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Biomedical subjects

M A LEON

Publications and source records attributed to M A LEON.

At least 19 recordsLinked to original sources
PubMed1965

COMPLEMENT: INACTIVATION OF SECOND COMPONENT BY P-HYDROXYMERCURIBENZOATE.

p-Hydroxymercuribenzoate inactivates the second component of complement whether it is in solution or is fixed to a sensitized erythrocyte together with the first and fourth components. Inactivation by the drug is blocked but not reversed by cysteine. Partial purification of the second component of complement is described.

Benzoates↗
PubMed1957

Quantitative studies on the properdin-complement system. II. Kinetics of the reaction between properdin and zymosan.

The reaction of human, bovine, and pig properdin with excess zymosan exhibits an induction period followed by a rapidly accelerating formation of the properdin-zymosan (PZ) complex. Two methods for determining the quantity of PZ complex are given, one using human serum lacking properdin, the other using a fraction of pig serum containing complement components, C'1, C'3 and C'4.

Animals↗
PubMed1956

Quantitative studies on the properdin-complement system.

Quantitative methods have been developed for the estimation of C'3 and properdin. With these methods, the kinetics of the over-all reaction between properdin, zymosan, and C'3 were investigated. The reaction followed first order kinetics, provided zymosan was in excess, and the serum not diluted beyond 1/4. The reaction rate was proportional to the temperature, and an activation energy of 20,500 calories/mole was found. The distinction between total properdin and available serum properdin is discussed.

Complement System Proteins↗