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Biomedical subjects

M A Pearson

Publications and source records attributed to M A Pearson.

32 records · Page 2Linked to original sources
PubMed1993

Identical mitochondrial DNA deletion in mother with progressive external ophthalmoplegia and son with Pearson marrow-pancreas syndrome.

We describe a family in which the mother has progressive external ophthalmoplegia with the common 4977 base pair deletion, and her son has a syndrome similar to the Pearson marrow-pancreas syndrome with the identical deletion. This case extends the clinical phenotype of the Pearson syndrome and raises the possibility that developmentally regulated tissue-specific nuclear factors are responsible for the differential phenotypic expression of these two mitochondrial disorders.

Adult↗
PubMed1991

EEG evidence that morphine and an enkephalin analog cross the blood-brain barrier.

The ability of naltrexone but not methyl naltrexone to cross the blood-brain barrier (BBB) was used to provide a different approach for the demonstration that opiates can enter the brain. Cortical electroencephalographic (EEG) measurements were made in rats receiving peripheral (IP) injections of naltrexone or methyl naltrexone and morphine or an enkephalin analog [Tyr-D-Ala-Gly-MePhe-Met(O)-ol]. Naltrexone significantly blocked the EEG effects of morphine and the enkephalin analog, but methyl naltrexone failed to do so. The results provide biological evidence that an opiate peptide can cross the BBB to affect the activity of the brain.

Amino Acid Sequence↗
PubMed1989

Mortality from unintentional injuries in California, 1985.

In 1985 unintentional injuries were the fourth leading cause of death among California residents, causing 10,380 deaths. They were the leading cause of potential life lost, accounting for 278,109 years lost. This was more than twice the number of years lost due to heart disease and 1 1/2 times the number lost due to cancer. Motor vehicle traffic accidents were the leading cause of unintentional injury deaths, accounting for half (5,158) the deaths. The next two leading causes were poisoning (especially for men aged 25 to 44 years) and falls (especially among persons aged 75 and older). Drowning was second to motor vehicle accidents as a cause of death in children aged 1 to 14 years. California's age-adjusted injury mortality rates in 1985 were lower in coastal and urban counties than in inland and rural counties, and these rates were generally lower in counties having organized systems of trauma care.

Accidents↗
PubMedDate not supplied

Therapy with felony-convicted male juvenile offenders.

Crime among youth is one of America's fastest growing problems. Crimes of violence and aggression against persons and property are increasingly disturbing to the American public. Frequently, these problems are dealt with from a judicial perspective only, without regard for underlying problems. There is little or no access to health care, especially mental health care, for these troubled youths and their families. The role of the juvenile justice system was established on the basis of the philosophical principle of "parens patriae." This concept establishes the state as the higher or the ultimate parent of all within its borders. Unfortunately, this system falls short of fulfilling that obligation. Thus, these children are not accorded the protection that is given to adults nor the care and rehabilitation recommended for children. The purpose of this paper is to describe one program that combines the judicial needs of the state with comprehensive mental health services for juvenile offenders on intensive probation. The lives of these young males and their families is examined. The rewards and the disappointments in working with this extremely challenging group are shared. Specific therapeutic interventions and barriers to therapy are presented.

Adolescent↗