Biomedical subjects

M Alam

Publications and source records attributed to M Alam.

294 records · Page 17Linked to original sources

PubMedDate not supplied

Isolation of the cembranolide diterpenes dihydrosinularin and 11-epi-sinulariolide from the marine mollusk Planaxis sulcatus.

Marine mollusks have been identified as a rich source of novel compounds. The diversity of the chemical nature of these compounds can be partially attributed to the dietary sources inasmuch as mollusks are known to concentrate selectively compounds present in their diet. Although cembranolide diterpenses have been isolated in ever-growing numbers from a variety of marine as well as terrestrial sources, there is only one report about their presence in a marine mollusk. In this communication, we report the isolation of dihydrosinularin and 11-epi-sinulariolide from the mollusk Planaxis sulcatus Born. Dihydrosinularin and 11-epi-sinulariolide acetate have been isolated previously from soft corals which, together with gorgonians, are the richest sources of marine cembranoids. It should be pointed out that this is the first report on the occurrence of the parent 11-epi-sinulariolide in a marine invertebrate. It is expected these diterpenes are of dietary origin although the possibility of biotransformation of a precusor by the mollusk cannot be ruled out at this time. Both dihydrosinularin and 11-epi-sinulariolide have been reported to have marginal antineoplastic activity against P-388 lymphocytic leukemia.

Antineoplastic Agents↗

PubMedDate not supplied

Tuberous xanthomas in sitosterolemia.

Sitosterolemia is an autosomal recessive lipid disorder in which plasma plant sterol levels are extremely elevated and cholesterol levels are often elevated but may be normal. Clinically sitosterolemia is characterized by xanthomas, premature vascular disease, and arthritis. Adolescent boys and girls with sitosterolemia are susceptible to fatal cardiac events. Dermatologists may have a vital role in the diagnosis of this rare but serious condition because early detection and treatment are important in preventing the associated atherosclerotic heart disease. We present a 7-year-old girl with sitosterolemia and tuberous xanthomas.

Anticholesteremic Agents↗

PubMedDate not supplied

Lichenoid eruption following hepatitis B vaccination: first North American case report.

Lichen planus is often found in association with a variety of underlying conditions. In particular, liver diseases such as primary biliary cirrhosis, primary sclerosing cholangitis, hepatitis C, and hepatitis B have been implicated in cutaneous lichen planus. Of interest, there is mounting evidence that lichen planus-like eruptions can occur following administration of the hepatitis B vaccine, which has recently become a routine immunization in many parts of the world. We present what we believe to be the first North American case of lichenoid drug eruption associated with the hepatitis B vaccine and provide a brief review of other reported cases of lichenoid eruption seen following hepatitis B vaccination.

Adolescent↗

PubMedDate not supplied

Nonablative laser and light therapy: an approach to patient and device selection.

Nonablative laser and light therapy is a relatively novel modality for the improvement of the visual appearance of photodamaged, scarred, and injured skin. A number of different wavelengths and devices have been purported to be efficacious for the delivery of nonablative therapy. Among the features that can be addressed are red spots and telangiectasia, pigmentation and lentigines, and their daily routines while benefiting from the cumulative effects of skin rejuvenation.

Cosmetic Techniques↗

PubMedDate not supplied

Treatment of photoaging with topical aminolevulinic acid and light.

Photodynamic therapy (PDT) has been used for several years for the treatment of actinic keratoses and prevention of invasive nonmelanoma cancers. More recently, increasing physician expertise with the topical sensitizers and light sources employed in PDT has led to expanded applications, including its use for improvement of the visible signs of photoaging. Aesthetic treatment of photoaged skin with brief application of topical 5-aminolevulinic acid followed by well-tolerated light sources, such as intense pulsed light or pulsed-dye laser, can enhance the effectiveness of nonablative laser treatment without increasing adverse effects or downtime.

Administration, Topical↗

PubMedDate not supplied

Treatment of acne scarring.

Acne scarring is common but surprisingly difficult to treat. Scars can involve textural change in the superficial and deep dermis, and can also be associated with erythema, and less often, pigmentary change. In general, treatment of acne scarring is a multistep procedure. First, examination of the patient is necessary to classify the subtypes of scarring that are present. Then, the patient's primary concerns are elicited, and the patient is offered a menu of procedures that may address the various components of the scarring process. It is important to emphasize to the patient that acne scarring can be improved but never entirely reversed.

Acne Vulgaris↗