Chromosomes of cancer cells.
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Biomedical subjects
Publications and source records attributed to M A Stanley.
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This study examined the prevalence and nature of schizotypal features in obsessive-compulsive disorder (OCD). Although this symptom pattern has been related retrospectively to treatment resistance, no prospective data have addressed such an hypothesis. This study sets the stage for further work in this arena by prospectively identifying and characterizing a schizotypal subset of OCD patients. Twenty-eight percent of the sample had schizotypal features, although only 8% met criteria for schizotypal personality disorder. Social-evaluative concerns and psychotic-like symptoms characterized this subgroup. Schizotypal patients did not differ from nonschizotypes with regard to anxiety, depressive, or obsessive-compulsive symptoms.
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The pathophysiology of trichotillomania (TM) is not well understood. Overlap with obsessive compulsive disorder (OCD) has been proposed, although extant data are inconsistent in this regard. In the neuropsychological domain, some data have supported the proposed TM-OCD overlap. However, the available studies are limited in number, and they typically have sampled a restricted range of performance domains. To examine further neuropsychological functioning in TM, the present study compared performance of 21 patients with TM and 17 normal control (NC) participants on a broad battery of tests assessing intellectual functioning, auditory perception and language, visual perception, somatosensory function, motor ability, memory, concept formation, attention and information processing speed, impulsivity, and cerebral dominance. The TM group demonstrated poorer performance on all measures of divided, but not focused, attention. Correlational data suggested the potentially important role of negative affect in TM. Implications of the data for the conceptualization of TM are discussed.