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M Adamec

Publications and source records attributed to M Adamec.

70 records · Page 4Linked to original sources
PubMed1992

The natural history of lung cancer estimated from the results of a randomized trial of screening.

The results from a randomized controlled trial of screening for lung cancer in Czechoslovakia have been used to estimate parameters of the natural history, using a model to simulate the disease process and the effects of screening. The results suggest that the period before clinical presentation during which lesions can be detected by screening is very short (seven to eight months). This implies that to detect three-quarters of all lung cancers by screening, two examinations per year are necessary, and that such a program would advance diagnosis by six months if there were complete participation. The results of the trial itself suggest that the benefit, in terms of a reduction in mortality from lung cancer, is likely to be very small.

Adult↗
PubMed1991

[Evaluation of epidemiologic studies using the EPI INFO program].

The authors describe the EPI INFO system suitable for introducing on a personal computer, compatible with the standard IBM XT/AT. The system was elaborated by a group of workers from Centres of Disease Control in Alabama in 1988. The advantage of the system is in addition to ready availability (it is distributed on a non-commercial basis), in particular because it combines the advantages of the data base and statistical programme system. It makes it possible storage of data, their easy processing by classification and tabulation, evaluation by some statistical (parametric and non-parametric) tests and simple graphical presentation of results, e.g. in histograms or figures using columns. Moreover, it is possible to make in the EPI INFO system further modifications of the stored data and to combine groups of similar or different format. The system does not only create its own external data groups but makes also possible their conversion into other systems and conversely is able to create from external groups of data its own groups of data.

Epidemiologic Methods↗
PubMed1990

Lack of benefit from semi-annual screening for cancer of the lung: follow-up report of a randomized controlled trial on a population of high-risk males in Czechoslovakia.

Cigarette-smoking males (6,364), aged 40-64, were randomized into an intervention group which received 6-monthly screening by chest X-ray and sputum cytology, and a control group which received no asymptomatic investigation. After 3 years, both groups entered a follow-up period during which they received annual chest X-rays. Lung cancer cases detected by screening were identified at an earlier stage, more often resectable, and had a significantly better survival than "interval" cases diagnosed mainly because of symptoms. Comparison of the 2 groups showed a higher incidence of lung cancer in the intervention group, despite the follow-up period when both groups received annual examinations. There was no significant difference in mortality between the 2 groups.

Adult↗
PubMed1990

[Supravalvular aortic stenosis].

The authors describe the case of an inborn supravalvular aortal stenosis in an adult patient who was successfully treated by a plastic operation of the stenotic portion of the ascendent aorta by means of a synthetic patch. At the same time also a plastic operation of an incompetent mitral valve was made.

Adult↗
PubMed1989

[The occurrence of circadian rhythm in respiration in healthy persons and in patients with bronchial asthma].

The authors examined in 69 healthy young men at times 0, 3, 6, 9, 12, 15, 18 and 21 hours values of FVC, FEV1, FEF50 a PEF. In 149 patients with bronchial asthma after the same time intervals FEV1 was assessed, whereby the interval at 3 a.m. was used as the mean of values at times 0 and 6 a.m. By analysis of variance the minima of the majority of investigated indicators were assessed in healthy subjects at 3 a.m. and 9 a.m. By cosinor analysis a statistically insignificant circadian rhythm for values FEC and FEV1 was proved in the entire group of healthy subjects and in subgroups of smokers and non-smokers. No rhythm was found in values of FEF50 and PEF. Rhythms in the ventilation values were detected in 40-60% of the subjects, in the remainder no rhythms were detected. In patients with bronchial asthma a significant circadian rhythm of FEV1 changes was found in groups with a morning or variable type of respiration. In groups with a stabilized ventilation a rhythm was detected but was not significant. In the group with an apparently irreversible obstruction no circadian rhythm was found.

Adolescent↗
PubMed1989

[Inflammatory aneurysm of the pelvic artery].

The authors describe an uncommon case of an inflammatory aneurysm of the common abdominal aorta which was successfully treated by resection and prosthesis. In the discussion the authors deal with the specific features of this type of aneurysm, as compared with common sclerotic ones. They recommend the best diagnostic procedure, surgical approach and postoperative treatment.

Adult↗
PubMed1983

Importance of mathematical models and multivariant statistical analysis for the diagnosis of ventilation disorders.

The authors present results of a comprehensive, mostly mathematical, solution of problems of the mechanism of breathing and ventilation. The need for a multivariant approach is based on the knowledge of disorders of the individual factors influencing ventilation. The authors are convinced that this approach means a useful contribution to the establishment of diagnosis and to economization of treatment.

Adult↗
PubMedDate not supplied

Simulation of human reactions under extreme conditions.

Lung mass determination in cooperative subjects is possible by computation from the "flow-volume" loop, if total lung resistance (Raw) is known. The model is applicable to tracking changes in weightlessness. Modifications for improving the result are discussed.

Elasticity↗
PubMedDate not supplied

Tacrolimus compared with cyclosporine microemulsion in primary simultaneous pancreas-kidney transplantation: the EURO-SPK 3-year results.

UNLABELLED: This 3-year study compared tacrolimus versus cyclosporine (CsA) microemulsion (ME) in conjunction with rATG induction, mycophenolate mofetil (MMF) and short-term corticosteroids in primary simultaneous pancreas-kidney (SPK) transplantation. PATIENTS AND METHODS: This large, prospective, multicenter study was conducted in 10 European centers and one center in Israel. Of the 205 SPK transplants performed from 1998 to 2000, 103 patients were randomly assigned to tacrolimus and 102 to CsA ME. All patients received concomitant rATG induction therapy, MMF, and short-term corticosteroids. RESULTS: In total, 36.9% patients receiving tacrolimus and 57.8% receiving CsA ME discontinued treatment (P = .003). Although 3-year patient and kidney graft survival rates were similar in both groups, pancreas survival was superior with tacrolimus (89.2% versus 72.4%; P = .002). Thrombosis resulted in pancreatic allograft loss in 10 patients receiving CsA ME and in 2 treated with tacrolimus (P = .02). The first episode of biopsy-proven rejection was moderate or severe in 1 of 31 tacrolimus-treated patients and 11 of 39 patients receiving CsA ME (P = .009). Overall adverse event frequency was similar in both groups, but surgical events were lower in the tacrolimus treated group. CONCLUSION: Tacrolimus was more effective than CsA-ME to prevent moderate or severe kidney or pancreas rejection after SPK transplantation. It also provided superior pancreatic graft survival and reduced the risk of pancreas thrombosis.

Adrenal Cortex Hormones↗
PubMedDate not supplied

Beneficial effect of pancreas and kidney transplantation on advanced diabetic retinopathy.

In pancreas recipients with advanced diabetic eye disease, conflicting ophthalmologic results over different follow-up periods have been reported. In the present prospective study we performed ophthalmologic evaluation groups of type I diabetic patients: 1) normoglycemic recipients of pancreas and kidney grafts (group SPK, n = 43, follow-up 44.9 +/- 35.1 months), 2) pancreas and kidney graft recipients with nonfunctioning pancreatic graft, and recipients of isolated kidney graft (group K, n = 45, follow-up 60.3 +/- 34.2 months). The examinations were performed before transplantation, at the end of follow-up (at least 1 year), and in 63 recipients also at 3 years posttransplant. Visual acuity results at baseline and at the end of follow-up were 0.48 +/- 0.39 vs. 0.50 +/- 0.39 in the SPK group, and 0.46 +/- 0.38 vs. 0.40 +/- 0.39 in the K group. While intragroup changes were not significant, the changes were significantly different between the groups (p < 0.05). Fundoscopic findings at the end of follow-up were improved, stabilized, or deteriorated in the SPK group in 21.3%, 61.7%, and 17.0%, respectively. The respective figures for the K group were 6.1%, 48.8%, and 45.1% (p < 0.001). Similar results were obtained when evaluating findings at 3 years posttransplant. Before transplantation, 78% of the SPK group and 81% of the K group had been treated by laser. The need for additional posttransplant laser therapy was significantly lower in the SPK (31%) than in the K group (58%; p < 0.001). In conclusion, pancreas transplant exerts a beneficial effect on the course of diabetic retinopathy even in its late stage.

Adult↗