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M Adesnik

Publications and source records attributed to M Adesnik.

76 records · Page 5Linked to original sources
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Brain cytochromes P-450 are responsive to phenobarbital and tricyclic amines.

Cytochrome P-450 form b has been detected for the first time in rat brain by cross-hybridization of poly(A+) RNA with a radiolabelled cDNA probe. The cross-hybridizable material was easily detectable in rats after treatment with phenobarbital but not in untreated rats. Moreover, treatment of rats with amitriptyline or imipramine, tricyclic antidepressants in wide therapeutic use for depression, markedly increases the amount of RNA species hybridizing with P-450b cDNA probe in comparison to untreated controls. These observations raise the issue of a possible role for brain cytochromes P-450 in the metabolism of drugs such as the tricyclic antidepressants.

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The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci.

In this update we provide a list of the 71 P450 genes and the four P450 pseudogenes that have been characterized as of September 30, 1988. The chromosomal locations of many of these genes are also summarized. A modest revision of the initially proposed nomenclature of the P450 superfamily (Nebert et al., DNA 6, 1-11, 1987) is described specifically for the human and mouse chromosomal loci. The motivation for this revision is to conform to the rules of nomenclature for human and mouse genes. Recommendations for the naming of chromosomal loci include the root symbol "CYP" for human ("Cyp" for mouse), denoting "cytochrome P450." We recommend that this root also be used for other organisms. For a chromosomal locus, the root symbol is followed by an Arabic numeral designating the P450 family, a letter indicating the subfamily, and an Arabic numeral representing the individual gene within the family or subfamily. Numbers of the individual genes usually will be assigned in the order the genes are identified. This system is consistent with our earlier proposed nomenclature for P450 families and gene products from all eukaryotes and prokaryotes.

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