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Biomedical subjects

M A Simpson

Publications and source records attributed to M A Simpson.

At least 73 records · Page 4Linked to original sources
PubMed1986

Medication as a potential cause of depression.

Many different drugs have been reported to cause depression. The substantive literature is reviewed, with particular attention to antihypertensive and cardiac drugs, oral contraceptives, levodopa and major tranquilizers. The nature of the relationship between physical illness, therapeutic drug use and the potentiation or precipitation of depression is explored.

Antihypertensive Agents↗
PubMed1982

The use of elicited imitation as a measure of expressive grammar: a question of validity.

Elicited imitation has been suggested as an alternative to Developmental Sentence Scoring (DSS) as a means of measuring grammatical performance. Numerous investigators, however, have demonstrated that short-term memory is a confounding variable during elicited imitation. In the first experiment the imitative skills of 4 year old were assessed as a function of sentence comprehension and delayed imitation. The second experiment examined the relationship between the Carrow Elicited Language Inventory (CELI) and DSS under three imitative conditions; 0, 3, and 5 second delays. Results indicated that subjects were able to accurately repeat sentences which they did not understand as long as imitation was immediate. Delaying imitation 3 seconds adversely affected imitation of noncomprehended sentences while having no significant effect on comprehended sentences. A 3 second delay on the CELI also improved its correlation with DSS from -.77 (standard procedures) to -.90. The validity of elicited imitation as a test of expressive grammar is challenged.

Child Language↗
PubMed1979

Death education--where is thy sting?

We are not free to choose whether anyone will learn about death, though we have some choice about how they will learn. The author discusses the basic questions that need to be answered in planning death education at any level, and the possible goals, in terms of cognitive gain, skills, and attitudinal objectives. Some principles in regard to teaching methods and evaluation are described, with illustrations from the experiences of medical students and others. It is important that the teacher should be able to deal with the problems that such programs may arouse. Cheap emotional arousal is easy to produce, but trivial, unless creatively used for a valued purpose and adequately resolved. Death is infinitely exploitable, and the growth of death voyeurism via "education" is alarming. The capacity to recognize and avoid being exploited or exploiting others must be one of our principle educational objectives.

Attitude to Death↗
PubMed1978

Spectrophotometric determination of lymphocyte mediated sheep red blood cell hemolysis in vitro.

An assay has been developed in which the degree of in vitro spleen cell-mediated sheep red blood cell (SRBC) hemolysis is quantitated spectrophotometrically (QHS). Immune mouse spleen cells, SRBC and guinea pig complement were incubated at 37 degrees C for 1 h in buffer, centrifuged, and the supernatant solutions read at 413 nm. The greatest degree of cell-mediated SRBC hemolysis was observed in day +5 harvested spleens following a day 0, 5% SRBC i.p. injection. In the assay system, it was found that a stimulator SRBC dose of 0.2% resulted in maximal stimulation with little non-specific hemolysis. This assay is presented as an alternative to the well established plaque forming and rosette assays.

Animals↗