Biomedical subjects
Publications and source records attributed to M A Parfenova.
Regional changes of circulation after injection of pirroxan, obsidan and ornid depended on functional state of rats. The differences were significant in systemic hemodynamic and regional changes of resistive, transcapillary exchange and the blood volume function of the circulation.
Emotional stress was stimulated by placing rats in a tight cage (moderate stress) or fixing them rigidly on a bench (marked stress) for 1 hour. In moderate emotional stress, the coronary fraction of cardiac output and effective myocardial blood supply declined considerably. Marked emotional stress caused a similar reduction in the cardiac output coronary fraction, whereas effective myocardial blood supply was not reduced, but, on the contrary, tended to increase. The decrease in coronary fraction was not related to adrenergic effects. Marked emotional stress provoked regional changes in the resistance, microcirculatory and capacity components of the vascular bed, an adaptation to enable effective myocardial blood supply and enhance cardiac activity. It was accompanied with kallikrein-kinin activation.
A preliminary pharmacological desympathization (pirroxan, obzidan, ornid) decreased blood pressure, heart rate, cardiac output, and increased total vascular resistance in immobilized rats. The fraction of cardiac output decreased in lung (bronchial blood flow), liver and myocardium and increased in other organs and tissues. Relative blood supply increased in expansive regions of the skin, muscles and splanchnic organs but decreased in the liver. Opposite changes of transcapillary permeability were found in vascular regions of the skin and skeletal muscles as well as in splanchnic organs.
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The main characteristics of systemic hemodynamics and relative changes in the blood content, blood flow and uptake of intravenous 86Rb in several tens of organs, tissues and parts of the body were examined in rat experiments 6 days after ligation of the common bile duct. This made it possible to appraise the resistive, capacitance and capillary constituents of the general peripheral vascular resistance. In this case the fractions of cardiac discharge diminished in a number of the internal organs of the abdomen and increased in muscle and bone tissues of the chest. The signs of extensive venodilation were defined, with these signs being the least remarkable in the liver and lungs. Transcapillary permeability for 86Rb substantially increased in the organs of the splanchic area and in the lungs.
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Explore the source record for details and available documents.