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M Albert

Publications and source records attributed to M Albert.

191 records · Page 11Linked to original sources
PubMedDate not supplied

Statistical assessment of perceptual CT scan ratings in patients with Alzheimer type dementia.

Three neuroradiologists perceptually evaluated CT of 24 patients with Alzheimer type dementia and 22 normal control subjects and made a dichotomous judgment for each case (i.e., normal control or Alzheimer type dementia). The mean percentage of patients correctly classified was 83.3%. The neuroradiologists also completed perceptual ratings on each scan. Thirteen regions were rated for atrophy on a scale of 0-4. Discriminant function analyses of several sets of perceptual atrophy ratings (optimized on an exploratory set and evaluated on a test set) showed that the perceptual ratings of temporal lobe regions produced an average accuracy of 88.57%. In contrast, only 74.26% of the cases were correctly classified when the discriminant functions were based on perceptual ratings of midventricular and supraventricular areas. Linear measures of atrophy correctly classified only 65.20% of the subjects. The results suggest that atrophy ratings of brain regions that show the characteristic macroscopic neuropathological changes of Alzheimer disease may be used by neuroradiologists to reach more accurate diagnostic decisions.

Aged↗
PubMedDate not supplied

Influence of the concentration of motile sperm inseminated on the ovum penetration assay results: toward a standardized method.

The influence of the concentration of motile sperm inseminated on the zona-free hamster egg penetration rate has been studied. In 3 fertile men, the higher the concentration of motile sperm inseminated, the higher the ovum penetration rate. This correlation emphasizes the usefulness of standardizing the technical conditions under which the ovum penetration assay is performed. It is also suggested to refer to a standard curve for results analysis. In the 22 patients studied, the outcome of the heterologous ovum assay was in most cases related to the initial sperm parameters. However, some disagreement was also observed. In the absence of a correlation between the initial sperm parameters and the ovum penetration rates, further investigation is needed in order to either more precisely determine the aetiology of unexplained couple infertility, or, in case of intrauterine insemination or in vitro fertilization, to better understand the conditions under which spermatozoa are capacitated in vitro.

Animals↗
PubMedDate not supplied

Oral physostigmine as treatment for primary degenerative dementia: a double-blind placebo-controlled inpatient trial.

Twenty-three patients with primary degenerative dementia (Alzheimer's disease) were administered an optimal dose of oral physostigmine and placebo, each for a 1-week period, under double-blind conditions on a research unit of a general hospital. Each patient served as his or her own control. The optimal dose of physostigmine for each patient was determined previously by a dose-finding phase. There were no significant group differences on a number of neuropsychological tests. Along with other studies in the literature, this study casts serious doubt on the efficacy of short-term administration of oral physostigmine when used alone in an attempt to ameliorate cognitive dysfunction in Alzheimer's disease patients. The possibilities that physostigmine may slow the course of the disease or may acutely improve symptoms when combined with other agents are discussed.

Administration, Oral↗
PubMedDate not supplied

Use of computerized CT analysis to discriminate between Alzheimer patients and normal control subjects.

A newly developed computerized technique was used to analyze the CT scans of 49 patients with dementia of the Alzheimer type and 31 normal control subjects. Nine brain regions distributed across five CT slices were evaluated for each individual. For the purpose of analysis, the patients and controls were divided into an exploratory set and a test set. Several discriminant functions were conducted on the exploratory set and applied to the test set. The combination of variables that focused on regions in the temporal lobe was most accurate in differentiating Alzheimer patients from controls (94%). This degree of accuracy was achieved only when subjects younger than 65 years old were analyzed separately from those 65 years old and older. The newly developed computer software program was able to discriminate between independently selected groups of Alzheimer patients and control subjects. The program was most effective when the analysis emphasized regions in the temporal lobe and when subjects younger than 65 years old were analyzed separately from those 65 years old and older.

Aged↗
PubMedDate not supplied

[Peritoneal complications during continuous ambulatory peritoneal dialysis: surgical aspects].

The principal complication of continuous ambulatory peritoneal dialysis (CAPD) is peritonitis in most cases benign and treated effectively by local, specific antibiotic therapy. In some cases, however, the infection fails to respond to medical treatment and surgical exploration occasionally reveals serious lesions such as sclerosing peritonitis or an intestinal perforation. Prognosis is dependent not only on the extent and severity of the lesion but also on the rapidity of operative intervention. The development of an appendicitis, often masked by early antibiotic therapy, represents a particular course of peritoneal infection during CAPD.

Adolescent↗
PubMedDate not supplied

[AIDS: a world, a desire].

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Acquired Immunodeficiency Syndrome↗