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Biomedical subjects

M Akao

Publications and source records attributed to M Akao.

At least 109 records · Page 6Linked to original sources
PubMed1977

Inhibitory effect of fumaric acid and dicarboxylic acids on gastric ulceration in rats.

Production of gastric ulcerations in rats by pyloric ligation was found to be inhibited by either intraperitoneal or oral administration of fumaric acid in a dose of 50 mg per kg. The antiulcer action was also exhibited by the four-carbon dicarboxylic acids, maleic acid, oxalacetic acid, succinic acid and malic acid. The studies on fumaric acid indicated that the acid's antiulcer action was based on its ability to inhibit the gastric juice secretion and to dilate the stomach muscle.

Animals↗
PubMed1976

Inhibitory effect of Capsella bursa-pastoris extract on growth of Ehrlich solid tumor in mice.

The treatment of ICR mice with i.p. injections (0.14 g/kg/day) of the extract of Capsella bursa-pastoris herb (Cruciferae) caused 50 to 80% inhibition of the solid growth of Ehrlich tumor cells that had been inoculated into the s.c. tissue of the animals. The tumor lumps in the treated mice showed multifocal necroses and the infiltartion of host fibrous tissue cells. Experiments were also performed to isolate and identify the active component for the antitumor action, and an acidic substance was isolated in crystalline form from the herb extract. This acidic substance was identified as fumaric acid and was effective in inhibiting the growth of Ehrlich solid tumor at a dose of 10 mg/kg/day. The 50% lethal dose (i.p.) of this acid was 266 mg/kg.

Animals↗