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Biomedical subjects

M Abbes

Publications and source records attributed to M Abbes.

At least 37 records · Page 2Linked to original sources

[Our experience in the use of epidermal cell cultures in the reconstructive surgery].

The plastic surgery team of the Antoine-Lacassagne cancer center (Nice, France) presents the results of 18 grafts (13 patients) of epidermal cells grown in culture. Cell culture techniques and histologic features are analyzed. The possibilities of this method are discussed on the basis of study results and comparison with other publications on the repair of cutaneous wounds other than burns. The favorable rate of successful grafts (50%) and the indications for the technique are discussed. Used as a complementary procedure, epidermal cell grafts permit better quality scarring, comparable to that obtained with thin skin grafts. In addition, disfiguration of donor sites is eliminated.

Adult↗

Gracilis blood supply: anatomical and clinical re-evaluation.

In a review of 20 gracilis flaps in 18 patients, variations in flap viability have been found. In response to these findings, a detailed anatomical study was performed in 15 fresh cadavers. Selective dye injections evaluated the limits of the skin paddle depending on the dominant pedicle. Most of the musculocutaneous perforators were in the upper two-thirds of the gracilis. In one selected application the main blood supply to the skin was recognised to be proximal. Despite the variations in viability, the flap proved to be a versatile and totally adequate tool.

Adult↗

[Our experience with the use of epidermal cell cultures in reconstructive surgery].

The plastic surgery team of the Antoine-Lacassagne cancer center (Nice, France) presents the results of 18 grafts (13 patients) of epidermal cells grown in culture. Cell culture techniques and histologic features are analyzed. The possibilities of this method are discussed on the basis of study results and comparison with other publications on the repair of cutaneous wounds other than burns. The favorable rate of successful grafts (50%) and the indications for the technique are discussed. Used as a complementary procedure, epidermal cell grafts permit better quality scarring, comparable to that obtained with thin skin grafts. In addition, disfiguration of donor sites is eliminated.

Adult↗

[Autograft procedures in reparative cancer surgery of the loss of substance of the nose. Critical study].

Using several examples, the authors analyse the choice of reconstructive methods available after excision of cutaneous tumours of the nose. Although a variety of procedures exist, one or two specific flap procedures may be preferred in terms of their safety and cosmetic result. Before describing these procedures, the authors briefly review the basis of surgical treatment in the particular case of the nasal region.

Adult↗

[Repair of chest wall defects after full thickness surgical resection].

The authors discuss the development of their approach to the repair of full-thickness chest wall resection based on a series of twenty-two patients operated between 1967 and 1989. The defect resulting from resection of all tissue planes, either for breast in situ, recurrences, radiation lesions or primary tumours, raises difficult problems. Mammary or cutaneous autoplasties, performed during the early years, have become less frequent, essentially because of the development of musculo-cutaneous flaps (pectoralis major, rectus abdominis, latissimus dorsi) which provide global anatomical and functional repair. The greater omentum island flap, used since 1974, still occupies an important place because of its plastic and trophic qualities in irradiated regions. When chest wall rigidity is compromised, Mersilene patch remains the material of choice. The quality of the results obtained in terms of comfort justifies the use of this major surgery which is now well defined.

Adult↗

[Treatment of cancer of the anal canal with combination radiochemotherapy: apropos of 12 cases].

We present 12 patients (3 male, 9 female) aged from 53-88 years with squamous cell cancer of the anal canal treated with combined radiotherapy-chemotherapy (5 FU-mitomycin C); the distribution of the tumours was 2 T4, 6 T3, 3 T2, 1 T1). In 11 patients evaluated, complete remission was obtained in 8 with partial remission in 2 others. In spite of this good result with combined treatment, 4 patients had a recurrence between 9 and 26 months. Five patients survived and 2 died without disease (16-38 month), 3 patients died and one survived with disease. The small series confirms the efficacy of this combination which treated bulky tumours (T3-T4). It is necessary however to compare these results with radiation alone in a randomised trial.

Aged↗

Factors affecting relapse in node-negative breast cancer. A multivariate analysis including the labeling index.

Between 1975 and 1982, 167 patients with carcinoma of the breast without axillary lymph node metastases were studied. The thymidine labeling index (LI), representing the percentage of cells in the DNA synthesis phase, was measured in all these patients. High LI values were more frequently encountered in young patients (P = 0.05), in low estrogen receptor (ER) tumor content (P = 0.007) and in high grade tumors (P = 0.0002). The overall 8-year relapse-free survival (RFS) was 68%. Univariate analysis demonstrated that RFS was influenced by histological grading (P = 0.03), ER (P = 0.03), PR (P = 0.02) and LI (P = 0.01). Multivariate analysis using the Cox regression model selected the LI as the single significant prognostic factor with regard to RFS (P = 0.037). These results emphasize the important role of cell proliferation kinetics in defining node-negative breast cancer patients with a high risk of relapse.

Adult↗

Practical importance of breast microcalcifications: report on 112 cases.

The authors discuss the results of a diagnostic and therapeutic study of 112 cases of breast microcalcifications with no palpable lesions. The criteria in favor of obtaining a surgical specimen are discussed as a function of population characteristics and a review of the literature. Techniques for the localization of these lesions are defined. Decisions as to the necessity for ulterior treatment of the breast are based on certain criteria, and above all on the risk of evolution of invasive lesions with nodal involvement. The high quality of current mammograms has considerably increased the number of patients referred for biopsy. In the case of microcalcifications masking malignant lesions, the advances made in conservative treatment of breast cancer are not always applicable owing to the risks of failure with such conservative approaches.

Adult↗

[Breast cancer: the role of scintigraphy in the initial evaluation and follow-up of patients with small tumors (T less than or equal to 3 cm)].

To evaluate the utility of bone scans for the follow-up of patients with small breast cancers (T less than or equal to 3 cm), the files for 133 patients whose disease was diagnosed between Jan. 1, 1979 and Dec. 31, 1980 were reviewed. At initial presentation, two of these patients already had bone metastases. During their disease course, 30 patients developed metastases and 16 of them had at least one bone metastasis. In 7 of these 16 cases, the bone metastasis was solitary; in 4 cases bone lesions were symptomatic. A total of 178 bone scans were performed during the follow-up of these 133 patients; 16 of these scans were positive, but only 4 examinations allowed the diagnosis of bone metastasis. Despite the slight prognostic value of initial bone scanning in this series, the technique is of little value unless it is combined with clinical examinations aimed at early detection of disease recurrence or metastasis. Except as part of clinical trial protocols, systematic bone scans appear unnecessary for the staging and follow-up of patients with small breast cancers.

Adult↗

[Apropos of 72 gynecomastia].

Sixty-nine cases of true gynecomastia are reported and etiological, clinical and surgical problems encountered in male senologic practice discussed. Endocrine and drug factors are well established, but half of the cases are idiopathic. Diagnosis is based on specific clinical, mammographic and histologic findings, treatment being surgical with or without fat aspiration or skin reduction.

Adipose Tissue↗

[Cavernous hemangioma of the spleen].

A cavernous hemangioma of spleen in a clinically asymptomatic patient presented in the form of a hyperechogenic mass on ultrasound imaging, becoming progressively hyperdense on the CT scan with contrast. This appearance, similar in all respects to that seen with cavernous hemangioma of liver, is rarely reported in the literature.

Angiography↗