Biomedical subjects

M Akif Kilic

Publications and source records attributed to M Akif Kilic.

4 recordsLinked to original sources

PubMed2006

Malondialdehyde level and adenosine deaminase activity in nasal polyps.

OBJECTIVE: Although there are many reports on adenosine deaminase (ADA) activities in different tissues, no information is available about the enzyme activity in nasal mucosa and polyp tissues. Whereas ADA is related to the production of free radicals by neutrophils, malondialdehyde (MDA) is an indicator of lipid peroxidation that is a general mechanism of tissue damage by free radicals. This study is aimed at determining and comparing the ADA activity and MDA level in nasal polyps and normal mucosa. STUDY DESIGN AND SETTING: Twenty-three patients with nasal polyps and a control group consisting of 14 patients with septal deviation and lower turbinate hypertrophy were included in the study. Tissue MDA level was measured by the method of Okawa with modification and tissue ADA activity by the method of Giusti. RESULTS: In patients with nasal polyp, mean tissue MDA level and ADA activity were 2.43 +/- 0.38 nmol/mg protein (Pr) and 0.235 +/- 0.055 U/mg Pr, respectively, which were significantly higher than those of control nasal mucosa (1.03 +/- 0.41 nmol/mg protein and 0.056 +/- 0.011 U/mg Pr, respectively) (P < 0.05). In addition, tissue MDA level was positively correlated to ADA activity in nasal polyps (r = 0.701, P < 0.001). CONCLUSIONS: The present study showed the presence of detectable ADA activity in nasal mucosa, and also significant increases in both tissue MDA level and ADA activity in NP tissue when compared to normal turbinate tissue. EBM RATING: B-2b.

Adenosine Deaminase↗

PubMed2004

Prevalence of otitis media with effusion among primary school children in Kahramanmaras, in Turkey.

OBJECTIVE: The aim of this study was to determine the prevalence of otitis media with effusion (EOM) in primary school children. MATERIALS AND METHODS: Between March 2002 and April 2002, children attending primary schools in Kahramanmaras were screened. The schools were divided into two groups as urban and suburban. Also, a primary boarding school in the city was included in the study as a third group. A total of 2930 children between the ages of 6 and 16 years were included in the study. After otoscopic examination, tympanogram and acoustic reflex tests were carried out. Audiogram was performed if the child had a type B or a type C tympanogram. RESULTS: EOM was identified in 189 children, in 80 of whom EOM was unilateral and in 109 of whom was it bilateral. The overall prevalence of EOM was 6.5%, with a maximum prevalence of 10.4% at ages between 6 and 8 years. By increasing age, the prevalence of EOM decreased. Also, we found a higher prevalence rate of EOM in children attending primary boarding school (7.6%) than those attending other schools. CONCLUSIONS: The present study showed that living in crowded places like boarding school may have a role in the occurrence of OME. Also, our findings support the opinion that the age is one of the most important risk factors for OME. Our prevalence rates were different when compared with some other studies from Turkey and other countries. These different prevalence rates may be related to climatic and environmental factors as well as the methods used.

Adolescent↗

PubMed2003

Bacteraemia during tonsillectomy.

The aim of this study was to determine the incidence of bacteraemia during tonsillectomy and investigate the effect of the timing of culture sampling on the incidence of bacteraemia associated with it. Sixty-four consecutive patients who had been admitted for elective tonsillectomy were included in the study. Patients were randomly classified into two groups. Blood cultures as well as tonsillar surface and deep tissue cultures were obtained from all patients before tonsillectomy and 60 minutes after tonsillectomy. In addition, blood cultures were taken within two minutes following tonsillectomy for group 1 and 15 minutes after tonsillectomy for group 2. In group 1, the cultures obtained within two minutes were positive in nine patients, while only two of the blood cultures taken post-operatively were positive in group 2. The difference between the two groups was statistically significant (p < 0.05). The results of this study suggest that a transient bacteraemia occurs frequently in association with tonsillectomy, but the timing of culture sampling for its detection is important.

Adolescent↗

PubMedDate not supplied

Outcome of surgery for crooked nose: an objective method of evaluation.

OBJECTIVES: The aim of this study was to report the authors' surgical results, and to present their method of angle measurement using the Scion Image computer program to evaluate surgical results for crooked noses. METHODS: The study included 27 patients with crooked noses: classified as C-type and 14 classified as I-type. Deviation angles were measured by using the Scion Image computer program on frontal views before and at least 3 months after the operation. Correction of the crooked nose was performed through an open approach with the patients under general anesthesia. RESULTS: Significant correction was achieved for both types of crooked noses (p <0.05). The results for the I-type crooked noses were closer to the ideal angles than those for the C-type, but the difference was not significant. The findings showed that 66.7% of the patients with crooked noses, had good or excellent results after surgery: 53.8% of those with the C-Type and 78.6% of those with the I-type. CONCLUSION: It is difficult to achieve satisfactory results in the correction of crooked noses. The angle measurement method using the Scion Image computer program may be helpful in evaluating the effectiveness of different surgical techniques.

Adolescent↗