Teratoepidemiology.
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Abnormalities, Drug-Induced↗
Biomedical subjects
M A Klingberg
Publications and source records attributed to M A Klingberg.
Influenza surveillance in Israel, 1976--77.
An influenza surveillance program developed and conducted in three districts in Israel during winter 1976--77, was based mainly on morbidity data in the general population, corroborated by sero-epidemiologic surveys on selected groups. This information was supplemented by data on mortality organized according to specific age groups. During the period under study, similar results were observed in each of the three districts surveyed. Two successive waves of influenza were recorded: an early wave due to B/Hong Kong/5/72 followed by an A/Victoria/3/75 outbreak. Both waves were of moderate extent, with the highest frequency of clinical influenza occurring in the youngest group, age 0--14 years. The age-specific mortality rates were highest and rather similar in the extreme age groups 65+ and 0. The search of A/New Jersey/8/76 antibody revealed a considerable proportion of positives with a higher titer in the older age groups. A special serologic survey among Yemenite Jews over 50 years of age, who immigrated to Israel in 1949, showed that the 1918 influenza pandemic also reached that isolated country. The surveillance program provided an early warning system as well as a rather accurate measurement of influenza impact in Israel.
Adolescent↗
Influenza immunization: serologic and clinical responses in military units.
Two inactivated influenza-virus vaccines were tested and compared in three army training units in Israel. The serological responses to the vaccines and the side-effects were assessed. The vaccines contained the influenza strains which were prevalent in 1974: A2/Port Chalmers/1/73 and B/Hong Kong/8/73. One of the vaccines also contained A2/England/42/72. Both vaccines caused a more than three-fold rise in geometric mean titers against influenza A strains, and about a twofold rise in geometric mean titers against influenza B/Hong Kong/5/73. Approximately 75%-80% of the vaccinees acquired protective hemagglutination-inhibition antibody titers against influenza A strains, while less than 30% acquired protective titers against B strains. In general, there were no significant differences between the serological responses to the two vaccines. More than 50% of the vaccinees experienced at least one systemic side-effect (50.3% with one vaccine and 61.0% with the other). The average number of side-effects per person was between 1.78 and 2.11. However, these side-effects were generally of short duration and caused minimal disability. On the whole, the two vaccines did not differ significantly with regard to the side-effects they caused.
Antibody Formation↗
Letter: Rising rates of congenital dislocation of the hip?
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Hip Dislocation, Congenital↗
Letter: Rising rates of congenital dislocation of the hip?
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Hip Dislocation, Congenital↗
Letter: Rising rates of congenital dislocation of the hip.
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Hip Dislocation, Congenital↗
[Epidemiological findings in the study of congenital malformations].
Experience with thalidomide and German measles contracted during pregnancy has focused attention on the question of birth defects. It is suggested that good reasons exist for the carrying out epidemiological investigations to establish the true incidence and geographical and social distribution of such deformities, and hence their possibly "environmental" origin at least in some instances. Such investigations would supplement research into experimental teratology. The advantages, disadvantages and limitations of retrospective and prospective investigations are discussed. A detailed account is given of a prospective survey in progress in Israel. Reference is also made to a similar survey being launched in some Italian cities with the aid of the CNR.
Abnormalities, Drug-Induced↗
Monitoring of influenza in Israel 1976/77.
The main objectives of the monitoring were: (1) to define the prevalent virus involved in influenza activity: (2) to determine the time of its occurrence; and (3) to evaluate its extent and impact. A sudden rise in the frequency of visits associated with acute respiratory conditions in the age group 0-14 to the emergency rooms of 14 hospitals throughout the country, correlated well with the start of influenza B/Hong Kong activity; this was simultaneously attested by two different laboratories. The later and sporadic occurrence of influenza A/Victoria activity did not affect the usual trend observed in the frequency of visits to emergency rooms. An age group stratified serologic follow-up pointed to a progressively increasing rate of influenza B infection up to the age group 15-24. A crude morbidity rate of 13-18% was recorded during influenza B outbreaks in several agricultural settlements. The percentage distribution of cases was about 15,21, 26 and 37 in the age groups 0-4, 5-9, 10-14 and 15+, respectively. The mortality associated with influenza B and influenza A activity did not exceed the expected rate.
Adolescent↗