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Biomedical subjects

M A Grundy

Publications and source records attributed to M A Grundy.

3 recordsLinked to original sources

Transport and harvesting of suspended particles using modulated ultrasound.

Polystyrene particles of 9 microns diameter were acoustically concentrated along the axis of a water-filled cylindrical waveguide containing a 3 MHz standing wave field. Modulation of the acoustic field enabled transport of the concentrated particles in the axial direction. Four modulations were investigated: 1, a fixed frequency difference introduced between two transducers; 2, ramping the transducer frequency; 3, tone burst, i.e. sound that is pulsed on and off, allowing intermittent sedimentation under gravity; and 4, switching the sound off to allow continuous sedimentation. The most efficient transport (leaving the fewest particles in suspension) of clumps to one end of the container was achieved with method 1 above. In this system the maximum speed of transport of the axial clumps was 24 mm s-1. A theory developed here for the transport of particles in a pseudo (i.e. slowly moving) standing wave field predicts an upper limit, which increases with particle size, for the speed of an entrained body. For a single 9 microns diameter particle in a field with a spatial peak pressure amplitude of 0.4 MPa this speed would be 0.5 mm s-1. The higher experimental speeds observed here emphasize the value of acoustically concentrating particles into relatively large clumps prior to initiating transport.

Acoustics

Microbial content of aerosols produced from suspensions exposed to megahertz frequency ultrasound.

A piezo-electric bowl transducer was used to generate aerosols by focusing ultrasound in the frequency range 1-7 MHz at a liquid/air interface. Atomization at the liquid surface and the production of a fountain contributed to aerosol formation. When the liquid consisted of suspensions of representatives from the viral, bacterial, and yeast groups of micro-organisms (covering a 0.2-11.5 microns size range) living organisms were isolated from the aerosols at all frequencies. The fountains were implicated as a major source of air-borne micro-organisms because significant numbers of isolates were obtained in the presence of fountains but in the absence of obvious atomization, and theoretical predictions make the sizes of droplets arising from atomization at the higher frequencies too small to have carried some of the larger organisms.

Aerosols