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Biomedical subjects

M A Menser

Publications and source records attributed to M A Menser.

At least 37 records · Page 2Linked to original sources

Childhood immunization 1979. Disturbing statistics for metropolitan Sydney.

Twenty-seven per cent of children (24 out of 90) born consecutively in an inner-city hospital had not completed their primary courses of immunization at the end of the first year of life. Many of the parents of these children had no knowledge of how many doses of vaccine their children required. When 578 schoolchildren aged 12 years were studied, only 40% of these were found to be immune to all three poliovirus serotypes and 12% were not immune to diphtheria. The proportion of children who were not immune to diphtheria varied greatly, and was 24% in one school. The reasons for these low levels of immunity are discussed, and several recommendations are made. It is suggested that a standard immunization record card or book be adopted throughout Australia, and that this card be issued to the newborn child. It is also suggested that consideration be given to the introduction of laws which require that evidence of immunization (or certification of exemption from immunization) be presented at the time of school entry. In the meantime, mopping-up programmes should be conducted in schools where herd immunity is low and a poliomyelitis vaccine (Sabin) booster should be recommended for all children at the age of 12 years.

Australia↗

Rubella vaccination in Australia: 1. A five-year follow-up of vaccinated schoolgirls.

Schoolgirl rubella vaccination commenced in New South Wales in 1971. Serological follow up of 242 girls, four to five years after vaccination, showed that 9% of girls had missed the vaccination programme. Only 5% of vaccinees were still susceptible to rubella in comparison with 27% of unvaccinated male controls. The efficacy of the programme is thus well demonstrated. Screening for vaccine failures at the time of prescribing contraceptives is suggested as a means of detecting schoolgirl vaccine failures. It is noted that the first cohort of schoolgirl vaccinees has not yet reached the peak childbearing age range.

Adolescent↗

Rubella vaccination in Australia: 2. Experience with the RA27/3 rubella vaccine and results of a double-blind trial in schoolgirls.

RA27/3 rubella vaccine (Almevax) was used for the first time in Australia. The seroconversion rate was similar to that seen with Cendehill vaccine (Cedevax), but there were fewer subjects with low antibody titres after Almevax vaccine. Although Almevax vaccine was associated with a significantly higher incidence of sore throat, rash and joint involvement in seronegative adults, the incidence of side effects in a double-blind trial in schoolgirls was similar for the two vaccines, and the morbidity was low in both groups. Almevax vaccination successfully boosted low antibody titres in 11 of 14 women who had previously responded poorly to Cendevax vaccination. It would be difficult to differentiate the better vaccine for the schoolgirl programme. In some clinical situations, however, one vaccine has advantages over the other.

Adolescent↗

Rubella infection and diabetes mellitus.

The incidence of diabetes mellitus was increased in patients with congenital rubella. Experimental congenital rubella infection in rabbits caused histological changes in the beta-cells of the pancreatic islets similar to those found in mice made diabetic by the M variant of the encephalomyocarditis virus. It is concluded that the diabetes seen in congenital rubella is due to viral infection of the pancreatic islet cells.

Adult↗

HL-A antigens in congenital rubella and the role of antigens 1 and 8 in the epidemiology of natural rubella.

Study of 87 patients (53 adults, 23 males; 34 children, 18 males) with congenital rubella revealed an increased incidence of several HL-A antigens, including HL-A5, HL-A1, HL-A3 and HL-A8, the frequency of HL-A1 being raised because of the statistically significant increase of this antigen in the adult female subjects compared with normal controls. Correlation of the level of seropositivity to rubella virus in 29 normal adult populations, according to racial origin and geographic location, with the frequency of various HL-A antigens revealed the most significant association with HL-A1 (r equals 0.71). It is suggested that the presence on the cell surface of HL-A1 or the combination of HL-A1 and 8 may fovour rubella virus infection.

Adult↗

Dermatoglyphics in children with acute leukaemia.

The dermatoglyphics of 135 children with acute leukaemia differed significantly from those of normal controls, and examination of 174 of the patients' first degree relatives indicated that familial factors were involved. The findings suggested that within the racial group studied dermatoglyphics may partly identify a population subgroup which is at increased risk of leukaemogenesis. While these observations may not have immediate clinical application, they are likely to contribute to a greater understanding of individuals who have increased constitutional susceptibility to leukaemia.

Acute Disease↗