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Biomedical subjects

M Abramson

Publications and source records attributed to M Abramson.

132 records · Page 8Linked to original sources
PubMedDate not supplied

Bullous myringitis with sensorineural hearing loss.

Bullous myringitis is manifested by moderately severe otalgia associated with vesicles on the tympanic membrane and medial external auditory canal wall. This disease occurs mainly in young adults, most commonly in winter, and is usually preceded or accompanied by an upper respiratory infection. A reversible sensorineural loss developed in three of 22 patients. Complement fixation antibody studies performed on ten patients failed to implicate Mycoplasma pneumoniae, influenza virus types A or B, or adenovirus as the causal agent.

Adolescent↗
PubMedDate not supplied

Collagenase and protease activities in head and neck tumors.

An analysis of specimens of 43 head and neck tumors revealed that collagenase and protease activities paralleled each other and varied according to the anatomic site; highest activities were in tongues and tonsils, which are known to have low five-year survival rates. The greatest differences in both enzyme activities were observed in the studies of histologic patterns and tumor differentiation. The ulcerated tumors with inflammatory infiltrates having high enzyme activities suggest that collagenase and protease may be derived from inflammatory cells.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Pathogenic factors in bone resorption in cholesteatoma.

Factors present in skin appear to enhance bone resorption in chronic otitis media. These skin factors were replicated in a series of experiments using an animal model. The presence of activated granulation tissue is a universal finding in bone resorption in otitis media. Skin promotes bone resorbing connective tissue by the action of keratin as a foreign body, by the enhancement of middle ear sepsis, by stimulation and activation of inflammatory cells and most importantly through the creation of pressure.

Animals↗
PubMedDate not supplied

The effect of fibronectin on the migration of keratinocytes.

Basal cell migration appears to be a crucial factor in the development of acquired cholesteatoma. We studied the effect of fibronectin (FN) on the migration of basal cells. Keratinocytes were prepared from epidermis of newborn rats and fractionated using Percoll gradients. The lightest cells were maturing keratinocytes and the heaviest, basal cells. The effect of various concentrations of FN on keratinocyte migration was studied using Boyden's chamber assay and the spreading assay methods. FN had little effect on mature keratinocytes, but FN markedly stimulated the migration of keratinocyte basal cells. FN appears to play an important role in stimulating basal cell keratinocyte migration.

Animals↗