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Biomedical subjects

M A Stulova

Publications and source records attributed to M A Stulova.

At least 19 recordsLinked to original sources
PubMed2004

[Dilated cardiomyopathy resulting from asymptomatic and subclinical myocarditis].

The paper presents data on 10 patients with dilated cardiomyopathy (DCM) or chronic myocarditis with fatal outcomes in whom heart failure was preceded by abnormal ECG changes originally regarded as the manifestations of coronary heart disease or small myocardial infarction. The clinical course of the disease and morphological studies suggest that the ECG changes were associated with pre-existing asymptomatic viral myocarditis.

Adult↗
PubMed2003

[Long-term outcomes of viral myopericarditis in young patients].

Long-term follow-up (mean 14.1 +/- 6.6 years) of 54 young patients who have undergone acute viral myopericarditis of mild or moderate severity demonstrates a favourable outcomes in the majority of the examinees in spite of residual fibrous changes in the myocardium registered at ECG. Fibrous pericardial thickening detected in 89.4% patients at echocardiography is proposed as a differential-diagnostic indicator of old myopericarditis.

Acute Disease↗
PubMed2000

[Early ventricular repolarization as a probable consequence of acute viral and idiopathic myopericarditis].

64 patients who had acute viral or idiopathic myopericarditis (40 males and 24 females aged 16-48 years) were followed up for 3 to 24 years. Echocardiography has found thickening of the pericardium from 5 to 8 mm which corresponded to fibrosis in 55 patients (85.9%). Early repolarization was detected in 17 patients, in 14 of them it was associated with pericardial thickening (82.4%). Of 30 healthy controls, early repolarization in combination with pericardial fibrosis occurred in 6.7% of cases. In 7 patients with early repolarization ECG registered residual changes of the acute period, in 6 new changes arose--His block and left ventricular hypertrophy. It is suggested that in many cases early repolarization is not independent, it is sequelae of previous myopericarditis.

Action Potentials↗
PubMed2000

[Hypertrophic cardiomyopathy and viral, idiopathic myopericarditis].

Among 64 patients followed up for 3 to 24 years after acute viral or idiopathic myopericarditis 10 patients were found to have hypertrophic cardiomyopathy. At echo-CG they had asymmetric hypertrophy of the septum. Manifestations of acute myopericarditis, results of laboratory and functional investigations are presented. Hypertrophic cardiomyopathy runs asymptomatically or with few symptoms. The relations between cardiomyopathy and viral infection are discussed.

Acute Disease↗
PubMed1993

[Functional study of the heart valve apparatus by 2-dimensional Doppler echocardiography in rats with experimental endocarditis caused by Coxsackie B3 viruses].

Eleven neonatal cotton rats were infected with Coxsackie B3 viruses, 9 animals served as controls. The course of the disease was followed for 44 to 154 days. Electro- and phonocardiography, two-dimensional Doppler echocardiography, morphological and histological studies were performed in the experiment. All the histologically examined infected rats were found to develop myocarditis, whereas 75% of the animals had valvulitis. The total number of the afflicted values was 10, out of them the mitral, tricuspid, and pulmonary trunk valves accounted for 40, 40, and 20%, respectively. Doppler echocardiography revealed organic mitral and tricuspid insufficiencies in the outcome of valvulitis induced by Coxsackie B3 viruses due to the impairment of valvular cusp.

Animals↗
PubMed1993

[Physiological valvular regurgitation in healthy persons (its prevalence, hemodynamic characteristics and differential diagnosis)].

Two-dimensional Doppler echocardiography (DECG) was employed to examine for valvular regurgitation 100 healthy subjects. Physiological valvular regurgitation (PVR) was detected in 32 of them. It was defined as isolated pulmonary, isolated tricuspid, combined tricuspid and pulmonary, mitral in 17%, 9%, 4% and 2% of the examinees, respectively. Hemodynamically, PVR was characterized by low maximal speed of the flow and minimal extension. It should be noted that similar hemodynamic DECG parameters can be registered in minimal aphonic valvular regurgitation arising in latent rheumatic and viral endocarditides. This fact must be taken into consideration when making the differential diagnosis.

Adolescent↗
PubMed1992

[Abramov's "primary myocarditis", Fiedler's myocarditis and dilated cardiomyopathy].

After comparing the clinical and post mortem signs of myocarditis and dilated cardiomyopathy on the basis of correlating the reported data and own data on 28 patients with the appropriate descriptions by S. S. Abramov and A. Fiedler, the authors came to the conclusion that they had described two different diseases. S. S. Abramov had described dilated cardiomyopathy, whereas Fiedler acute diffuse myocarditis. The term Abramov-Fiedler myocarditis used in the Soviet literature does not correspond to the up-to-date classification of myocardial diseases. That is why it is required that these two concepts be separated to the benefit of the treatment.

Adult↗
PubMed1989

[The role of Coxsackie B viruses in the etiology of dilated cardiomyopathy].

In order to establish the relationship between Coxsackie B virus infection and dilated cardiomyopathy (DCMP), 53 patients suffering from DCMP underwent serological tests. The rate of demonstration of virus-neutralizing antibodies at different titres was compared with the respective values in the previously examined 180 patients with myocarditis, 58 patients with myocardial sclerosis and 150 normal persons. In DCMP, antibodies against B2 type virus were detectable more frequently (p less than 0.001) and at higher titres (p less than 0.05) that in normal persons. Antibodies at the titres greater than 1:128 were most demonstrable in myocarditis and then at an equal rate in DCMP and focal myocardial sclerosis following Coxsackie myocarditis. The conclusion is drawn about the relationship between Coxsackie infection and DCMP as well as between DCMP and myocarditis. The reported data on the mechanisms by which myocarditis progresses to DCMP are discussed.

Adolescent↗
PubMed1985

[Viral myocarditis (the etiologic, clinical, diagnostic and treatment problems)].

To elucidate the etiology of respiratory infection and pharyngitis associated myocarditis a serological study was made of 201 patients who were successively admitted with a clinical diagnosis of myocarditis. Coxsackie viral infection of group B, influenza A and B, para-influenza and adenoviral infection and beta-hemolytical streptococcus of group A were determined. Preceding Coxsackie infection was established in 38,3% of the patients, influenza A and B in 27.5%, adenoviral infection in 3.6% and para-influenza in 1.7%. beta-hemolytical streptococcus as the cause of myocarditis was detected in 4.9% of the patients only. In view of the viral etiology of most cases of myocarditis the authors discussed the problems of its pathogenesis, clinical course and therapy.

Adenoviruses, Human↗
PubMed1984

[Myocarditis caused by Coxsackie B viruses in adults].

Two hundred and thirty-eight patients with a clinical and electrocardiographic diagnosis of myocarditis and two control groups were examined for virus-neutralizing antibodies against Coxsackie B1-6 viruses. Serological evidence for preceding Coxsackie infection was demonstrated by 40.9% of myocarditis and in 29.3% of myopericarditis patients. Coxsackie B2 and B4 viruses were the most prevalent. The patients manifested a significant increase in the antibody titer as compared with the control group.

Adolescent↗