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Biomedical subjects

M A Khatamee

Publications and source records attributed to M A Khatamee.

9 recordsLinked to original sources
PubMed2006

Anencephaly and pregnancy outcome in Iran.

OBJECTIVES: The aim of this research is to study the complications of pregnancy associated with anencephaly. STUDY METHODS: Thirty-five mothers who delivered an anencephalic baby (as a case group) and forty-three mothers who delivered a non-anencephalic baby (as a control group)were included in this analytical research study. All cases and controls had singleton pregnancies. More than one matched control was chosen for each case when possible. The cases were selected by a survey of 149,000 births in six educational centers located in Tehran. The control group matched with the study group regarding birth date, maternal age, socioeconomic status and living environment. The outcomes for the control and study groups were studied and compared in the following areas: premature rupture of membrane, pregnancy length, fetal presentation, hydramnios, fetal death, sex ratio (male to female ratio) and other anomalies. RESULTS: Anencephaly increased the likelihood of premature rupture of membrane by a factor of seven (p < 0.001). Pre-term birth was six times more likely (p < 0.005) and acephalic fetal presentation was 46% (p < 0.0005). In the study group, sex ratio was 0.52 and in control was 1.68 (p < 0.025). Further, hydramnios appeared in 90% of the study group. Finally, the general likelihood of any abnormality was 19 times (p < 0.0005) greater in the study group than the control group. CONCLUSIONS: Considering the clear correlation between anencephaly and pregnancy complications, precise prenatal care, early diagnosis and treatment are strongly indicated in order to avoid serious maternal complications.

Adult↗
PubMed1999

A controlled study for gender selection using swim-up separation.

OBJECTIVE: To evaluate the success for gender selection using a sample of semen separated by a modified swim-up technique. DESIGN: We retrospectively compared the gender outcome of two treatments (A and B) for either a male or female offspring with those who conceived spontaneously. SETTING: Private practice of one author (M. A.K.). PATIENTS, PARTICIPANTS: The treatment groups consisted of 52 total pregnancies for couples who conceived by the separation technique. Of these 52 participants, 15 desired a female offspring and were placed into treatment A and 37 desired a male offspring and were placed into treatment B. The control groups consisted of 162 women who were presented with initial consultation for gender selection and conceived spontaneously. Control group A consisted of 80 women who initially chose a female offspring, and control group B consisted of 82 participants who initially chose a male. INTERVENTIONS: In treatment group A, one timed intrauterine insemination (IUI) was carried out with the bottom 0.5 ml of the separated semen on cycle days 12-14, when the follicle was 18-22 mm. Patients in this group were also administered clomiphene citrate and human chorionic gonadotropin. In treatment group B, one timed IUI was done with the top 0.5 ml of the separated semen, when the follicle was 18-22 mm. MAIN OUTCOME MEASURE: The gender outcome of the pregnancies of two treatment and control groups was evaluated based on the known desired gender. RESULTS: The success rate for conceiving a female child after intervention (treatment group A) was 86.7% effective (p = 0.002) as compared to the control group A. Couples seeking a male child (treatment group B) were 89.2% effective (p = 0.0002) as compared to the control group B. CONCLUSIONS: This study reveals that the modified swim-up method with additional monitoring results in statistically significant gender preselection.

Adult↗
PubMed1991

A controlled study for gender selection.

OBJECTIVE: To evaluate the success for gender selection of insemination with a sample of semen separated by a serum albumin density separation gradient. DESIGN: We retrospectively compared the gender outcome of conceptions of couples who conceived spontaneously with those who conceived secondary to an insemination with separated semen. SETTING: Private practice of one author (M.A.K.). PATIENTS, PARTICIPANTS: The study group consisted of 48 pregnancies of couples who conceived by the separation technique. The control group consisted of 46 pregnancies of couples who initially presented for consultation for gender selection but conceived spontaneously. INTERVENTIONS: In the study group, one timed intrauterine insemination with separated semen was performed per cycle, with a mean of 2.3 cycles per couple. Patients desiring a female were also treated with clomiphene citrate and human chorionic gonadotropin. MAIN OUTCOME MEASURE: The gender outcome of the pregnancies of the two groups was evaluated based on the known desired gender. RESULTS: The success rate for conceiving a desired male was 56.5% in the study group and 60.9% in the control group (P = 1.000). Of couples seeking females, 78.6% of the procedure group versus 35.3% of the control group were successful (P = 0.019). CONCLUSIONS: This study debates the albumin gradient as definitively enriching the proportion of Y-bearing sperm after in vitro separation.

Cell Separation↗
PubMed1982

Mycoplasma colonization in primate animal laboratories.

The role of bacterial and protozoal infections in reproductive failure and fetal loss has been difficult to establish in humans. This study was done in 78 female primates to determine if ureaplasma urealyticum was present. The highest overall incidence of positive cultures (36.4%) occurred among the chimpanzees, who also had the highest number of breeders (i.e., sexually active females.) This suggests that the organisms may be transmitted sexually. An opportunity is now available to study the role of ureaplasma urealyticum in reproductive problems, to determine the exact nature of its pathogenicity.

Animals↗
PubMedDate not supplied

Clinicopathologic diagnosis of mycoplasma endometritis.

Chronic endometritis and its association with cervical colonization by Ureaplasma urealyticum was investigated in a group of 28 infertile patients treated for infertility problems. Twenty had positive cervical cultures for U. urealyticum and eight had negative cultures. There was focal chronic endometritis in 11 of the endometrial biopsies of the 20 cases with positive mycoplasma cultures. Ten of these biopsies were in the secretory phase, and one was in proliferative phase. No case with a negative culture showed endometritis.

Biopsy↗
PubMedDate not supplied

Sex preselection in New York City: who chooses which sex and why.

With its increasing success, sex preselection has become a matter of general concern, and interest in it is growing. Three aspects of sex preselection in New York City were considered. Who is choosing the sex? Which sex is being chosen? Why have the choices been made? In this investigation, 178 couples were studied and all 57 non-American couples chose boys; however, 120 American couples chose boys and girls with equal frequency depending upon the gender of the children at home. Non-American couples chose boys for economic and business reasons (40%), cultural reasons (30%), and personal reasons (30%). Sex preselection is valuable in preventing sex-linked genetic disorders. Many are fearful of a sudden change in sex ratios should sex preselection be successfully and inexpensively carried out.

Cultural Diversity↗
PubMedDate not supplied

Infertility: a preventable epidemic?

Infertility with a broad etiological background has only been treated, but not prevented. With the exception of ovulation induction, the success rate of pregnancy in most cases has been rather dismal in view of the high socioeconomic burden. A questionnaire survey of the cost of infertility investigation and treatment has been undertaken, and it has been estimated that the cost of infertility due to the sequelae of sexually transmitted diseases ranges in the vicinity of $64 billion, which is to be compared with the prevention cost of $335,000. Recommendations on preventative aspects are discussed.

Female↗