Biomedical subjects
M A Mascola
Publications and source records attributed to M A Mascola.
Exposure of young infants to environmental tobacco smoke: breast-feeding among smoking mothers.
OBJECTIVES: This study examined the degree to which breast-feeding and cigarette smoking by mothers and smoking by other household members contribute to the exposure of infants to the products of tobacco smoke. METHODS: The subjects were 330 mother-infant pairs derived from a cohort of 1000 pairs enrolled in a longitudinal study of the pulmonary effects of prenatal and postnatal smoking. The main outcome measure was corrected urinary cotinine levels. RESULTS: Urinary cotinine levels were 10-fold higher in breast-fed infants of smoking mothers than among bottle-fed infants of smoking mothers. Among infants of nonsmoking mothers, urine cotinine levels were significantly increased in infants living in homes with other smokers; in this group there was no significant difference between bottle-fed and breast-fed infants. Infants whose mothers smoked in the same room as the infant had only nonsignificant increases in cotinine levels compared with infants whose mothers restricted their smoking to other rooms. CONCLUSIONS: Breast-fed infants of smoking mothers have urine cotinine levels 10-fold higher than bottle-fed infants whose mothers smoke, suggesting that breast-feeding, rather than direct inhalation of environmental tobacco smoke, is the primary determinant of cotinine levels in infants whose mothers smoke.
Obstetric management of the high-risk lupus pregnancy.
With improvements in diagnosis and treatment, the prognosis of patients with systemic lupus erythematosus has generally improved in recent years, and similarly the outlook for women who become pregnant in the setting of this disorder is far more optimistic than it once was. The risk of significant morbidity to both the mother and fetus exists, however. Beginning with preconception counseling, a careful and thorough approach to the care of the patient and cooperation among her various health care providers optimizes the chance of a successful pregnancy.