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Biomedical subjects

M Aimetti

Publications and source records attributed to M Aimetti.

16 recordsLinked to original sources
PubMed2005

Treatment of wide, shallow, and predominantly 1-wall intrabony defects with a bioabsorbable membrane: a randomized controlled clinical trial.

BACKGROUND: The regenerative therapy of non-contained intrabony defects achieves better results when bioabsorbable membranes are combined with a filling material. The purpose of the present study was to analyze clinical and radiographic effectiveness of a space-making bioabsorbable membrane in the treatment of wide and shallow intrabony defects characterized by a relevant 1-wall component. METHODS: Eighteen pairs of angular bone defects were selected in 18 healthy, non-smoking patients (age range 30 to 66 years). Prior to the surgical phase, patients were enrolled in a strict periodontal program including oral hygiene instructions and scaling and root planing (presurgical full-mouth plaque score <10%). Using a split-mouth design, 18 sites were randomly assigned to receive guided tissue regeneration (GTR) using a bioabsorbable membrane (test group) and 18 to receive open flap debridement alone (control group). Clinical treatment outcome was evaluated 12 months postoperatively for changes in probing depth (PD), clinical attachment level (CAL), and position of gingival margin (REC) and radiographically for bone changes. RESULTS: Open flap debridement and GTR yielded statistically significant (P<0.0001) PD reduction (2.39+/- 0.92 mm and 3.44+/- 0.78 mm), CAL gain (1.50+/- 0.99 mm and 2.89 +/- 0.90 mm), increased REC (-0.89 +/- 0.58 mm and -0.56 +/- 0.92 mm) and bone fill (1.05+/- 0.94 mm and 2.13+/- 1.21 mm) when 12-month data were compared to baseline. The differences between test and control groups were statistically significant for all parameters (P<0.007) except for REC (P=0.25). CONCLUSION: The use of this bioabsorbable membrane would seem to be effective in the treatment of intrabony defects with unfavorable architecture without the use of filling materials.

Absorbable Implants↗
PubMed2005

Non-surgical periodontal therapy of cyclosporin A gingival overgrowth in organ transplant patients. Clinical results at 12 months.

AIM: The aim of the present study was to evaluate the clinical effects of non-surgical and supportive periodontal treatment on cyclosporin A-induced (CsA) gingival overgrowth (GO) in a group of transplant patients. METHODS: Thirty patients received etiological periodontal treatment and were placed in a -two-monthly recall program for 12 months. Plaque index, bleeding index, probing depth, degree of GO using the Seymour index (hypertrophy index, HI) and distance between the mucogingival junction and the base and the apex of each interdental papilla were recorded at baseline and repeated 12 months after treatment. RESULTS: At baseline, 22 patients had HI values >30% and were considered as ''responders''. A total of 376 gingival units (72.31%) in the anterior segments and 376 (54.97%) in the posterior ones presented GO with a mean HI value of 2.22 +/- 1.95 and 1.24 +/- 1.57, respectively. The etiological treatment resulted in a statistically significant improvement of all parameters assessed (P<0.0001). All patients had a decrease in the number of affected sites (mean HI values of 0.42 +/- 0.77 and 0.39 +/- 0.85 in the anterior and posterior segments) and none had HI values >30% and any gingival unit with score of 5 at the end of the observation period. CONCLUSIONS: Detailed instructions and intense motivation to oral home hygiene measures, inserted in an etiological treatment and a two-monthly maintenance therapy, appear to be effective in controlling the GO and in maintaining clinical improvements for prolonged time period.

Adult↗
PubMed2005

Treatment of mandibular class II furcation defects by the use of amelogenins and autologous bone. Two case reports.

The aim of this preliminary study was to evaluate the clinical effectiveness of the association of amelogenins and autologous bone graft in the management of mandibular class II furcation defects. This randomized case-controlled study was conducted on 2 patients who presented 2 contralateral mandibular buccal class II furcation lesions. One defect was treated by amelogenins and autologous bone graft (test site) and the other one by open flap debridement (control site). At baseline and at 12 months postoperatively, the full-mouth plaque score (FMPS) and the full-mouth bleeding score (FMBS), the probing depth (PD), the clinical attachment level (CAL) and the recession (REC) were recorded and a periapical radiograph of the selected area was taken. In addition, at 12 months a surgical re-entry was performed. Test sites had a greater horizontal PD reduction and radiographic bone filling compared to control sites. None of the treated sites achieved complete furcation closure. At the time of re-entry, furcations treated by amelogenins were partially filled by newly formed not soundable hard tissue, while furcations treated by conventional flap surgery were filled by epithelial and connective tissue. These findings suggest that the treatment of mandibular class II furcations by amelogenins and autologous bone graft may result in a significant clinical improvement. Further long-term studies conducted on a larger sample size are therefore needed to confirm our results.

Amelogenin↗
PubMed2004

Debridement and local application of tetracycline-loaded fibres in the management of persistent periodontitis: results after 12 months.

BACKGROUNDS/AIMS: The aim of our study was to evaluate the clinical, radiological and microbiological response to the local delivery of tetracycline (TE) of sites with persistent periodontal lesions. MATERIALS AND METHODS: The study was conducted in a split-mouth design. Nineteen patients with at least four bilateral pockets 4-5 mm and bleeding on probing (BOP) were treated with scaling and root planing (SRP) plus TE fibres (test sites) or with SRP alone (control sites). Clinical and radiological measurements were taken at baseline, 6 months and 12 months post-operatively. Subgingival plaque samples were collected at baseline, at fibres removal, 6 and 12 months following treatment and analysed by polymerase chain reaction. RESULTS: Both treatments yielded a statistically significant (p<0.05) reduction of probing depth (2.05 and 1.21 mm), gain of clinical attachment level (1.71 and 0.53 mm) and reduction of BOP scores (23.68% and 57.89%) for TE and SRP groups, respectively, when comparing 12-month data with baseline. The differences between two groups were significant. The prevalence of Treponema denticola and Bacteroides forsythus decreased after therapy in both groups but only in the test sites Actinobacillus actinomycetemcomitans and Prevotella intermedia were not yield detected. The pathogens could be eliminated from five periodontal pockets by SRP alone, while 21 TE sites were not recolonized at 12 months. CONCLUSIONS: SRP plus TE fibres gave the greatest advantage in the treatment of periodontal persistent lesions at least 12 months following treatment.

Aggregatibacter actinomycetemcomitans↗
PubMed2003

Molecular approaches to the identification and treatment monitoring of periodontal pathogens.

Two different PCR-based molecular approaches, a commercial kit for detection of A. actinomycetemcomitans, P. gingivalis, P. intermedia, B. forsythus and T. denticola (Amplimedical "Paradonthosis") and a home-made multiplex PCR for A. actinomycetemcomitans, P. gingivalis and B. forsythus were compared for monitoring the efficacy of different dental treatments on localized persistent periodontal pockets. 44 sites were randomized in two treatment groups: mechanical treatment (22 control sites) and in conjunction with the application of tetracycline fibres (22 experimental sites). 40/44 sites were found positive with both tests for A. actinomycetemcomitans, P. gingivalis and B. forsythus pretheraphy. P. intermedia was detected alone in only three sites during the follow-up, while T. denticola. was always associated with the other pathogens. 20 sites were positive in conventional cultures for one to three of the pathogens. PCR-based approaches provided a sensitive and reliable method for identification and monitoring treatment of periodontal pathogens.

Actinobacillus Infections↗
PubMed2001

MET receptor is overexpressed but not mutated in oral squamous cell carcinomas.

Oral squamous cell carcinoma (SCC) is a neoplasm characterized by a high degree of local invasion and an elevated rate of metastasis to cervical lymph nodes. It has been shown that the Hepatocyte Growth Factor/Scatter Factor Receptor Met is constitutively activated in many human tumors of epithelial origin and that it plays a critical role to confer invasive properties to neoplastic cells. Most frequently, Met activation is due to receptor overexpression, but also point mutations in the tyrosine kinase domain can lead to deregulated activation. Here we show that in all the primary tumors examined this receptor is overexpressed. Direct sequencing of Met mRNAs failed to find any activating mutation in its intracellular domain. Moreover, in cell lines derived from squamous cell carcinomas, HGF-induced activation of Met resulted in the acquisition of invasive properties. All together these data suggest that the MET oncogene is involved in progression of squamous cell carcinoma toward an invasive-metastatic behavior.

Adult↗
PubMed2001

Maxillary sinus elevation: the effect of macrolacerations and microlacerations of the sinus membrane as determined by endoscopy.

The authors evaluated the health of the maxillary sinus in a group of 18 patients who had undergone sinus lift surgery for implantation purposes, using computed tomography and endoscopic imaging as a means of diagnosis. The study was performed after a mean interval of 31 months. All sinus lift operations were carried out using the lateral flap technique. The authors evaluated graft characteristics and intraoperative and postoperative complications and compared the results with computed tomography and endoscopic images. Endoscopy of a maxillary sinus that underwent microlaceration of the mucosa during sinus lifting showed a situation compatible with healthy conditions. In cases complicated by macrolaceration, the endoscopic picture was typical of sinusitis, even where clinical conditions of this type were not present. In the absence of intraoperative complications, the endoscopic appearance of sinus mucosa appears to improve when autologous graft material is used.

Adult↗
PubMed1999

[Effect of immobilization after treatment of mandibular fractures].

BACKGROUND AND AIM: The aim of this study was to assess whether the duration of intermaxillary block in patients with non-condylar mandibular fractures can interfere with restored mandibular function and whether there is a statistically significant correlation between the duration of joint immobilisation and the onset of temporo-mandibular joint pathologies. METHODS: A clinical evaluation was made of 40 patients treated for non-condylar mandibular fractures during the period 1991-1992. The patients were subdivided into two groups depending on the type of treatment and the duration of the intermaxillary block. Group A included patients treated with intermaxillary block alone lasting more than 25 days. Group B included patients treated surgically with intrafocal osteosynthesis with immobilisation lasting less than 15 days. RESULTS: The follow-up of results (3.7 years) showed a maximum mean aperture in Group A of 45.1 mm compared to 50.1 mm in Group B. The mean score for mandibular clinical dysfunction in patients in Group A was 5.0 points (SD +/- 4.75), whereas it was 0.7 points (SD +/- 1.45) in patients in Group B. This difference between the two groups was statistically significant (p < 0.01). CONCLUSIONS: The results of this study suggest that jaw immobilisation in mandibular fractures may be potentially damaging for the temporo-mandibular joint, sometimes leading to painful dysfunctional syndromes. For this reason, even in the case of mandibular fractures without decomposition, the authors feel that it is advisable to avoid long periods of immobilisation in patients with a positive history of mandibular dysfunction.

Fracture Fixation↗
PubMed1999

[Odontogenic kertocysts. Review of a series of cases and long-term clinical control].

BACKGROUND AND AIMS: The aim of this retrospective study was to identify and evaluate the clinical characteristics and incidence of recidivation in a series of 40 cases of keratocyst consisting of 31 primary lesions, 7 cases of primary recidivation (17.5%) and 2 cases of secondary recidivation (5%). All the lesions were large sized and were treated using surgery. All patients underwent an annual clinical control for a minimum follow-up of seven years. METHODS: The authors present a series of 40 odontogenic keratocysts treated between 1985 and 1996 by the Division of Maxillofacial Surgery at Turin University. The series consisted of 40 keratocysts including 31 primary lesions, 7 cases of primary recidivation (17.5%) and 2 cases of secondary recidivation (5%); 12 patients were female (38.7%) and 19 were male (61.3%). The mean age of patients was 42 years old. The clinical records and enclosed X-ray documentation (OPT X-ray, head X-ray, face X-ray) were examined for each patient, together with histological findings. Each case then underwent an annual follow-up. RESULTS: The review of clinical data and the examination of X-ray documentation showed that 28 lesions developed in the mandible and only 3 cases in the upper jaw. From a therapeutic point of view, keratocysts localised in a mandibular site were managed using cystectomy in 19 cases and in 18 cases this was followed by marsupialisation. Caldwell-Luc's operation was used in 2 cases of intrasinusal maxillary development, whereas the single case of extrasinusal development underwent cystectomy. Recidivation always involved the mandible and occurred in 22% of cases within 5 years of surgery. Of the 19 cases undergoing simple cystectomy, 8 cases (42%) revealed recidivation. Only one (5.5%) of 18 cases treated using cystectomy and marsupialisation showed recurrence. CONCLUSIONS: On the basis of their experience and in view of the specific characteristics of keratocysts, in particular the tendency to undergo recidivation, the authors affirm that annual clinical and radiological controls are indispensable and important, including biopsy where necessary, in order to diagnose new lesions promptly irrespective of the surgical technique used.

Adolescent↗
PubMed1998

[The Caldwell-Luc procedure in the management of maxillary sinusitis. Long-term results].

BACKGROUND: The surgical technique proposed by Caldwell and Luc more than a century ago has been applied in over a million cases to treat maxillary sinusitis. A critical re-evaluation of the method has been in progress for several years, in the light of the results that can be achieved with endoscopic functional surgery. METHODS: In a retrospective study, operations performed according to the Caldwell-Luc technique on 40 patients, mean age 45 years, between 1992 and 1996, were evaluated critically to determine the efficacy of this approach in treating maxillary sinusitis, with particular emphasis on the incidence of immediate or delayed complications. Initially, clinical and radiological data concerning each patient where considered with particular reference to the subjective and objective symptomatology, preoperative radiological diagnosis and etiology of the sinusitis. RESULTS: Having completed the analysis of the documentation available, some of the patients were recalled and subjected to an in-depth instrumental diagnosis through traditional and CT radiography. CONCLUSIONS: It was concluded that, in consideration of the marked incidence of complications, the Caldwell-Luc procedure may be defined as a non-obligatory therapeutic option even in chronic maxillary sinusitis. The use of this surgical procedure is rational in cases of antral tumour, trauma, very serious mycotic or septic factors, or when a surgical approach to the pterigo-maxillary fossa is necessary. In all other cases, the preferred treatment must now be endoscopy.

Adult↗
PubMed1998

[Sinusoscopy in stomatology. Review of a 5-year clinical experience].

BACKGROUND: Investigative sinus endoscopy for purely diagnostic purposes has become an important therapeutic tool for disorders of the paranasal system thanks to the enormous technological developments of the last twenty years. METHODS: In a retrospective study, sinus endoscopies carried out between 1990 and 1994 on 57 patients, mean age 43 years, were subjected to critical re-evaluation, with the aim of evaluating the efficacy of endoscopic treatment. In the first phase, the documentation available for each patient was examined; it included clinical data, preoperative traditional and CT radiographs, rhinoscopic and sinus endoscopic findings. Once the analysis of the available documentation had been completed the patients were recalled and subjected to clinical and radiological evaluation. Radiographic examination was carried out by traditional radiography. RESULTS: CT scanning was only performed for those patients in whom the clinical findings indicated a possible relapse. Immediate and delayed complications occurring after the endoscopic sinus surgery were taken into consideration. CONCLUSIONS: In conclusion, sinus endoscopy is a fundamental instrumental investigation in the diagnosis of rhinosinusopathies. It can no longer be considered as only a diagnostic investigation able to provide clear visual images, it also allows specimens to be taken for bacteriological, micological, cytological and histological analysis. Furthermore, endoscopic surgery can treat pathologies for which, until a few years ago, operations were necessary which respected the physiology of the paranasal system to a much lesser extent (Denker-Caldwell-Luc).

Endoscopy↗
PubMed1997

[Mandibular cysts treated by decompression].

The authors reports a case of mandibular keratocystis treated using decompressive therapy and subsequent cystectomy after subtotal reduction of the cystic lacuna. The bone regenerative process was probably aided by the young age of the patient.

Adolescent↗
PubMed1989

[Polyamines in tumors of the oral cavity].

The polyamines putrescine, spermidine and spermine are essential for normal growth and differentiation and the activity of the enzymes participating in their synthesis and catabolism are markedly modified in actively proliferating cells in vitro and in vivo. In some neoplastic cells a good correlation is observed between polyamine concentration and histology, so that a potential usefulness as diagnostic and prognostic markers has been suggested. In the study of ornithine decarboxylase, S-adenosylmethionine decarboxylase and spermidine acetyltransferase activities and of polyamine concentration in tumors of the oral cavity we have shown a marked increase in the tumor cells. In the epulis the ratio spermidine/spermine is inverted, so that it could be useful in differentiating benign from malign tumors.

Adenosylmethionine Decarboxylase↗
PubMed1989

[Apicoectomy: comparison between 2 case series].

Data on 2 series of apicectomies performed in 1966-69 and 1978-82 respectively are compared. The comparison was based on clinical assessments and radiographic findings in patients given a repeated check-up a later date. Similar results were obtained in the two series, confirming the importance of scrupulous pre-operative endodontic treatment combined with the use of non-absorbable canal material. It is felt that this, combined with a scrupulously precise periapical surgical technique will ensure total success in all cases.

Apicoectomy↗
PubMedDate not supplied

Debridement and local application of tetracycline in the management of persistent periodontitis. Clinical and microbiological results after 12 months.

AIM: The purpose of this study was to evaluate the clinical and microbiological efficacy of local delivery of tetracycline in persistent periodontal lesions after topical therapy. METHODS: A total of 44 bilateral pockets 4-5 mm deep and bleeding on probing were selected in 11 non-smokers patients, 22 treated by scaling and root planing plus tetracycline fibres (test sites) and 22 with scaling and root planing alone (control sites) in a split-mouth design. Bleeding on probing, probing depth and clinical attachment level were recorded at baseline, 6 and 12 months postoperatively. The prevalence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus and Treponema denticola was monitored by PCR at baseline, fibres removal, 6 and 12 months following treatment. RESULTS: The improvements in clinical parameters were greater in the tetracycline than in the control group. The reduction of bleeding on probing scores was 86.4% and 40.9%, the decrease of probing depth was 2.25 mm and 1.19 mm and the gain of clinical attachment level was 2.04 mm and 0.64 mm for test and control groups, respectively, over the 12-month period. The adjunctive use of tetracycline consistently resulted in a lower percentages of sites with detectable levels of A. actinomycetemcomitans, P. intermedia and P. gingivalis, while no differences were detected between treatments in the prevalence of T. denticola and B. forsythus. The pathogens could be eliminated from 3 periodontal pockets by debridement alone and from 12 sites by tetracycline at 12 months. CONCLUSIONS: Tetracycline local delivery gave the greatest advantage in the long-term treatment of periodontal persistent lesions.

Administration, Topical↗