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Biomedical subjects

M A Gonchar

Publications and source records attributed to M A Gonchar.

At least 19 recordsLinked to original sources
PubMed2003

[Comparative efficacy of betaserc and cinnarizine of vertigo in patients with migraine].

Headache and vertigo often emerge simultaneously. Fifty six (40%) out of 140 patients complaining of vertigo were studied. Emerging in the aura and/or in headache phases, vertigo was more frequently registered in patients suffered from migraine with aura (57%). Vertigo associated with migraine was diagnosed in 25% of the cases. The patients were randomized into 2 equal identical groups, one of which was treated by betaserc (16 mg, 3 times daily before meal) and the other one was given cinnarizine (25 mg, 3 times daily). Treatment duration was 12 weeks. Reduction of vertigo attacks frequency and headache by 50% and over, in comparison to the baseline period, was considered as beneficial. Fifty three (95%) patients completed the treatment course. Decrease of a risk for negative results and a frequency of positive effect of vertigo therapy were significantly higher in the group receiving betaserc. Reduction of monthly relapses by 50% and over was detected in 79% of the patients of betaserc group and in 52% of those of cinnarizine one. Migraine attacks monthly frequency was diminished by 43% and 64%, respectively. Therefore, betaserc is considered for using as vertigolytic medication and for migraine attacks prevention.

Adult↗
PubMed2000

[A comparative efficiency of amitriptyline, fluoxetine and maprotiline in prevention of migraine in attack-free period].

To reduce frequency and severity of the attacks, migraine was treated preventively between the attacks. The most effective drugs were beta-blockers and antidepressants. In a single-blind study we estimated comparative efficiency of amitriptiline (inhibitor of noradrenaline and serotonin reuptake and 5-HT2-receptor antagonist) 12.5-25 mg/daily, fluoxetine (a selective serotonin reuptake inhibitor) 10-20 mg/daily, and maprotiline (a selective noradrenaline reuptake inhibitor) 10-25 mg/daily. The duration of the therapy of migraine between the attacks was 12 weeks. Each group included 20 patients. 46 patients completed the whole course of therapy: 14 patients received amitriptyline, 16 patients--fluoxetine, and 16 patients--maprotiline. Positive results of the treatment (a reduction of the frequency of the migraine attacks during a treatment by 50% as compared with the baseline period) were observed in 71% of the patients treated with amitriptyline, in 56% of the patients treated with fluoxetine, and in 38% of the patients treated with maprotiline. All the drugs were able to reduce both intensity and duration of a headache. Index of the Quality of Life in the patients with migraine was increased in the groups treated with either amitriptyline or fluoxetine, but not in a group treated with maprotiline. The results obtained agree with the notion about high efficiency of antidepressants given between migraine attacks. Amitriptyline and fluoxetine were more efficient in preventive therapy than maprotiline. These findings suggested indirectly, that the efficiency of antidepressants in treatment of migraine is explained by inhibition of serotonin reuptake and by 5-HT2-receptor antagonism, while influence on the inhibition of noradrenaline reuptake was not so significant.

Acute Disease↗
PubMed1986

[Treatment tactics for diseases of the scrotal organs in children].

An analysis of results of treatment of 163 children with acute diseases of the scrotum organs for five years has been made. The authors consider that urgent surgery for acute diseases parallel with establishing more precise localization of the process is a good pathogenetic treatment, prevents the appearance of disturbances of all the testicle functions, first of all the spermatogenic function, excludes an obliteration of the deferent duct, considerably shortens staying at the hospital and is not followed by complications.

Acute Disease↗
PubMed1983

[Blood coagulation disorder during the combined treatment of testicular tumor patients].

The mechanism of hemocoagulation before, during and after combined therapy was studied in 47 cases of testicular tumor. Thrombophilia was suggested by the basal level of hemocoagulation. All patients received a course of combined therapy which included surgery, telegammatherapy and polychemotherapy. In the course of treatment, all patients revealed a decrease in the coagulative properties of blood which manifested itself in hemorrhages in 7 cases. After therapy, blood coagulation indexes did not vary much from normal. This is believed by the authors to be an indication of the efficacy of the treatment.

Adolescent↗
PubMed1983

[Mechanism of development of fatal pulmonary artery thromboembolism during the treatment of kidney and bladder cancer].

Retrospective evaluation of the state of hemostasis in 20 patients dying with pulmonary artery thromboembolism (PATE) after combined treatment of renal carcinoma (10) and urinary bladder carcinoma (10) was performed. The signs of intravascular blood coagulation (IVBC) in the initial condition were determined in all the patients. After a course of pre-operation actin therapy with large fractions (totally 20 g) activation of IVBC was observed both in renal and urinary bladder carcinoma. In the postoperation period, on the day of PATE development in patients with renal carcinoma the state of hemostasis corresponded to stage I of disseminated intravascular coagulation syndrome. In patients with urinary bladder carcinoma after operation the state of hemostasis corresponded to stage II of DIVC-syndrome with signs of local hemorrhage of the urinary bladder wound. The therapy of this condition with fibrinolysis inhibitors (aminocaproic acid) with hemotransfusion without heparin facilitated thrombus formation in these patients in deep pelvic veins followed by PATE.

Adult↗
PubMedDate not supplied

[The pathogenesis and results of the surgical treatment of stress urinary incontinence in women].

The paper presents the incidence rate (3-19.6%) of stress-induced enuresis (SIE) in females. The impact of birth injuries, obstetric instrumentation and heavy physical work resulting in the impairments of the sphincter-detrusor system of the bladder and the musculature of the pelvic bottom on the pathogenesis of SIE is indicated. As a result the bottom of the bladder, the posterior walls of the neck and urethra moved backward to form an obtuse angle with an anterior wall of the urethra that was roentgenologically evidenced as vesiculation. In this line the angle between the anterior and posterior walls of the urethra and neck became more obtuse with no contact upon contractility of their muscles which caused the stress-induced escape of urine. To eliminate vesiculation and enuresis, the authors used successfully the technique of urethral angulation by the duplication formed by the anterior vaginal wall over the cervix and urethra followed by their fixation to the posterior surface of the pubic area on one side and free skin graft on the other. Hebell-Schteckel's technique was a prototype for the method proposed. A total of 156 females with stages II and III SIE were successfully operated on. The results of 1-15 year follow-ups were good and satisfactory in 97 (89.9%) of 109 females. The relapses were more common in the females who had a repeated delivery or were engaged in heavy physical work as well as in two persons operated on in the menopause.

Adolescent↗