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Biomedical subjects

M A Mansell

Publications and source records attributed to M A Mansell.

65 records · Page 4Linked to original sources
PubMed1982

The effect of hyperacetatemia on cardiac output during regular hemodialysis.

We used impedance cardiography to monitor changes in cardiac output in 22 adult patients with terminal renal failure during hemodialysis against a dialyzate containing acetate. In 7 patients arterial acetate levels rose progressively during dialysis while in the remainder they remained low and steady. Patients who developed hyperacetatemia were able to maintain an elevated cardiac output during dialysis in contrast to the patients with stable acetate levels in whom cardiac output fell. These results strengthen our previous conclusion that acetate as used in conventional regular hemodialysis does not have a cardiodepressant action. The reported benefits of bicarbonate dialysis therefore involve other factors.

Acetates↗
PubMed1981

Leucocyte ATP and renal failure.

1. We have measured adenosine 5'-triphosphate (ATP) levels in isolated leucocyte suspensions from patients with renal failure. 2. Leucocyte ATP is reduced in these patients, unlike erythrocyte ATP which is known to be elevated in uraemia. 3. The relevance of reduced leucocyte ATP to the abnormalities of cation transport and cell function which occur in uraemia is discussed.

Acute Kidney Injury↗
PubMed1981

Effect of renal failure on erythrocyte purine nucleotide, nucleoside and base concentrations and some related enzyme activities.

1. We have studied purine metabolism in renal failure using high-pressure liquid chromatography to determine metabolite concentrations in erythrocytes and plasma, and microradiochemical assays of enzyme activity in erythrocytes. 2. The mean activities of some of the enzymes involved in purine metabolism were raised in renal failure. Significant elevations of adenylate kinase (EC 2.7.4.3), purine nucleoside phosphorylase (EC 2.4.2.1), hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) and adenosine deaminase (EC 3.5.4.4) but not of adenine phosphoribosyltransferase (EC 2.4.2.7) and ribosephosphate pyrophosphokinase (phosphoribosylpyrophosphate synthetase; EC 2.7.6.1) activities were demonstrated. However, there was an overlap between results from patients with renal failure and normal (control) subjects. Erythrocyte phosphoribosylpyrophosphate levels were also unchanged. 3. Erythrocyte nucleotide concentrations especially those of inosine were raised in renal failure. 4. The plasma inosine was reduced in renal failure. 5. The significance of these changes is discussed.

Adolescent↗
PubMed1980

Retroperitoneal fibrosis and scleroderma.

The association of retroperitoneal fibrosis and systemic sclerosis is reported from a patient positive for the HLA-B27 antigen. This appears to be the first report of such an association. Pathological features common to the 2 syndromes are discussed and the literature is reviewed.

Female↗
PubMed1980

Black urine.

A patient is described in whom spontaneous blackening of the urine, due to melanin formation, resulted from treatment with alpha-methyldopa. The colour change became apparent only after the correction of a severe postoperative hyponatraemic alkalosis, the urinary pH had become alkaline, as melanin formation in acid urine is very slow.

Female↗
PubMed1979

Incidence and significance of rising blood acetate levels during hemodialysis.

Recent work suggests that rising arterial acetate levels occur in some patients undergoing hemodialysis and that they may be responsible for some dialysis problems, particularly cardiovascular instability. Blood acetate levels and acetate flux rates have been determined in 20 adult and 4 pediatric patients during hemodialysis as well as in 4 patients with combined renal and hepatic failure. Rising acetate levels occurred in 25% of the adult patients, although they were stable in the children and the patients with renal and hepatic failure. The occurrence of hypotension during dialysis was unrelated to a high blood acetate level.

Acetates↗
PubMed1978

N-acetyl-beta-D-glucosaminidase: A new approach to the screening of hypertensive patients for renal disease.

Urinary activity of the enzyme, N-acetyl-beta-D-glucosaminidase (N.A.G.) was examined as a screening test for renal disease in patients with hypertension. Renal disease was present in 64% of patients with increased N.A.G., compared with only 14% of patients with normal N.A.G. The measurement of N.A.G. is cheap and convenient and this simple test warrants further assessment in hypertension as a guide to the need for further investigation.

Acetylglucosamine↗
PubMed1978

Measurement of acetate in aqueous solutions and plasma by gas phase chromatography using a porous polymer stationary phase.

A method of acetate determination by gas phase chromatography using a porous polymer stationary phase is reported that is suitable for use with aqueous and plasma samples. It is linear up to 100 mmol/l and has a coefficient of variation of less than 4% for acetate values of greater than 1 mmol/l. The recovery of acetate from plasma is 92% and sample retention time is 3 minutes. The reference range of plasma acetate in a group of 40 apparently healthy subjects was from less than 0.1 to 0.35 mmol/l. The frequently encountered problem of absorption and ghosting of volatile fatty acids is overcome without the addition of formic acid vapour to the carrier gas.

Acetates↗