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Biomedical subjects

M A Raggi

Publications and source records attributed to M A Raggi.

At least 55 records · Page 3Linked to original sources
PubMed1993

X-ray fluorescence determination of bromine traces in pharmaceutical formulations containing sodium diclofenac.

The X-ray fluorescence spectroscopy (XRF) on solid samples is applied to the organic bromine impurities assay on pharmaceutical formulations of sodium diclofenac (DCF). A wide range of Br contents (7-1564 ppm) in the tablets is obtained, depending on manufacturer source and batch preparation. As the impurities concern only the sodium diclofenac employed, and the presence of Br might be a toxicity index arising from the synthetic procedure, the assay of each DCF batch is suggested.

Bromine↗
PubMed1991

Spectrophotometric determination of glutathione and of its oxidation product in pharmaceutical dosage forms.

A simple and sensitive spectrophotometric method suitable for the stability control of pharmaceutical dosage forms containing glutathione (gamma-glutamyl-cysteinyl-glycine), GSH, is described. Besides GSH, the method quantitatively determines its oxidation product, GSSG. The colour reactions of GSH and GSSG with ammonium tetrachloropalladate have been investigated and the optimum reaction conditions, spectral characteristics and composition of the yellow water-soluble complexes have been established. The assay results of pharmaceutical formulations showed good accuracy and precision over the concentration range of 5 x 10(-5)-6 x 10(-4) M GSH.

Amino Acid Sequence↗
PubMed1989

Determination of potassium in pharmaceutical formulations by means of 18-crown-6: extraction studies.

A colorimetric method has been developed for the determination of potassium in pharmaceutical formulations. The method is based on the formation of a complex of potassium with 18-crown-6, followed by conversion to an ion-pair with picrate anion; the ion-pair is extracted with either methylene chloride or toluene-methylene chloride (80:20, v/v) and determined colorimetrically.

Colorimetry↗
PubMed1989

[Gas chromatographic determination of aluminum in pharmaceutical formulations].

A gas chromatographic method for the determination of Al3+ in pharmaceutical formulations, based on the complex formation between the cation and the trifluoroacetylacetone reagent is reported. The results obtained indicate that the proposed method is suitable, on account of accuracy and precision, for a reliable quality control of commercial dosage forms.

Aluminum↗
PubMed1988

Determination of amiodarone hydrochloride in pharmaceutical formulations by derivative UV spectrophotometry and high-performance liquid chromatography (HPLC).

Assay procedures based on derivative ultraviolet spectrophotometry and high-performance liquid chromatography (HPLC) have been developed for the specific determination of amiodarone hydrochloride in pharmaceutical dosage forms. The use of first- and second-order derivative spectrophotometry was found to have suppressed the background absorption from the excipients with comparable accuracy and precision to the reversed-phased HPLC reference method. A conventional UV absorption method (lambda = 242 nm) is subject to possible interference by formulation excipients.

Amiodarone↗
PubMed1987

Analysis of nandrolone esters in oily injections by reversed-phase high-performance liquid chromatography.

A specific liquid chromatographic (HPLC) procedure is presented for the analysis of nandrolone esters (phenylpropionate, decanoate and undecanoate) in commercial oily injections. The analysis was carried out under isocratic, reversed-phase (RP8 column) conditions using a UV detector (240 nm). The system discriminates between nandrolone alcohol, a potential impurity, and its esters and permits the quantitation of trace benzaldehyde derived from the oxidative degradation of benzyl alcohol. The proposed HPLC method was found to be more specific and accurate than the pharmacopoeial spectrophotometric assay procedure (isoniazid reagent). The interference of benzaldehyde with the isoniazid method was also investigated.

Journal Article↗