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Biomedical subjects

M A Hall

Publications and source records attributed to M A Hall.

At least 145 records · Page 8Linked to original sources
PubMed1981

Morphea-like reaction to D-penicillamine therapy.

We report the case of a 48-year-old woman who developed morphea-like plaques after 1 year of treatment with D-penicillamine at 250 mg daily for a seronegative erosive arthritis of rheumatoid type. The rash began as several red itchy patches on the trunk; these became thickened and shiny over about 3 months. The histological appearance was of increased dermal fibrosis with an inflammatory infiltrate round dermal capillaries. However, epidermal changes were not typical of morphea. New lesions ceased to appear within a few months of stopping penicillamine, and by 1 year all the plaques were pale and symptomless.

Adult↗
PubMed1979

Spinal mobility in the adolescent.

The ranges of spinal movement in 390 healthy children aged from 10 to 15 years have been recorded. These measurements are in two planes, anterior and lateral; they are quick and easy to perform and require no special equipment, just a tape measure. Many conditions occurring in childhood can lead to limitation of spinal movement: these include juvenile ankylosing spondylitis, spondylolisthesis, Scheuermann's vertebral osteochondritis, discitis and vertebral fractures, the latter being not uncommon in children receiving prolonged corticosteroid therapy. The purpose of the present paper is to define the normal range for anterior and lateral spinal flexion in adolescents and to correlate these with sex, age, height and weight.

Adolescent↗
PubMed1977

The intracellular reserve polysaccharide of Clostridium pasteurianum.

An amylopectinlike polysaccharide (granulose) was the only glucan produced in significant quantities by six wild-type strains of Clostridium pasteurianum grown in glucose minimal medium. The intracellular polysaccharide granules laid down before sporulation contained only this amylopectin. No intracellular dextran was discovered in these wild-type strains, nor in a granulose-negative mutant strain of C. pasteurianum possessing an ADP glucose pyrophosphorylase (EC2.7.7.27) but lacking a granulose synthase (i.e. ADP glucose-alpha-1,4-glucan glucosyl transferase, EC2.4.1.21). Furthermore, methylation analysis demonstrated that (1 leads to 6) linked alpha-D-glucose units accounted for less than 2% of the entire glucose content of these organisms.

Amylopectin↗
PubMed1977

Reserpine-induced supersensitivity to the activation of cardiac glycogen phosphorylase by calcium.

Rats receiving reserpine (2.5 mg/kg, 24 h before sacrifice) developed a supersensitivity to the phosphorylase activating effect of both noradrenaline and Ca2+. Supersensitivity to the inotropic and chronotropic effects of the agonists did not develop with this dose of reserpine. It is concluded that reserpine induced supersensitivity, as well as being dose and species dependent, is also dependent on the response measured. It is concluded further that the supersensitivity developed to noradrenaline may be due to an alteration in the responding system (in this case the phosphorylase activating system) to calcium.

Animals↗
PubMed1977

Juvenile chronic polyarthritis: clinical sub-groups and response to medication.

Juvenile ankylosing spondylitis, as a clinical entity, is outlined. A double-blind trial compared Safapryn and Butazolidin, each given for 3 months, for 15 treatment periods in 11 patients. No differences were shown, but the study highlighted the problems of assessing this condition, and some comments are made, hopefully, to guide further investigators in this field.

Acetaminophen↗
PubMed1972

Back pain and car-seat comfort.

A brief survey of the incidence of back trouble among the members of the Consumers' Association's car test unit led on to a survey of differences in the way those with and those without back trouble rated the comfort of car seats. The methods are described in some detail. It is suggested that people with back trouble may be a useful test tool for designers. It is concluded that car seats should cater for a wider range of a driver size, and should allow individual drivers to adjust the amount of support given to different areas of the body.

Journal Article↗