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Biomedical subjects

M A Galin

Publications and source records attributed to M A Galin.

At least 55 records · Page 3Linked to original sources
PubMed1977

Radiation therapy of choroidal melanoma.

During the past 8 years, 32 patients with melanoma of the choroid have been treated with cobalt-60 ophthalmic applicators. Excluding three patients lost to follow-up, 24 patients who have now been observed for at least 3 years after treatment form the subject of this study. Each application but two delivered 8,500 to 10,000 rads to the tumour apex. A second application was performed in large tumours showing a poor response to the initial plaque treatment. The factors affecting results include age of the patient, tumour size, total dose delivered, and dose rate. Three out of seventeen patients with tumour diameters greater than 12 mm died of their disease with pulmonary and/or liver metastasis. Three eyes required enucleation and no residual tumour was found in two specimens. Three patients, average age 76 years, died from causes other than melanoma. An 83 per cent relative survival, excluding the three patients lost to follow-up, compares favourably with enucleation. The low incidence of metastasis after radiotherapy suggests augmentation and/or continuation of the host's immune response. Low energy radiation using Iodine-125, with its unusual protective characteristics is ideal for treatment of choroidal melanoma.

Aged↗
PubMed1977

Further observations on eccentric perilimbal suction cup application.

Absence of an anemic, cystic bleb site, as well as reduced fluorescein fluorescence in this area after transcleral fistulizing surgery, infer failure. One method to create or augment bleb formation in suitable eyes is with the use of eccentric suction. This method creates localized ocular message, mobilizes conjunctiva and episclera, and provides a quantitative measure of bleb function.

Adult↗
PubMed1976

Uveitis and intraocular lenses.

Discs of polymethylmethacrylate containing 0-5 per cent. unpolymerized monomer were heated to create increasing concentrations of unpolymerized fragments up to 3-7 per cent. These fragments were then studied in tissue culture and in the anterior chambers of rabbits. No toxicity was evident in culture nor was there a difference in anterior segment response to the discs containing various concentrations of monomer. It would appear that the inflammatory response after implantation is predominantly mechanical in origin.

Animals↗
PubMed1976

Therapeutic use of inducers of interferon on Herpes simplex keratitis in humans.

The double-stranded RNA interferon inducer polyinosinic-polycytidylic acid (In-Cn) was used to treat acute dendritic keratitis in man in a double-blind manner with IDU. The success rate for this agent was similar to IDU and was found efficacious in cases not responsive to IDU. Prophylaxis with In-Cn did not prevent recurrences of epithelial herpes, but such recurrences were responsive to IDU or In-Cn.

Acute Disease↗
PubMed1976

Topical epinephrine and cystoid macular edema.

Epinephrine maculopathy occurred in one eye of a patient that spontaneously developed intraretinal cystic maculopathy in the other eye. The clinical and fluorescein angiographic apperance of the two conditions were identical. It is likely that the two conditions have a common organic denominator.

Administration, Topical↗
PubMed1976

Conjunctival eye signs in GM1 type 1 gangliosidosis.

Two cases of GM1 type 1 gangliosidosis demonstrated microvascular abnormalities of the conjunctiva, as well as skin abnormalities in one case. This abnormality was studied by light and electron microscopy of a conjunctival biopsy; cytoplasmic vesicles were noted in the endothelial cells, producing a mechanical narrowing of the lumen. This storage material is similar to that seen in the fibroblasts of skin and of visceral organs in GM1 gangliosidosis, as well as to the material described in the systemic mucopolysaccharidoses. The material probably represents a keratan sulfate-like material. The conjunctiva provides a ready source for biopsy and diagnostic evaluation.

Conjunctiva↗
PubMed1976

Tissue culture studies of contact lenses.

Standard methylmethacrylate hard contact lenses and several available soft (HEMA) contact lenses were studied in tissue culture using secondary rabbit kidney cells. No toxic constituents were found but the cells were readily destroyed by a keratoprosthesis which was found to be toxic in culture. The tissue culture technique should assist in determining which plastics are most suitable for in vivo use and make conclusions concerning mechanical or metabolic effects of lenses more meaningful.

Animals↗
PubMed1975

A model for steroid effects in herpes keratitis.

Dextran-Blue 2000 was used as a marker to determine the effect of steroids on large molecule transfer through the cornea. In superficially scarified corneas topically applied steroids greatly enhanced the transfer of this chromophore through the cornea in the in vivo state, but had little effect in vitro. This implies that the steroid effect is an active process. Since herpes simplex virus is approximately the same molecular weight and configuration as the chromophore used, this study explains one aspect of how steroids may be detrimental when used in the presence of this virus.

Animals↗
PubMed1975

Surgical landmarks in trabecular surgery.

Clinical and histologic studies in 40 eyes of 35 patients with chronic open-angle glaucoma or chronic angle-closure glaucoma operated by various types of "trabeculectomies" were assessed to evaluate whether success was correlated with the surgical approach or with the presence of trabecular tissue in the pathologic specimen. It was clearly demonstrated that it is not necessary to localize or enter Schlemm's canal in order to perform successful trabeculectomies; it is not necessary to operate posterior to the scleral spur; and it is not necessary to excise either Schlemm's canal or trabecular tissue to achieve success. In essence, trabeculectomies primarily function as fistulizing operations carried out under scleral flaps substituting a scleral-conjunctival barrier to aqueous flow rather than the conjunctival barrier alone provided by standard glaucoma operations. This greater obstruction explains the absence of shallow chambers, the reduced incidence of polycystic bleb formation and, perhaps, an avoidance of long-term complications that often result from these two factors.

Glaucoma↗
PubMed1975

Tissue culture methods for testing the toxicity of ocular plastic materials.

A screening method using tissue culture techniques determined inertness of ocular alloplastics. Secondary rabbit kidney cells revealed the presence of toxic constituents by absence of growth or cytopathic changes, or both. The optical portions of the lenses studied were nontoxic, whereas the polyamide loops of one lens were toxic. A keratoprosthesis that had been in situ in a patient for two years was highly toxic in culture. A neutralized agar overlay technique was not sufficiently sensitive to screen anterior chamber implants. The tissue culture technique, in combination with chemical, optical, and animal experimentation, may be helpful in determining which implant systems are most suitable for in vivo use.

Amides↗
PubMed1975

Calculation of the optical power of intraocular lenses.

A rather simple clinical approach has been used to derive formulas necessary to calculate the power of pupillary intracameral prosthetics and these have been applied in 150 eyes. In 136 eyes, the postoperative measurements were within one diopter of preoperative calculations.

Adult↗
PubMed1975

Surgical technique of cyclodialysis lens extraction.

Cyclodialysis lens extraction is a safe, predictable procedure for simultaneous surgery of cataract and glaucoma. A few maneuvers outlined in this paper which differ from the cyclodialysis approach to the aphakic eye significantly reduce the problem of hyphema and corneal damage.

Anterior Chamber↗