical and pharmacological data, the ecological standpoint, wherein comparison is made with the behaviour patterns observed in animals, and the psychological standpoint, which is strongly influenced by psychoanalysis theory in explaining the reasons for aggressive behaviour. Reference is also made to the form taken by aggressiveness in children, adults and persons with neurological and mental diseases. The ways in which pathological aggressiveness can be treated are discussed.

Aggression↗

PubMedDate not supplied

[A cluster of mucolipidosis III in a village of Calabria].

The authors report three cases of patients with clinical findings of Mucolipidosis III. Contractures of joint, stiffness of the hands short stature and coarse faces were observed. The lisosomal enzyme activities in serum and leucocytes were measured. The same activities were measured in extracts and by means of cultured skin fibroblast cells. These data are concordant with literature. These patients come from a Calabrian village of 100 habitants 90% of whom have the same surname.

Adult↗

PubMedDate not supplied

[Ossifying fibroma of the tibia and problems concerning the differential diagnosis with other osteofibrotic lesions of the long bones].

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Adult↗

PubMedDate not supplied

[Risk factors in cerebral apoplexy. Epidemiological study].

Acute cerebral vascular diseases are of social as well as clinical interest, since, together with myocardial infarct, they constitute the prime cause of death. Yet their treatment is still confined to the combatting the collateral factors of cerebral damage, since drugs of an aetiological type cannot be employed. The study of the aetiopathogenetic factors of cerebral infarct is thus of considerable importance in the establishment of its prophylactic management. An epidemiological assessment was made of prior risk factors: arterial hypertension, heart disease, and changes in fat and sugar metabolism in 1748 cases of acute cerebral vasculopathy. The data obtained are compared with those in the literature.

Acute Disease↗