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Biomedical subjects

M A Novikov

Publications and source records attributed to M A Novikov.

9 recordsLinked to original sources
PubMed1997

[On-board equipment-based study of psycho-physiological and biochemical responses dynamics of operators during 135-day isolation in the "Mir" orbital station phantom].

There present the investigative findings of the dynamics of psycho-physiological and biomedical responses of the test subjects during simulated emergencies at different stages of adaptation to 135-day isolation in the Mir orbital station mock-up. Ehe main operating factor of an emergency was the 2-day sleep deprivation in combination with the continuous complex and intensive operator work which included the elements of the professional activity of the cosmonauts, among them the simulation of the regular and emergency docking of the spacecraft. By and large the observed physiological responses were characterized by moderate degree of manifestation, they were of functional character and were adequate for the investigated experimental conditions. The impaired quality of performing the applied psychophysiological tests and what is especially important the operations simulating the cosmonauts, professional activity in the extreme emergency conditions is noteworthy. Judging from some indicators the manifestation was dictated by the duration of operator isolation in the Mir orbital station mock-up and by the duration of a contingency simulation. In the degree of manifestation and in the time of development some changes in the state and working capacity of the operators were characterized by the individual differences.

Adaptation, Physiological↗
PubMed1996

Group dynamics and crew interaction during isolation.

The Homeostat test system was used to determine the interaction effectiveness of the chamber crew during isolation. The group had a complex and unique structure, reflected in the fact that all four subjects expressed considerable leadership activity. The course of the Homeostat task solution parameters testifies to the formation of an intergroup communicative net, which was not completed. This phenomenon was accompanied by emotional tension in the group. The individual contributions to the interaction were investigated. The crew represents a small group with a complex communicative structure. This was due to the presence of above normal leadership activity in all four crew members. The complex course of the leadership activity parameter and the presence of elements of group management allow us to label the crew as a complementary group, which is capable of coping with a wide range of tasks in problem situations. At the same time, the complex group structure caused a certain level of emotional tension in the group. This tension was drained to the outside world by conflicts with the project management. Subjects B and H played a positive role in the reduction of intergroup tension.

Astronauts↗
PubMed1990

[Study of the antigenic structure of hepatitis B virus proteins. I. Synthesis of pre-S fragments of hepatitis B virus proteins and their immunogenicity].

Fragments of hepatitis B virus envelope proteins corresponding to the parts of the pre-S domain were synthesised and immobilized on the carriers with low own immunogenicity. The highest stimulation of the antibody production was observed for the antigens immobilized on microspherical carriers or gelatin modified by H-Gly-Tyr-OH. Among peptides used for immunization, pre-S fragment 134-144, conjugated with microspherical carrier, proved to be the most active.

Amino Acid Sequence↗
PubMedDate not supplied

[Transabiotic factors in an aqueous environment (a review)].

Excretion of metabolites is a characteristic feature of any alive organism. A big group of these products--second metabolites--because of their variability, quantity and physico-biological activity have a special importance in aquatic environment. Exometabolites of some organisms become an important part of environment for the others. The authors discussed the origin and evolution of exometabolites from simple waste products to biologically active substances. Quantitative and qualitative aspects of metabolic excretion by organisms in water conditions are analysed. The data on composition, origin and biological function of some second metabolites of different groups of aquatic organisms are presented. The authors propose a classification of second metabolites according to their functional significance. The role of metabolites and decay products in the development of chemical information streams in hydrobiocoenosis is analysed. Metabolites (soluble organic substances) form a field of chemical information for biotic community. The most important functions of this field are communication and conditioning. The authors emphasize the importance of investigations of chemical bioinformation field in aquatic ecosystems.

Animal Communication↗
PubMedDate not supplied

[Psychophysiological selection: status and prospects].

The major stages in the development of psychophysiological selection of cosmonauts in the USSR are discussed. The psychophysiological selection was originally based on the data of psychoneurological expertise of the flight personnel and achievements of aviation psychology in the USSR. This was followed by the development of psychophysiological research, using instrumentation and simulation flights. Further complication of flight programs and participation of non-pilot cosmonauts (engineers, scientists) necessitated detailed study of personality properties and application of personality tests. At the present stage in the development of psychophysiological selection great importance is attached to the biorhythmological selection and methods for studying man's capabilities to control his own emotional, behavioral and autonomic reactions as well as environmental parameters. The review also discusses in detail methods of group selection and problems of rational selection of space crews.

Behavior↗