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Biomedical subjects

M A Kaufman

Publications and source records attributed to M A Kaufman.

At least 19 recordsLinked to original sources
PubMed1990

Effect of epinephrine on intrathecal fentanyl analgesia in patients undergoing postpartum tubal ligation.

Eighty women receiving spinal anesthesia for postpartum tubal ligation were entered into a double-blind, randomized protocol studying the effects of epinephrine on intrathecal fentanyl-induced postoperative analgesia. All patients received 70 mg hyperbaric lidocaine with either 0.2 mg epinephrine (LE), 10 micrograms fentanyl (LF), epinephrine and fentanyl (LFE), or 0.4 ml saline (L). Onset and regression of anesthesia, degree of intraoperative comfort, incidence of pruritus, and extent of postoperative analgesia were evaluated. The simultaneous administration of epinephrine and fentanyl prolonged the duration of complete analgesia (137 +/- 47 min (LFE); 76 +/- 32 min (LE); 85 +/- 44 min (LF); 65 +/- 36 min (L)) and the duration of effective analgesia (562 +/- 504 min (LFE); 227 +/- 201 min (LE); 203 +/- 178 min (LF); 198 +/- 342 min (L)). Administration of epinephrine decreased the incidence of pruritus associated with intrathecal fentanyl (1/18 (LFE); 1/21 (LE); 8/19 (LF); 2/19 (L)).

Adult↗
PubMed1987

Young adult-form of dementia with neurofibrillary changes and Lewy bodies.

Alzheimer's neurofibrillary tangles, Lewy bodies and chromatolytic neurons were found in the brain at autopsy of a 28-year-old male with pyramidal and extrapyramidal signs, and severe dementia of 7-year duration prior to his death. Review of histological material showed generalized changes involving both cortical and subcortical structures. These changes were characterized by the presence of neurofibrillary myelin in long tracts and in subcortical regions. The neurofibrillary tangles were mostly composed of Alzheimer's paired helical filaments (PHF), PHF were immunostained with both polyclonal and monoclonal antibodies to PHF and the microtubule-associated protein tau. Some Lewy bodies were immunolabelled with monoclonal antibodies to PHF. To the best of our knowledge it is the first reported case of a young adult-form of dementia with extensive formation of neurofibrillary changes and Lewy bodies.

Adult↗
PubMed1972

Neuropathology.

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Animals↗
PubMed1971

Neuropathology.

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Abnormalities, Multiple↗
PubMed1970

Neuropathology.

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Brain Injuries↗
PubMed1969

Neuropathology.

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Animals↗
PubMed1968

Neuropathology.

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Adolescent↗
PubMed1966

Neuropathology.

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Animals↗
PubMed1965

Neuropathology.

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Animals↗
PubMedDate not supplied

Cochlear summating potential to broadband clicks detected from the human external auditory meatus. A study of subjects with normal hearing for age.

The cochlear summating potential (SP) preceding the auditory nerve compound action potential (AP) was elicited by broadband alternating condensation and rarefaction clicks and recorded by noninvasive electrodes from the external auditory meatus (EAM) of 60 volunteers of both sexes, 12 to 67 years old, who had normal hearing for age. Quantitative data were obtained on: the number of ears displaying measurable SPs; the SP detection level; the SP onset, peak and rise times; the duration of the SP-AP complex; the SP amplitude; and the SP/AP amplitude ratio. Previously unknown relationships were unveiled between the amplitude, but not the temporal, measures of the SP and laterality, sex, age, and audiometrically determined hearing thresholds to 4 to 8 kHz tones. The highest correlations were obtained with these last thresholds, which suggested that receptors in the basal turn of the cochlea played a dominant role in the generation of the EAM-detected SP. To improve on existing techniques for determining abnormal SP elevation, a multiple regression method was devised that utilized sex, age, 4 to 8 kHz hearing thresholds, and AP voltage to establish upper normal limits of SP amplitude for individual subjects and ears.

Acoustic Stimulation↗
PubMedDate not supplied

An unusual intracerebral connective tissue mass.

A sharply circumscribed, vascular, connective tissue mass which replaced the cortex of several adjoining cerebral gyri is described. The histology of the lesion differs from that of previously reported central nervous system maldevelopments and neoplasms. However, there are a number of similarities to the pathology found in late phases of syphilitic "colloid" or "hyaline" degeneration of the brain.

Brain Diseases↗