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Biomedical subjects

M A Stone

Publications and source records attributed to M A Stone.

51 records · Page 3Linked to original sources

Psychology of office design.

The design of a physician's office can affect whether patients return, follow advice, or recommend the physician to other people. Color is an important element in design. It can make people relaxed or excited; it can help or hinder vision. Decreased color perception and differentiation occurs with increased age. In addition, color reflects the personality of the person who chooses or uses it. Furniture also reflects personality. Arrangement is important in making people feel comfortable and easy and safe to move between pieces. Most people prefer to sit alone when waiting to see physicians. Firm-cushioned furniture with arm rests allows people to sit and rise more easily. Color, mirrors, glass, and other decorating items can help make a small space look larger, a narrow space wider, or a low space higher. Mixing textures creates interesting effects. Patterns in wall coverings and upholstery also increase visual interest and alter perception of size and shape. Personal mementos can make patients feel a physician is a more humane person, although they also can make a female physician appear less professional and capable, depending on the patients' perceptions. Even lighting levels increase visual acuity. People usually prefer some closeness in architecture as a defensive position. Institutionalized approaches to building increase patients' anxiety. The reception area makes the first impression. It should be welcoming, restful and divided into smaller waiting areas. Incandescent lighting is more relaxing than fluorescent.(ABSTRACT TRUNCATED AT 250 WORDS)

Facility Design and Construction↗

Computer-based monitoring of clinical care in a public psychiatric hospital unit.

A computer-based clinical monitoring system on a 40-bed university hospital psychiatric unit provides documentation to justify clinicians' diagnosis and choice of treatment and facilitates evaluation of patients' progress at scheduled intervals. The microcomputer system was developed to meet state guidelines for monitoring patients receiving neuroleptic drug treatment. A weekly status report generated for each patient alerts the treating physician to cases in which data do not justify clinical decisions, identifies potential problems, and suggests considering for discharge patients whose symptoms have sufficiently abated. The system is also useful in supervision and research.

Diagnosis, Computer-Assisted↗

Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland.

The effects of lithium and cholinergic stimulation on inositol phospholipid metabolism have been assessed using rat parotid gland slices and isolated acinar cells labelled with 32Pi. Cholinergic stimulation using carbachol caused substantial breakdown of phosphatidylinositol 4,5-bisphosphate (PtdInsP2) and enhanced labelling of phosphatidate (PA) and phosphatidylinositol (PtdIns). Lithium alone had little effect upon 32Pi incorporation, but in combination with carbachol it greatly reduced the PtdIns labelling response to the agonist. Instead the label accumulated in a lipid identified as cytidine monophosphorylphosphatidate. There was also an enhancement of the PA labelling response to carbachol. These lithium-induced alterations in agonist-stimulated phospholipid metabolism were reversed if 10-30 mM-inositol was included in the incubation medium. Despite reduced PtdIns synthesis, lithium had relatively little effect on polyphosphoinositide labelling in stimulated cells. Resynthesis of polyphosphoinositides was monitored in acinar cells that had been stimulated with carbachol and then treated with atropine to block muscarinic receptors. Treatment with lithium during the carbachol-stimulation phase reduced the rate of phosphatidylinositol 4-phosphate synthesis, but had no significant effect upon PtdInsP2. The results suggest that an active inositol phosphatase pathway is essential to maintain intracellular inositol levels, but that PtdInsP2 synthesis is not markedly reduced by a substantial fall in intracellular inositol. This implies a close control over the rates of PtdInsP2 breakdown and resynthesis during agonist stimulation.

Animals↗

A comparison of the binding of sigma opioids and phencyclidine, and the interaction with antipsychotic drugs in rat brain membranes.

The present study investigates the relationship between binding at the sigma site labelled by the prototypic sigma ligand (+)-[3H]-N-allylnormetazocine [+)-[3H]-SKF10,047) and binding at the phencyclidine (PCP) site labelled by [3H]-phencyclidine in rat whole brain membranes. (+)-[3H]-SKF10,047 bound with a KD of 251 +/- 66 nM. [3H]-PCP bound with a KD of 180 +/- 35 nM (KD +/- asymptotic s.e.). The potencies of a range of compounds to displace these ligands were only poorly correlated (r = 0.3). Furthermore selective displacement of (+)-[3H]-SKF10,047 but not of [3H]-PCP was demonstrated using the non-selective dopamine ligand haloperidol and the dopamine2-selective ligand 3-(3-hydroxyphenyl)N-n-propylpiperidine (3PPP). These results indicate that the sigma and PCP sites are different entities. The relationship between binding at the sigma site and dopamine receptors was investigated in rat whole brain membranes and in striatal membranes. (+/-)-SKF10,047 displaced [3H]-haloperidol bound to whole brain membranes with a greater potency than it displaced [3H]-haloperidol bound to striatal membranes. The opposite was true for the dopamine antagonist, clozapine, which showed greater potency in striatal membranes. Comparison of [3H]-haloperidol binding in whole brain and striatum gave only a poor correlation (r = 0.6). Hence, different binding sites would appear to exist in these brain regions, the binding of [3H]-haloperidol to whole brain being predominantly to sigma sites and the binding to striatum being predominantly to dopamine receptors.

Animals↗

Increased risk of infection with Helicobacter pylori in spouses of infected subjects: observations in a general population sample from the UK.

BACKGROUND/AIMS: To investigate risk factors for infection with Helicobacter pylori in a general population sample who accepted an invitation to be screened. In particular, to determine whether being the spouse of an infected subject is an independent risk factor for infection after adjustment for other risks. METHODOLOGY: A serological screening test for Helicobacter pylori was offered to 4015 randomly selected subjects registered at a single general practice in Market Harborough, UK. Those invited were also asked to complete a questionnaire if attending for screening; this included information relating to possible risk factors for infection. Results were analyzed in the overall sample of attenders and a subset of married couples, using univariate and multivariate analyses. RESULTS: Complete results were obtained for 1431 (36%) subjects. Age, childhood social class and household crowding in childhood were independent risk factors after adjustment for other variables. Positive status of spouse was an independent risk factor in a subset of 389 married couples (P = 0.005, Odds Ratio: 2.65, 95% Confidence Interval: 1.34-5.25). CONCLUSIONS: Our study confirmed the correlation between childhood living conditions and infection with Helicobacter pylori. In the study population, having a Helicobacter pylori-positive spouse was associated with a significant increased risk of being infected.

Adult↗

An audit of ultrasound guided liver biopsies: a need for evidence-based practice.

BACKGROUND/AIMS: This report examines complication rates associated with liver biopsies performed under ultrasound guidance. MATERIAL AND METHODS: Following the introduction of a policy of performing all liver biopsies under ultrasound guidance in the radiology department, 168 such procedures were reviewed. RESULTS: The post biopsy bleeding rate 4.2% was high compared to published national figures, which varied widely. CONCLUSION: Our audit did not necessarily support the argument that ultrasound guidance leads to safer liver biopsy, but did support the need for randomized controlled trials of blind and guided liver biopsy to compare safety. The clinical impression gained from the audit was that the change in policy has reduced mortality associated with liver biopsy at this hospital and in the absence of further evidence, the present policy will continue. A further issue raised by the audit was the appropriateness of liver biopsy in terminally ill patients.

Humans↗