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Biomedical subjects

M A Persinger

Publications and source records attributed to M A Persinger.

At least 253 records · Page 14Linked to original sources
PubMed1987

Electroencephalographic correlates of temporal lobe signs and imaginings.

Significant correlations (0.50) were observed again between scores for the Wilson-Barber Inventory of Childhood Memories and Imagings and the numbers of experiences that are indicative of temporal lobe lability. In addition, positive correlations (0.42) occurred between temporal lobe EEG measures (scalp electrodes) and numbers of temporal lobe signs. The numbers of alpha seconds per minute from the occipital lobes were correlated (0.57) with the Wilson-Barber cluster that indicated interests in "altered states". Scores on the childhood imaginings section of the Wilson-Barber Inventory were correlated (0.44) with the numbers of spikes per minute over the temporal lobes when the eyes were closed.

Adolescent↗
PubMed1987

Possible learned detection of exogenous brain frequency electromagnetic fields: a case study.

Zener card representations were presented visually for 15 sec. every 30 sec. for a total of 40 trials per session over 17 sessions to a single subject who displayed temporal lobe lability. During the 15 sec. before the presentation of one of the symbols (target) either a specific 4-Hz magnetic field pattern or a 1-Hz or 7-Hz magnetic field was presented bilaterally at the level of the temporal lobes. Field strengths were in the order of milligauss (about 1000X background values). The subject was required to anticipate the next symbol for each trial. Only when the 4-Hz field preceded the target symbol did the subject's accuracy of guessing remain systematically above (50%) chance (20%) over the sessions. These results suggest that exogenous magnetic fields may become discriminative stimuli through temporal association. Evidence of habituation was also obtained.

Brain↗
PubMed1986

Geophysical variables and behavior: XXXIII. Onsets of historical and contemporary poltergeist episodes occurred with sudden increases in geomagnetic activity.

Several researchers have reported that poltergeist episodes frequently begin on the day (+/- 1 day) of a sudden and intense increase in global geomagnetic activity. To test this visual observation, a near-complete account of these episodes for which the inception dates were recorded and verified was examined. Statistical analyses clearly indicated that global geomagnetic activity (aa index) on the day or day after the onset of these episodes was significantly higher than the geomagnetic activity on the days before or afterwards. The same temporal pattern was noted for historical cases and for those that have occurred more recently. The pattern was similar for episodes that occurred in North America and in Europe. The results were statistically significant and suggest that these unusual episodes may be some form of natural phenomena that are associated with geophysical factors.

Geological Phenomena↗
PubMed1985

Geophysical variables and behavior: XXIII. Relations between UFO reports within the Uinta Basin and local seismicity.

A strong temporal correlation was found between the numbers of reports of UFOs (unidentified flying objects) and nearby seismic activity within the Uinta Basin for the year 1967. The numbers of UFO reports per month during this classic UFO flap were correlated 0.80 with the sum of the earthquake magnitudes per month for events within 150 km of the report area. Numbers of UFO reports were not correlated significantly with earthquake activity at distances greater than 150 km but less than 250 km away. The strongest correlation occurred between UFO reports and nearby seismic activity within the same month but not for previous or consequent months. Close scrutiny of daily shifts in epicenters and reports of UFOs indicate that they occurred when the locus of successive epicenters shifted across the area. These analyses were interpreted as support for the existence of strain fields whose movements generate natural phenomena that are reported as UFOs.

Behavior↗
PubMed1985

Geophysical variables and behavior: XXI. Geomagnetic variation as possible enhancement stimuli for UFO reports preceding earthtremors.

The contribution of geomagnetic variation to the occurrence of UFORs (reports of UFOs) within the New Madrid States during the 6-mo. increments before increases in the numbers of IV-V or less intensity earthquakes within the central USA was determined. Although statistically significant zero-order correlations existed between measures of earthquakes, UFORs and geomagnetic variability, the association between the latter two deteriorated markedly when their shared variance with earthquakes was held constant. These outcomes are compatible with the hypothesis that geomagnetic variability (or phenomena associated with it) may enhance UFORs but only if tectonic stress and strain are increasing within the region.

Behavior↗
PubMed1985

Geophysical variables and behavior: XXII. The tectonogenic strain continuum of unusual events.

Transient and very localized geophysical forces are hypothesized to be a major source of phenomena that have been traditionally labelled as haunts and poltergeists. They would be generated by increasing tectonic stresses and would display electromagnetic and gravitational characteristics. Materials would be influenced according to their physical properties. Dielectric materials would respond differently from conductors. Organic semiconductors, of which the human being is an important subcategory, would be affected as well. The conspicuous overlaps between (non-convulsive) complex partial epilepsy and many episodes of poltergeists and haunts are expected in light of the direct stimulation of the observer's brain by the transient, intense magnetic fields and the liability of temporal lobe structures. Implications and some general predictions for the distribution of these phenomena in time and space are discussed.

Behavior↗
PubMed1985

Geophysical variables and behavior: XXV. Alterations in memory for a narrative following application of theta frequency electromagnetic fields.

Subjects were asked to listen to a 3-min. narrative. During Min. 1, 2, or 3 of the narrative, subjects were exposed for 60 sec. to either 5-Hz or 20-Hz electromagnetic fields or to a sham field condition. The fields were generated by commercial devices and applied externally to the side of the head at the level of the temporal lobe. The transcript of each subject's version of the narrative was evaluated by discourse analyses for the numbers of direct recalls or of inferences for each of the three segments. Subjects who had received the 5-Hz fields during Min. 1 and 2 of the narrative displayed twice as many inferences for the material that had been presented during Min. 1 only compared to the 20-Hz groups who did not differ from the sham-field subjects. We hypothesize that there are small alterations in the processing of complex series of verbal stimuli by these weak, theta frequency electromagnetic fields. They might not affect the amount of recall but they may influence the details of recall.

Adolescent↗
PubMed1985

Geophysical variables and behavior: XXVI. A response to Rutkowski's critique of the tectonic strain hypothesis for UFO phenomena.

The tectonic strain hypothesis for many reports of UFOs (UFORs), primarily odd luminosities and metallic-looking phenomena, has been criticized on the basis of inadequate data. This reply begins with the distinction between the empirical basis for the association between UFORs and seismic activity, the hypothesis, and laboratory experiments. It is emphasized that criticisms of data should be based upon empirical criteria rather than value judgments about scientific credibility. Multivariate and bivariate analyses have indicated systematic relationships between UFORs and earthquake measures within several different areas and for different historical periods. However, the physical mechanisms for the generation of individual UFO events and their relationship to UFORs require closer examination.

Disasters↗
PubMed1985

Death anxiety as a semantic conditioned suppression paradigm.

Death anxiety and more severe forms of thanatophobia are encountered frequently in the clinical population. However, approaches that allow behavioral solutions to these experiences are conspicuously absent in the literature. From an operant perspective, death anxiety arises from repeated exposures to direct and implicit forms of the statement "I will die". It is the semantic equivalent of a conditioned suppression paradigm. Historically, the human organism has attempted to reduce the aversive consequences of this reinforcement schedule by extinguishing one of its three components. The "solutions" characterize the fundamental philosophical and religious treatments of death anxiety. A behavioral semantics approach is proposed as suitable for dealing with death anxiety of a religious, educated young adults, particularly those dying of terminal diseases.

Anxiety↗
PubMed1985

Temporal lobe signs: electroencephalographic validity and enhanced scores in special populations.

Internal and external validity tests were completed for an inventory that has been used to infer signs of temporal lobe lability. Strong, positive correlations were reported for a normal (reference) population between the numbers of responses that referred to paranormal experiences (including feelings of a "presence") and separately to religious beliefs and the numbers of spikes per minute within electroencephalographic recordings from the temporal lobe. Numbers of spikes were also correlated with the subjects' scores on the hysteria, schizophrenia, and psychasthenia scales from the MMPI. These clusters of items were not correlated with electrical activity from the occipital lobe (the comparison region). Numbers of responses to control clusters of mundane experiences were not correlated with the temporal lobe measures. A group of student poets scored higher on different subclusters of temporal lobe signs and on the schizophrenia and mania scales of the MMPI than the reference group. For both groups, there were positive correlations between the amount of alpha activity in the temporal lobe only and answers to items such as "hearing inner voices" and "feeling as if things were not real." These results demonstrate that quantitative measures of electrical changes in the temporal lobe are correlated with (or with the report of) specific experiences that are prevalent during surgical or epileptic stimulation of this brain region.

Adult↗
PubMed1985

Temporal lobe signs and reports of subjective paranormal experiences in a normal population: a replication.

Correlations (r = 0.50) were found between the numbers of different psi (paranormal) experiences and the numbers of temporal lobe signs within a population of university students (n = 99). The strongest correlation of 0.60 occurred with a cluster of signs that are similar to symptoms reported by patients who show chronic foci in the mesiobasal temporal lobe. However, there were no significant correlations between numbers of different psi experiences and clusters of control items or a lie scale. Specific analyses of the 140 items of the inventory indicated only 23 reached statistical criterion (p less than .001). Of these 17 were direct temporal lobe signs that implied deepened affect, auditory-vestibular experiences (vibrations, hearing one's name called), olfactory auras, perseveration ("forced" thinking), depersonalization, and sense of the personal. Five items involved beliefs about exotic phenomena or philosophical ideas. Only one item was from a control cluster. These results support the hypothesis that mystical or paranormal experiences are associated with transient electrical foci within the temporal lobe of the human brain. The repeated occurrence of these experiences within normal individuals may be embedded within a more complex symptomatology of temporal lobe signs.

Adolescent↗
PubMed1984

Striking EEG profiles from single episodes of glossolalia and transcendental meditation.

Transient, focal, epileptic-like electrical changes in the temporal lobe, without convulsions, have been hypothesized to be primary correlates of religious experiences. Given these properties, direct measurement of these phenomena within the laboratory should be rare. However, two illustrated instances have been recorded. The first case involved the occurrence of a delta-wave-dominant electrical seizure for about 10 sec. from the temporal lobe only of a Transcendental Meditation teacher during a peak experience within a routine TM episode. The second case involved the occurrence of spikes within the temporal lobe only during protracted intermittent episodes of glossolalia by a member of a pentecostal sect . Neither subject had any psychiatric history. These observations are commensurate with the hypothesis that religious experiences are natural correlates of temporal lobe transients that can be detected by routine EEG measures.

Adult↗
PubMed1984

People who report religious experiences may also display enhanced temporal-lobe signs.

Religious and god-related experiences have been hypothesized to be a portion of the continuum of phenomena that are generated by endogenous, transient electrical stimulation within deep structures of the temporal lobe. According to this hypothesis, normal people, without psychiatric history, who report intense religious experiences should also demonstrate a wide range of temporal lobe-related private behaviors. To test this prediction, a self-report inventory that contained 140 temporal-lobe-relevant information, opinion-belief, and sampled MMPI statements was administered to two separate groups (n = 108; n = 41) of male and female first-year university students. In Study I, subjects who had reported religious experiences, particularly those who did not attend church regularly, scored significantly higher on a variety of statement clusters (n = 7 to 14 items) that contained temporal-lobe symptomology relative to groups who did not report religious experiences and did not attend church regularly. In Study II subjects, regardless of church attendance, who reported religious experiences scored significantly higher on the temporal-lobe clusters. People who reported religious experiences were more likely to have kept a dairy and to enjoy poetry reading or writing. However, religious experiments and churchgoers did not score higher (in either experiment) on clusters that contained mundane psychological or proprioceptive statements, descriptions of odd sensations, or modified portions of the Lie scale from the MMPI.

Adult↗
PubMed1984

Propensity to report paranormal experiences is correlated with temporal lobe signs.

Bivariate correlation analyses indicated that people who reported greater numbers of different types of paranormal experiences also reported greater numbers of temporal lobe signs. Whereas responses of one group (n = 108) of male and female university students gave a correlation of 0.60 between the two measures, for another group (n = 41) the correlation was 0.72. Partial correlation analyses, which involved holding the shared variance with affirmative responses to mundane psychological statements or odd sensations constant, did not alter the strength of the relationship. These results support the hypothesis that spontaneous paranormal experiences and the psychological components of complex partial (psychomotor) epilepsy may exist along the same continuum of temporal lobe sensitivity.

Electroencephalography↗
PubMed1983

Degranulation of brain mast cells in young albino rats.

Quantitative measurements were made of brain mast cell (MC) degranulation in juvenile albino rats. Neither acute nor chronic intraperitoneal injections of Compound 48/80 (C 48/80) evoked any clear degranulation. Fifteen to thirty minutes after the injection of either C 48/80 or physiological saline into the right anterior thalamus, frank degranulation in the leptomeninges and some degranulation in the parenchyma were evident. The injected sides contained about twice as much degranulated cells as the noninjected sides. In a second experiment, animals were killed 10, 100, 1000, and 10,000 min after a single 10-microliters injection of C 48/80 into the anterior thalamus. Although about 40% of the leptomeningeal and 20% of the parenchymal MCs were degranulated within 10 min, more than 50% of the MCs in both areas were degranulated within 100 min after the injection. More extensive degranulation was evident at both times within the parenchyma of the injected sides. Degranulated MCs were not obvious after this period although nuclei surrounded by sparse granules (in the parenchyma) or by fused, globular metachromatic material (in the leptomeninges or their ventricular processes) were still discernable 7 days later. The implications of brain mast cell degranulation for psychoneuroimmunology are considered.

Animals↗
PubMed1983

Mast cell numbers in incisional wounds in rat skin as a function of distance, time and treatment.

The dynamic changes in skin mast cell (MC) numbers around incised wounds were studied, using experimental designs amenable to multiple analyses of variance. Sixty-four Wistar albino rats were shaved in the interscapular region, wounded or not wounded, and then killed 2 or 10 days later. During this period, the rats were exposed continually to a cold (2 degrees C) or control (20 degrees C) climate and treated daily over the shaved region with either tap water or a weak sulphuric acid (pH 3.5) solution. The MCs within five adjacent fields of the wound or the control reference and within the superficial and deep halves of the skin were counted (at x 400). The greatest decrease in MC numbers occurred within about 700 microns of the wound. Whereas the paucity of MCs within the wound region was evident at 2 days, near-normal levels were achieved by day 10. Cold exposure produced little effect, but MCs responded differently to the water and acid treatments as a function of distance and skin depth.

Abdomen↗
PubMed1983

Winter blahs and spring irritability: the chronic but subtle behavioral operations.

Operation analyses, for which behavioral and environmental events are translated into reinforcement schedules, indicate that winter depression and spring irritability reported by people living in northern climates are dominated by four paradigms. They are (1) a shift in the ratio of negative to positive stimuli, (2) stimulus redundancy and satiation, (3) coerced hypoactivity or attenuation of free operant behavior, and (4) conditioned suppression or anxiety due to the progressive escalation of negative stimulus presentations. The chronic effects of these schedules on the behaviors of people living in cold climate during the winter season are discussed.

Anxiety↗