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Biomedical subjects

M A Weinstein

Publications and source records attributed to M A Weinstein.

At least 19 recordsLinked to original sources
PubMed1992

Precise anorectal sphincter dilatation--its role in the therapy of anal fissures.

For the past 20 years, internal anal sphincterotomy has generally been considered to be the standard operation for an anal fissure. We sought an alternative form of treatment because of the wound complications inherent in this operation. Anal dilatation, precisely performed with a Parks' retractor opened to 4.8 cm or with a 40-mm rectosigmoid balloon, has been found to cure successfully the fissure in 93 percent and 94 percent, respectively, of each group and to be associated with fewer complications.

Adult↗
PubMed1992

Effects of neonatal exposure to the antiprogestin mifepristone, RU 486, on the sexual development of the rat.

RU 38486 (RU 486, mifepristone) is a potent progesterone receptor antagonist that has been used in humans in the pharmacologic induction of abortion. The effects of exposure to RU 486 during the neonatal period of the rat has not been previously reported. We examined the consequences of such exposure in the context of sexual development. Long-Evans rat pups were subcutaneously injected with either 100 micrograms RU 486, 300 micrograms RU 486, 500 micrograms progesterone (P), or 50 micrograms testosterone propionate (TP) in 0.05 ml sesame oil, or oil vehicle alone within 8 hours of birth, and 24 and 48 hours later. Treatment with either dose of RU 486 significantly advanced the onset of vaginal opening in females and attenuated defeminization of the lordosis response measured in males castrated as adults. As expected, TP-treated subjects were masculinized and defeminized, with females displaying fused vaginas and neither males nor females demonstrating lordosis behavior. Treatment with P caused no significant alterations in either the timing of vaginal opening or sexual behavior. These results indicate that RU 486 has clear developmental effects in the rat. Since this may well be a result of progesterone receptor blockade, further research is needed to clarify the processes involved.

Animals↗
PubMed1978

Dural arterio-venous malformations involving the cavernous sinus: a case report.

A case of dural arteriovenous malformation involving the cavernous sinus is reported. The patient was successfully treated with selective embolisation of the fistula. These patients constitute a distinct neuro-ophthalmological syndrome which may be very difficult to diagnose clinically because of the subtle signs and symptoms they present with. Angiography is necessary to make diagnosis and to differentiate these patients from those with the more common carotidcavernous fistulae.

Adult↗
PubMed1978

Diagnosis of juvenile angiofibroma by computed tomography.

Computed tomography (CT) accurately localized juvenile angiofibromata in 3 patients. The expanded pterygopalatine fossa and canal were visualized by CT in all three cases. Because of the hemorrhagic tendency of these tumors, a noninvasive modality such as CT is especially valuable in planning therapy.

Adolescent↗
PubMed1978

Interval computed tomography in multiple sclerosis.

Computed tomography demonstrated areas of abnormal attenuation in the white matter in 14 patients with multiple sclerosis (MS). Nine were studied two or more times. Acute MS lesions exhibit decreased or normal attenuation without contrast enhancement and increased attenuation with it. On later scans these lesions show decreased attenuation with or without contrast material. Some lesions remain decreased in attenuation and some become normal both with and without contrast material.

Adolescent↗
PubMed1977

Unhealed perineal wound: lavage with a pulsating water jet.

The use of the pulsating water jet lavage (Water Pik) in the care of the perineal wound is discussed. The relative case with which debridement of a difficult-to-locate perineal wound can be efficiently debrided and cared for by a patient on an ambulatory basis is stressed. This facilitates early patient hospital discharge and offers effective self-care to the patient.

Abscess↗
PubMed1977

Social injuries of the rectum.

Eleven patients with injuries of the rectum and sigmoid colon secondary to the insertion of the clenched fist are presented. Six patients sustained mucosal lacerations of the rectum and four patients had rectosigmoid perforations requiring laparotomy. One patient sustained a severe sphincter laceration producing complete anal incontinence. The management of these conditions is discussed.

Abdomen, Acute↗
PubMed1977

White and gray matter of the brain differentiated by computed tomography.

The white and gray matter of the brain can be clearly differentiated by computed tomography (CT). The differentiation is enhanced by the administration of contrast material. Without contrast material, the mean attenuation number of the white matter was 29 units, of the gray matter, 35 units. The effective low contrast resolving power of CT scanners can be clinically evaluated by comparing their ability to differentiate the white and gray matter of the brain.

Brain↗
PubMed1977

Basilar artery ectasia demonstrated by computed tomography.

Basilar artery eclasia was demonstrated by computed tomography (CT) in 4 cases. The course and diameter of the basilar artery as seen by CT closely approximated those aspects of the artery visualized by angiography. The clinical manifestations of basilar ectasia correlated with what brain stem structures were impinged upon by the ectatic artery.

Aged↗
PubMed1977

Demonstration of the superior ophthalmic vein by high resolution computed tomography.

Computed tomography has revolutionized the diagnosis of ophthalmologic and neuro-ophthalmologic disease. High resolution CT with thin-section techniques has made available the depiction of finer anatomic orbital detail and permits radiologic detection of more subtle lesions than was previously available. The display of normal-sized superior ophthalmic veins by CT is further evidence of the resolving power of the currently available machines. A segment of the superior ophthalmic vein was identified in 18 of 64 orbits examined by CT. Virtually the entire superior ophthalmic vein was identified in three orbits.

Arteriovenous Fistula↗
PubMed1977

Computed angiotomography.

Branches of the anterior and middle cerebral arteries and thalamostriate, septal, and internal cerebral veins can be clearly defined with computed tomography during contrast enhancement with the Ohio Nuclear Delta 25 scanner. Pathologic vessels can also be recognized. Visualization of vessels smaller than 1.5 mm belongs in the province of angiography.

Angiography↗